Now showing items 1-4 of 4

    • Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein 

      Lindquist, Susan; Jasanoff, Alan Pradip; Ma, Jiyan; Wang, Xinhe; Borkowski, Andrew W.; e.a. (Elsevier, 2009-10)
      We analyzed the relationship between pathogenic protein expression and perturbations to brain anatomy and physiology in a genetic model of prion disease. In this model, the mouse line 1D4, neuropathology is promoted by ...
    • In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast 

      Lee, Taekwan; Zhang, Xiao-an; Dhar, Shanta; Faas, Henryk; Lippard, Stephen J.; e.a. (Elsevier B.V., 2010-06)
      Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular ...
    • In vivo imaging with a cell-permeable porphyrin-based MRI contrast agent 

      Lee, Taekwan; Zhang, Xiao-an; Dhar, Shanta; Faas, Henryk; Lippard, Stephen J.; e.a. (Elsevier, 2010-06)
      Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular ...
    • Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice 

      Faas, Henryk; Watson, Nicki; Borkowski, Andrew W.; Jasanoff, Alan Pradip; King, Oliver D.; e.a. (Elsevier Inc., 2009-08)
      A crucial tenet of the prion hypothesis is that misfolding of the prion protein (PrP) induced by mutations associated with familial prion disease is, in an otherwise normal mammalian brain, sufficient to generate the ...