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Browsing MIT Open Access Articles by Title

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  • Balakrishnan, Hamsa; Pfeil, Diana Michalek (Institute for Operations Research and the Management Sciences (INFORMS), 2011-06)
    Convective weather is responsible for large delays and widespread disruptions in the U.S. National Airspace System, especially during summer. Traffic flow management algorithms require reliable forecasts of route blockage ...
  • Onder, Tamer T.; Jiang, Guozhi; Tao, Kai; Kuperwasser, Charlotte; Weinberg, Robert A.; Lander, Eric S.; Gupta, Piyush (Elsevier, 2009-08)
    Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe ...
  • Umeton, Renato; Stracquadanio, Giovanni; Papini, Alessio; Costanza, Jole; Nicosia, Giuseppe; Lio, Pietro (Springer-Verlag, 2012)
    Understanding and optimizing the CO[subscript 2] fixation process would allow human beings to address better current energy and biotechnology issues. We focused on modeling the C[subscript 3] photosynthetic Carbon metabolism ...
  • Melas, Ioannis N.; Lauffenburger, Douglas A.; Alexopoulos, Leonidas G. (Institute of Electrical and Electronics Engineers (IEEE), 2013-11)
    Hepatocellular Carcinoma (HCC) is one of the leading causes of death worldwide, with only a handful of treatments effective in unresectable HCC. Most of the clinical trials for HCC using new generation interventions ...
  • Shan, Jing; Ross, Nathan T.; Logan, David J.; Thomas, David; Duncan, Stephen A.; North, Trista E.; Goessling, Wolfram; Carpenter, Anne E.; Schwartz, Robert; Bhatia, Sangeeta N. (2013-06)
    Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. ...
  • Sail, Vibhavari; Rizzo, Alessandro A.; Dash, Radha C.; Ozen, Zuleyha; Korzhnev, Dmitry M.; Hadden, M. Kyle; Chatterjee, Nimrat; Walker, Graham C (American Chemical Society (ACS), 2017-07)
    Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic ...
  • Barthelme, Dominik; Sauer, Robert T. (American Association for the Advancement of Science, 2012-07)
    Proteasomes are the major energy-dependent proteolytic machines in the eukaryotic and archaeal domains of life. To execute protein degradation, the 20S core peptidase combines with the AAA+ ring of the 19S regulatory ...
  • Yukita, M.; Ptak, A.; Hornschemeier, A. E.; Wik, D.; Maccarone, T. J.; Pottschmidt, K.; Zezas, A.; Antoniou, V.; Ballhausen, R.; Lehmer, B. D.; Lien, A.; Williams, B.; Boyd, P. T.; Enoto, T.; Kennea, J.; Page, K. L.; Choi, Y.; Baganoff, Frederick K (IOP Publishing, 2017-03)
    We report the identification of a bright hard X-ray source dominating the M31 bulge above 25 keV from a simultaneous NuSTAR–Swift observation. We find that this source is the counterpart to Swift J0042.6+4112, which was ...
  • McFetridge, Kiva; Camejo, Ana; Gold, Daniel A.; Lu, Diana; Julien, Lindsay; Yang, Ninghan; Jensen, Kirk D C; Saeij, Jeroen (Elsevier, 2013-09)
    The rhoptries are key secretory organelles from apicomplexan parasites that contain proteins involved in invasion and modulation of the host cell. Some rhoptry proteins are restricted to the posterior bulb (ROPs) and others ...
  • Regev, Aviv (Nature Publishing Group, 2013-04)
    The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the ...
  • Eyford, Brett A.; Ahmad, Rushdy; Enyaru, John C.; Carr, Steven A.; Pearson, Terry W. (Public Library of Science, 2013-08)
    Control of human African sleeping sickness, caused by subspecies of the protozoan parasite Trypanosoma brucei, is based on preventing transmission by elimination of the tsetse vector and by active diagnostic screening and ...
  • Shen, Yang; Davies, Bryan W.; Vercruysse, Maarten; Koehrer, Caroline; Proulx, Sandra; Ghosal, Anubrata; Rajbhandary, Uttam L; Walker, Graham C (American Society for Microbiology, 2016-11)
    YbeY is part of a core set of RNases in Escherichia coli and other bacteria. This highly conserved endoribonuclease has been implicated in several important processes such as 16S rRNA 3′ end maturation, 70S ribosome quality ...
  • Simcoe, Robert A.; Chen, Shi-Fan S.; Miller, Daniel Robert; Sullivan, P. W. (IOP Publishing, 2015-02)
    Luminous distant quasars are unique probes of the high-redshift intergalactic medium (IGM) and of the growth of massive galaxies and black holes in the early universe. Absorption due to neutral hydrogen in the IGM makes ...
  • Apyan, Aram; Barbieri, R.; Bauer, Gerry P.; Busza, Wit; Cali, Ivan Amos; Chan, M.; Di Matteo, Leonardo; Dutta, V.; Gomez-Ceballos, Guillelmo; Goncharov, Maxim; Gulhan, Doga Can; Klute, Markus; Lai, Yue Shi; Lee, Y.-J.; Levin, A.; Luckey, P. David, Jr.; Ma, Teng; Paus, Christoph M. E.; Ralph, Duncan Kelley; Roland, Christof E.; Roland, Gunther M.; Stephans, George S. F.; Stockli, Fabian; Sumorok, Konstanty C.; Velicanu, Dragos Alexandru; Veverka, Jan; Wyslouch, Boleslaw; Yang, M.; Zanetti, Marco; Zhukova, Victoria (Springer-Verlag, 2014-12)
    In searches for new physics in the energy regime of the LHC, it is becoming increasingly important to distinguish single-jet objects that originate from the merging of the decay products of W bosons produced with high ...
  • Balewski, Jan T.; Betancourt, Michael Joseph; Corliss, Ross; Hays-Wehle, James Prewitt; Leight, William Axel; Milner, Richard G.; Redwine, Robert P; Seele, J.; Steadman, Stephen G.; Surrow, Bernd; van Nieuwenhuizen, G.; Walker, M. (American Physical Society, 2012-02)
    We report transverse momentum (pT≤15  GeV/c) spectra of π[superscript ±], K[superscript ±], p, p̅ , K[subscript S][superscript 0], and ρ[superscript 0] at midrapidity in p+p and Au+Au collisions at √sNN=200  GeV. Perturbative ...
  • Surrow, Bernd; Balewski, Jan T.; Betancourt, Michael Joseph; Hays-Wehle, James Prewitt; Hoffman, A. M.; Jones, Christopher LaDon; Kocoloski, Adam Philip; Leight, William Axel; Milner, Richard G.; Redwine, Robert P.; Sakuma, Tai; Seele, Joseph Patrick; Stephans, George S. F.; van Nieuwenhuizen, Gerrit Jan; Walker, M.; Corliss, Ross Cameron (American Physical Society, 2010-02)
    We present the first measurements of identified hadron production, azimuthal anisotropy, and pion interferometry from Au+Au collisions below the nominal injection energy at the BNL Relativistic Heavy-Ion Collider (RHIC) ...
  • Greenstone, Michael; Hornbeck, Richard; Moretti, Enrico (University of Chicago Press, 2010-06)
    We quantify agglomeration spillovers by comparing changes in total factor productivity (TFP) among incumbent plants in “winning” counties that attracted a large manufacturing plant and “losing” counties that were the new ...
  • Hwang, Gyuweon; Kim, Donghun; Cordero Hernandez, Jose M.; Wilson, Mark William Brennan; Chuang, Chia-Hao Marcus; Grossman, Jeffrey C.; Bawendi, Moungi G (Wiley-Blackwell, 2015-07)
    Chemical oxidation of under-charged Pb atoms reduces the density of trap states by a factor of 40 in films of colloidal PbS quantum dots for devices. These emissive sub-bandgap states are a byproduct of several standard ...
  • H?vel, Philipp; Simini, Filippo; Vanhoof, Maarten; Smoreda, Zbigniew; Barab?si, Albert-L?szl?; Grauwin, Sebastian; Szell, Michael; Sobolevsky, Stanislav; Ratti, Carlo (Nature Publishing Group, 2017-04)
    The idea of a hierarchical spatial organization of society lies at the core of seminal theories in human geography that have strongly influenced our understanding of social organization. Along the same line, the recent ...
  • Miller, Miles Aaron; Feng, Xiao-Jiang; Li, Genyuan; Rabitz, Herschel A. (Public Library of Science, 2012-06)
    This work presents an adapted Random Sampling - High Dimensional Model Representation (RS-HDMR) algorithm for synergistically addressing three key problems in network biology: (1) identifying the structure of biological ...
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