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Browsing MIT Open Access Articles by Title

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  • Minnihan, Ellen Catherine; Seyedsayamdost, Mohammad R.; Uhlin, Ulla; Stubbe, JoAnne (American Chemical Society (ACS), 2011-05)
    Escherichia coli ribonucleotide reductase is an α2β2 complex and catalyzes the conversion of nucleoside 5′-diphosphates (NDPs) to 2′-deoxynucleotides (dNDPs). The reaction is initiated by the transient oxidation of an ...
  • Du, E; Diez-Silva, Monica; Kato, Gregory J.; Dao, Ming; Suresh, Subra (National Academy of Sciences (U.S.), 2015-02)
    We developed a microfluidics-based model to quantify cell-level processes modulating the pathophysiology of sickle cell disease (SCD). This in vitro model enabled quantitative investigations of the kinetics of cell sickling, ...
  • Kabir, Mukul; Van Vliet, Krystyn J (American Chemical Society (ACS), 2015-12)
    Topological Stone–Wales defect in carbon nanotubes plays a central role in plastic deformation, chemical functionalization, and superstructure formation. Here, we systematically investigate the formation kinetics of such ...
  • Patacchini, Leonardo; Hutchinson, Ian H. (American Physical Society, 2009-09)
    The kinetic equation governing a strongly magnetized transverse plasma flow past a convex ion-collecting object is solved numerically for arbitrary ion to electron temperature ratio τ. The approximation of isothermal ions ...
  • Ng, Jonathan; Le, Ari Yitzchak; Daughton, W.; Chen, L.-J. (American Physical Society, 2011-02)
    Strong electron pressure anisotropy has been observed upstream of electron diffusion regions during reconnection in Earth’s magnetotail and kinetic simulations. For collisionless antiparallel reconnection, we find that the ...
  • Kominis, Yannis; Hizanidis, Kyriakos; Ram, Abhay K. (American Physical Society, 2010-06)
    The evolution of a charged particle distribution function under the influence of coherent electromagnetic waves in a plasma is determined from kinetic theory. For coherent waves, the dynamical phase space of particles is ...
  • Drakonakis, Vasileios M.; Seferis, James C.; Wardle, Brian L.; Nam, Jae-Do; Papanicolaou, George C.; Doumanidis, Charalambos C. (Elsevier B.V., 2010-01)
    Kinetic viscoelasticity modeling has been successfully utilized to describe phenomena during cure of thermoset based carbon fiber reinforced matrices. The basic difference from classic viscoelasticity is that the fundamental ...
  • Gascoigne, Karen E; Cheeseman, Iain McPherson (Elsevier, 2010-08)
    Accurate chromosome segregation requires the interaction of chromosomes with the microtubules from the mitotic spindle. This interaction is mediated by the macro-molecular kinetochore complex, which assembles only at the ...
  • Thorpe, Peter H.; Bruno, Joanne H.; Rothstein, Rodney (National Academy of Sciences, 2009-04)
    Asymmetric cell division is of fundamental importance in biology as it allows for the establishment of separate cell lineages during the development of multicellular organisms. Although microbial systems, including the ...
  • Arthanari, Haribabu; Boeszoermenyi, Andras; Dashkevich, Natalia M.; Wilson-Kubalek, Elizabeth M.; Monnier, Nilah; Markus, Michelle A.; Oberer, Monika; Milligan, Ron A.; Bathe, Mark; Wagner, Gerhard; Grishchuk, Ekaterina L.; Schmidt, Jens Christopher; Cheeseman, Iain McPherson (Elsevier, 2012-10)
    To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing ...
  • Thiru, Prathapan; Kern, David Matthew; McKinley, Kara Lavidge; Monda, Julie Kathryn; Rago, Florencia; Su, Kuan-Chung; Tsinman, Tonia; Yarar, Defne; Bell, George W.; Cheeseman, Iain McPherson (American Society for Cell Biology, 2014-05)
    The key player in directing proper chromosome segregation is the macromolecular kinetochore complex, which mediates DNA–microtubule interactions. Previous studies testing individual kinetochore genes documented examples ...
  • Cheeseman, Iain McPherson; Kern, David Matthew (Elsevier B.V., 2012-10)
    Despite the identification of multiple kinetochore proteins, their structure and organization has remained unclear. New work uses electron microscopy to visualize isolated budding yeast kinetochore particles and reveal the ...
  • Kinnan, Cynthia; Townsend, Robert (American Economic Association, 2012-05)
    Kinship networks are beneficial for smoothing consumption and investment, but the channels are not well understood. We study the financing devices used for consumption and investment by Thai households. Households that are ...
  • Merino, Aimee M.; Dugast, Anne-Sophie; Wilson, Craig M.; Goepfert, Paul A.; Alter, Galit; Kaslow, Richard A.; Tang, Jianming (Public Library of Science, 2014-06)
    Background: KIR2DS4 gene variants encode full-length and truncated protein products, with only the former serving as membrane-bound receptors to activate natural killer (NK) cells. We have previously shown that full-length ...
  • Indyk, Piotr; Price, Eric C. (Association for Computing Machinery (ACM), 2011-06)
    We initiate the study of sparse recovery problems under the Earth-Mover Distance (EMD). Specifically, we design a distribution over m x n matrices A such that for any x, given Ax, we can recover a k-sparse approximation ...
  • Chiesa, Alessandro; Micali, Silvio; Zhu, Zeyuan Allen (The Econometric Society, 2015-09)
    We analyze the Vickrey mechanism for auctions of multiple identical goods when the players have both Knightian uncertainty over their own valuations and incomplete preferences. In this model, the Vickrey mechanism is no ...
  • Booker, A. B.; Chen, F.; Sloan, A. M.; Carraway, R. S.; Rennaker, R. L.; LoTurco, J. J.; Kilgard, M. P.; Centanni, Tracy M (Society for Neuroscience, 2016-04)
    Dyslexia is the most common developmental language disorder and is marked by deficits in reading and phonological awareness. One theory of dyslexia suggests that the phonological awareness deficit is due to abnormal ...
  • Kronheimer, P. B.; Mrowka, Tomasz S. (Oxford University Press - London Mathematical Society, 2011-12)
    For each partial flag manifold of SU(N), we define a Floer homology theory for knots in 3-manifolds, using instantons with codimension-2 singularities. In the case of SU(2), the resulting Floer homology group for classical ...
  • Byrne, Alex (Oxford University Press, 2011-04)
    Introduction We often know that we are thinking, and what we are thinking about. Here ‘thinking’ is not supposed to be an umbrella term for cognition in general, but should be taken in roughly the sense of ‘a penny for ...
  • Byrne, Alex (Cambridge University Press, 2011-11)
    As it is silly to ask somebody,‘How do you know you are in pain?’ it is equally foolish to ask, ‘How do you know that you want to go to the movies?’ Vendler, Res Cogitans Knowing that one wants to go to the movies is ...
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