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Browsing MIT Open Access Articles by Title

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  • Zwaans, Bernadette M.M.; Silberman, Dafne M.; Goren, Alon; Zhong, Lei; Ram, Oren; Truelove, Jessica; Guimaraes, Alexander R.; Toiber, Debra; Cosentino, Claudia; Greenson, Joel K.; MacDonald, Alasdair I.; McGlynn, Liane; Maxwell, Fraser; Edwards, Joanne; Giacosa, Sofia; Guccione, Ernesto; Weissleder, Ralph; Bernstein, Bradley E.; Regev, Aviv; Shiels, Paul G.; Lombard, David B.; Mostoslavsky, Raul; Sebastian, Carlos; Gymrek, Melissa A.; Bernstein, Bradley E. (Elsevier, 2012-12)
    Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a ...
  • Beyaz, Semir; Kim, Ji Hyung; Pinello, Luca; Hu, Yu; Huang, Jialiang; Kerenyi, Marc A; Das, Partha P; Barnitz, R Anthony; Herault, Aurelie; Haining, W Nicholas; Passegue, Emmanuelle; Yuan, Guo-Cheng; Orkin, Stuart H; Winau, Florian; Xifaras, Michael; Dogum, Rizkullah; Yilmaz, Omer (Springer Nature, 2017-02)
    Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. ...
  • Creyghton, Menno P.; Cheng, Albert W.; Welstead, G. Grant; Kooistra, Tristan G.; Carey, Bryce W.; Steine, Eveline J.; Hanna, Jacob; Lodato, Michael Anthony; Frampton, Garrett M.; Sharp, Phillip A.; Boyer, Laurie; Young, Richard A.; Jaenisch, Rudolf (National Academy of Sciences (U.S.), 2010-11)
    Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers ...
  • Yuan, Chih-Chi; Jin, Yi; Chen, Chang Feng; Chapman, Brad A.; Ohsumi, Toshiro K.; Glass, Karen C.; Kutateladze, Tatiana G.; Borowsky, Mark L.; Struhl, Kevin; Oettinger, Marjorie A.; Matthews, Adam G. W. (Elsevier, 2012-01)
    The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) ...
  • Román, Angel-Carlos; Vicente-Page, Julián; Carvajal-González, Jose M; Fernández-Salguero, Pedro M; de Polavieja, Gonzalo G; Carvajal-González, Jose M.; Fernández-Salguero, Pedro M.; de Polavieja, Gonzalo G.; Perez Escudero, Alfonso (Biomed Central Ltd, 2018-04)
    Background Animals can show very different behaviors even in isogenic populations, but the underlying mechanisms to generate this variability remain elusive. We use the zebrafish (Danio rerio) as a model ...
  • Heintzman, Nathaniel D.; Hon, Gary C.; Hawkins, R. David; Kheradpour, Pouya; Stark, Alexander; Harp, Lindsey F.; Ye, Zhen; Lee, Leonard K.; Stuart, Rhona K.; Ching, Christina W.; Ching, Keith A.; Antosiewicz-Bourget, Jessica E.; Liu, Hui; Zhang, Xinmin; Green, Roland D.; Lobanenkov, Victor V.; Stewart, Ron; Thomson, James A.; Crawford, Gregory E.; Kellis, Manolis; Ren, Bing (Nature Publishing Group, 2009-03)
    The human body is composed of diverse cell types with distinct functions. Although it is known that lineage specification depends on cell-specific gene expression, which in turn is driven by promoters, enhancers, insulators ...
  • Monier, Erwan; Schlosser, Adam; Sokolov, Andrei P. (Copernicus GmbH, 2013-05)
    Both historical and idealized climate model experiments are performed with a variety of Earth system models of intermediate complexity (EMICs) as part of a community contribution to the Intergovernmental Panel on Climate ...
  • Manning, David A.C.; Ciceri, Davide; Allanore, Antoine (Elsevier B.V., 2014-10)
    The mining of soluble potassium salts (potash) is essential for manufacturing fertilizers required to ensure continuous production of crops and hence global food security. As of 2014, potash is mined predominantly in the ...
  • Mahlstein, Irina; Gent, Peter R.; Solomon, Susan (American Geophysical Union (AGU), 2013-06)
    In contrast to Arctic sea ice, average Antarctic sea ice area is not retreating but has slowly increased since satellite measurements began in 1979. While most climate models from the Coupled Model Intercomparison Project ...
  • McNerney, James; Doyne Farmer, J.; Trancik, Jessika (Elsevier, 2011-04)
    We study the cost of coal-fired electricity in the United States between 1882 and 2006 by decomposing it in terms of the price of coal, transportation cost, energy density, thermal efficiency, plant construction cost, ...
  • McCants, Anne E. C. (M.I.T. Press, 2009)
  • Cavicchi, Elizabeth (Springer-Verlag, 2008-08)
    Two students, meeting together with a teacher, redid historical experiments. Unlike conventional instruction where science topics and practices often fragment, they experienced interrelatedness among phenomena, participants’ ...
  • Meinshausen, Malte; Vogel, Elisabeth; Nauels, Alexander; Lorbacher, Katja; Meinshausen, Nicolai; Etheridge, David M.; Fraser, Paul J.; Montzka, Stephen A.; Rayner, Peter J.; Trudinger, Cathy M.; Krummel, Paul B.; Beyerle, Urs; Canadell, Josep G.; Daniel, John S.; Enting, Ian G.; Law, Rachel M.; Lunder, Chris R.; Reimann, Stefan; Rubino, Mauro; Velders, Guus J. M.; Vollmer, Martin K.; Wang, Ray H. J.; Weiss, Ray; O'Doherty, Simon; Prinn, Ronald G (Copernicus GmbH, 2017-05)
    Atmospheric greenhouse gas (GHG) concentrations are at unprecedented, record-high levels compared to the last 800 000 years. Those elevated GHG concentrations warm the planet and - partially offset by net cooling effects ...
  • Win, Moe Z.; Dardari, Davide; Molisch, A. F.; Wiesbeck, W.; Zhang, Jinyun (Institute of Electrical and Electronics Engineers, 2009-03)
    This mathematical modeling method for wireless networks is designed to take into account propagation effects and interference from unwanted transmissions.
  • Rigby, Matthew; Muhle, Jens; Miller, Benjamin R.; Prinn, Ronald G.; Krummel, P. B.; Steele, L. P.; Fraser, P. J.; Salameh, P. K.; Harth, C. M.; Weiss, R. F.; Greally, B. R.; O'Doherty, Simon; Simmonds, P. G.; Vollmer, M. K.; Reimann, S.; Kim, J.; Kim, K.-R.; Wang, H. J.; Olivier, Jos G. J.; Dlugokencky, E.; Dutton, G. S.; Hall, B. D.; Elkins, J. W. (European Geosciences Union / Copernicus, 2010-11)
    We present atmospheric sulfur hexafluoride (SF6)[SF subscript 6] mole fractions and emissions estimates from the 1970s to 2008. Measurements were made of archived air samples starting from 1973 in the Northern Hemisphere ...
  • Prinn, Ronald G; DeWitt, Helen Langley (Copernicus GmbH, 2018-06)
    We present the organization, instrumentation, datasets, data interpretation, modeling, and accomplishments of the multinational global atmospheric measurement program AGAGE (Advanced Global Atmospheric Gases Experiment). ...
  • Khrameeva, Ekaterina E.; Gelfand, Mikhail S.; Fudenberg, Geoffrey; Mirny, Leonid A (World Scientific Publishing, 2016-03)
    Three-dimensional (3D) organization of genomes affects critical cellular processes such as transcription, replication, and deoxyribo nucleic acid (DNA) repair. While previous studies have investigated the natural role, the ...
  • Boyden, Edward Stuart (BioMed Central Ltd., 2011-05)
    Understanding how different kinds of neuron in the brain work together to implement sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron result in brain diseases, has long been a ...
  • Hughes, Jennifer; Page, David C (Springer Nature, 2016-05)
    Studies of the Y chromosome over the past few decades have opened a window into the history of our species, through the reconstruction and exploitation of a patrilineal (Y-genealogical) tree based on several hundred ...
  • de Foy, B.; Krotkov, N. A.; Bei, Naifang; Herndon, S. C.; Huey, L. G.; Martinez, A.-P.; Ruiz-Suarez, L. G.; Wood, E. C.; Zavala, Miguel; Molina, Luisa Tan (Copernicus Publications on behalf of the European Geophysical Society, 2009-12)
    Large sulfur dioxide plumes were measured in the Mexico City Metropolitan Area (MCMA) during the MILAGRO field campaign. This paper seeks to identify the sources of these plumes and the meteorological processes that affect ...
Open Access