Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Liu, Xu; Ramirez Moreno, Steve; Redondo Pena, Roger L; Tonegawa, Susumu (Cold Spring Harbor Laboratory Press, 2014)
    How memories are formed and stored in the brain remains a fascinating question in neuroscience. Here we discuss the memory engram theory, our recent attempt to identify and manipulate memory engram cells in the brain with ...
  • Covas, P. B.; Effler, A.; Goetz, E.; Meyers, P. M.; Neunzert, A.; Oliver, M.; Pearlstone, B. L.; Roma, V. J.; Schofield, R. M. S.; Adya, V. B.; Astone, P.; Biscoveanu, S.; Callister, T. A.; Christensen, N.; Colla, A.; Coughlin, E.; Coughlin, M. W.; Crowder, S. G.; Dwyer, S. E.; Eggenstein, H.-B.; Hourihane, S.; Kandhasamy, S.; Liu, W.; Lundgren, A. P.; Matas, A.; McCarthy, R.; McIver, J.; Mendell, G.; Ormiston, R.; Palomba, C.; Papa, M. A.; Piccinni, O. J.; Rao, K.; Riles, K.; Sammut, L.; Schlassa, S.; Sigg, D.; Strauss, N.; Tao, D.; Thorne, K. A.; Thrane, E.; Trembath-Reichert, S.; Abbott, B. P.; Abbott, R.; Abbott, T. D.; Adams, C.; Adhikari, R. X.; Ananyeva, A.; Appert, S.; Arai, K.; Aston, S. M.; Austin, C.; Ballmer, S. W.; Barker, D.; Barr, B.; Bartlett, J.; Bartos, I.; Batch, J. C.; Bejger, M.; Bell, A. S.; Betzwieser, J.; Billingsley, G.; Birch, J.; Biwer, C.; Blair, C. D.; Blair, R. M.; Bork, R.; Brooks, A. F.; Cao, H.; Ciani, G.; Clara, F.; Clearwater, P.; Cooper, S. J.; Corban, P.; Countryman, S. T.; Cowart, M. J.; Coyne, D. C.; Cumming, A.; Cunningham, L.; Danzmann, K.; Costa, C. F. Da Silva; Daw, E. J.; DeBra, D.; DeRosa, R. T.; DeSalvo, R.; Dooley, K. L.; Doravari, S.; Driggers, J. C.; Edo, T. B.; Etzel, T.; Factourovich, M.; Fair, H.; Ferreira, E. C.; Fisher, R. P.; Fong, H.; Frey, R.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gateley, B.; Giaime, J. A.; Giardina, K. D.; Goetz, R.; Goncharov, B.; Gray, C.; Grote, H.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Hammond, G.; Hanks, J.; Hanson, J.; Hardwick, T.; Harry, G. M.; Heintze, M. C.; Heptonstall, A. W.; Hough, J.; Inta, R.; Izumi, K.; Jones, R.; Karki, S.; Kasprzack, M.; Kaufer, S.; Kawabe, K.; Kennedy, R.; Kijbunchoo, N.; Kim, W.; King, E. J.; King, P. J.; Kissel, J. S.; Korth, W. Z.; Kuehn, G.; Landry, M.; Lantz, B.; Laxen, M.; Liu, J.; Lockerbie, N. A.; Lormand, M.; Macleod, D. M.; Márka, S.; Márka, Z.; Markosyan, A. S.; Maros, E.; Marsh, P.; Martin, I. W.; Massinger, T. J.; McClelland, D. E.; McCormick, S.; McIntyre, G.; McRae, T.; Merilh, E. L.; Mo, G.; Mogushi, K.; Moraru, D.; Moreno, G.; Mueller, G.; Mukund, N.; Mullavey, A.; Munch, J.; Nelson, T. J. N.; Nguyen, P.; Nuttall, L. K.; Oberling, J.; Oktavia, O.; Oppermann, P.; Oram, Richard J.; O’Reilly, B.; Ottaway, D. J.; Overmier, H.; Palamos, J. R.; Parker, W.; Pele, A.; Penn, S.; Perez, C. J.; Phelps, M.; Pierro, V.; Pinto, I.; Principe, M.; Prokhorov, L. G.; Puncken, O.; Quetschke, V.; Quintero, E. A.; Radkins, H.; Raffai, P.; Ramirez, K. E.; Reid, S.; Reitze, D. H.; Robertson, N. A.; Rollins, J. G.; Romel, C. L.; Romie, J. H.; Ross, M. P.; Rowan, S.; Ryan, K.; Sadecki, T.; Sanchez, E. J.; Sanchez, L. E.; Sandberg, V.; Savage, R. L.; Sellers, D.; Shaddock, D. A.; Shaffer, T. J.; Shapiro, B.; Slagmolen, B. J. J.; Smith, B.; Smith, J. R.; Sorazu, B.; Spencer, A. P.; Staley, A.; Strain, K. A.; Sun, L.; Tanner, D. B.; Tasson, J. D.; Taylor, R.; Thomas, M.; Thomas, P.; Toland, K.; Torrie, C. I.; Traylor, G.; Tuyenbayev, D.; Vajente, G.; Valdes, G.; van Veggel, A. A.; Vecchio, A.; Veitch, P. J.; Venkateswara, K.; Vo, T.; Vorvick, C.; Wade, M.; Walker, M.; Ward, R. L.; Warner, J.; Weaver, B.; Weßels, P.; Willke, B.; Wipf, C. C.; Wofford, J.; Worden, J.; Yamamoto, H.; Yancey, C. C.; Zhang, L.; Zhu, S.; Zweizig, J.; Barsotti, Lisa; Biscans, Sebastien; Evans, Matthew J; Fernandez Galiana, Alvaro-Miguel; Fritschel, Peter K; Gras, Slawomir; Hall, Evan D.; MacInnis, Myron E; Martynov, Denis; Mason, Kenneth R; Matichard, Fabrice; Mavalvala, Nergis; McCuller, Lee P; Miller, John; Mittleman, Richard K; Shoemaker, David H; Tse, Maggie; Weiss, Rainer; Yu, Hang; Yu, Haocun; Zucker, Michael E (American Physical Society, 2018-04)
    Searches are under way in Advanced LIGO and Virgo data for persistent gravitational waves from continuous sources, e.g. rapidly rotating galactic neutron stars, and stochastic sources, e.g. relic gravitational waves from ...
  • Ramirez Moreno, Steve; Tonegawa, Susumu; Liu, Xu (Frontiers Media S.A., 2014)
    With the accumulation of our knowledge about how memories are formed, consolidated, retrieved, and updated, neuroscience is now reaching a point where discrete memories can be identified and manipulated at rapid timescales. ...
  • Sessions, Alex L.; Zhang, Lichun; Welander, Paula V.; Doughty, David; Newman, Dianne K.; Summons, Roger Everett (Elsevier, 2012-12)
    Hopanoids are triterpenoids produced mainly by bacteria, are ubiquitous in the environment, and have many important applications as biological markers. A wide variety of related hopanoid structures exists, many of which ...
  • Chung, Chee Yeun; Khurana, Vikram; Auluck, Pavan K.; Tardiff, Daniel F.; Mazzulli, Joseph R.; Soldner, Frank; Baru, Valeriya; Lou, Yali; Freyzon, Yelena; Cho, Sukhee; Muffat, Julien; Mitalipova, Maisam; Pluth, Michael D.; Jui, Nathan T.; Schule, Birgitt; Lippard, Stephen J.; Tsai, Li-Huei; Krainc, Dimitri; Jaenisch, Rudolf; Lindquist, Susan; Mungenast, Alison; Buchwald, Stephen Leffler (American Association for the Advancement of Science (AAAS), 2013-10)
    The induced pluripotent stem (iPS) cell field holds promise for in vitro disease modeling. However, identifying innate cellular pathologies, particularly for age-related neurodegenerative diseases, has been challenging. ...
  • Yamamoto, Teppei; Imai, Kosuke (Oxford University Press, 2013-01)
    Social scientists are often interested in testing multiple causal mechanisms through which a treatment affects outcomes. A predominant approach has been to use linear structural equation models and examine the statistical ...
  • Klein, Michael G.; Zwart, Peter; Bagby, Sarah C.; Cai, Fei; Chisholm, Sallie (Penny); Heinhorst, Sabine; Cannon, Gordon C.; Kerfeld, Cheryl A. (Elsevier, 2009-09)
    Bacterial microcompartments (BMCs) are polyhedral bodies, composed entirely of proteins, that function as organelles in bacteria; they promote subcellular processes by encapsulating and co-localizing targeted enzymes with ...
  • Strohecker, A M; Joshi, S; Abraham, R T; White, E; Possemato, Richard; Sabatini, David (Nature Publishing Group, 2015-03)
    Deregulation of autophagy has been linked to multiple degenerative diseases and cancer, thus the identification of novel autophagy regulators for potential therapeutic intervention is important. To meet this need, we ...
  • Johnson, Christopher M.; Yuqing, Chen; Lee, Heejin; Ke, Ailong; Weaver, Keith E.; Dunny, Gary M. (National Academy of Sciences (U.S.), 2014-02)
    Anti-Q is a small RNA encoded on pCF10, an antibiotic resistance plasmid of Enterococcus faecalis, which negatively regulates conjugation of the plasmid. In this study we sought to understand how Anti-Q is generated relative ...
  • Cho, Annie; Histon, Jonathan; de Albuquerque Filho, Emilio Alverne Falcao; Hansman, Robert J., Jr. (2011-05)
    In order to identify sectors supporting a minimum differences approach to generic airspace, traffic patterns in 360 high-altitude sectors were examined for common structural features. These structural features are used as ...
  • Welander, Paula V.; Coleman, Maureen L.; Sessions, Alex L.; Summons, Roger Everett; Newman, Dianne K. (National Academy of Sciences, 2010-04)
    The rise of atmospheric oxygen has driven environmental change and biological evolution throughout much of Earth’s history and was enabled by the evolution of oxygenic photosynthesis in the cyanobacteria. Dating this ...
  • Tang, Yun-Chi; Williams, Bret R.; Siegel, Jake J.; Amon, Angelika B. (Elsevier B.V., 2011-02)
    Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer therapies. We have identified the energy stress-inducing ...
  • Torres, Eduardo Martin; Dephoure, Noah; Panneerselvam, Amudha; Tucker, Cheryl M.; Whittaker, Charles A.; Gygi, Steven P.; Dunham, Maitreya J.; Amon, Angelika B. (Elsevier B.V., 2010-10)
    Aneuploidy causes a proliferative disadvantage in all normal cells analyzed to date, yet this condition is associated with a disease characterized by unabated proliferative potential, cancer. The mechanisms that allow ...
  • Wheeler, D. B.; Zoncu, R.; Root, D. E.; Sawyers, C. L.; Sabatini, David (American Association for the Advancement of Science (AAAS), 2015-10)
    In a short hairpin RNA screen for genes that affect AKT phosphorylation, we identified the RAB35 small guanosine triphosphatase (GTPase)—a protein previously implicated in endomembrane trafficking—as a regulator of the ...
  • Broadus, Matthew R.; Chen, Tony W.; Neitzel, Leif R.; Ng, Victoria H.; Jodoin, Jeanne; Lee, Laura A.; Salic, Adrian; Robbins, David J.; Capobianco, Anthony J.; Patton, James G.; Huppert, Stacey S.; Lee, Ethan (Elsevier, 2016-05)
    Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a ...
  • Mani, D. R.; Tsukamoto, Kosuke; Zhang, Songwen; Krieger, Monty; Shi, Jianru; Haagensen, Darrow E.; Otsuka, Fumiyuki; Guan, Jian; Smith, Jonathan D.; Weng, Wei; Liao, Ronglih; Kolodgie, Frank D.; Virmani, Renu (National Academy of Sciences (U.S.), 2013-09)
    Mice with homozygous null mutations in the HDL receptor (scavenger receptor class B, type I, or SR-BI) and apolipoprotein E (apoE) genes [SR-BI/apoE double KO (SR-BI[superscript −/−]/apoE[superscript −/−] or dKO) mice] ...
  • Anderson, Gemma E.; Gaensler, B. M.; Kaplan, David L.; Posselt, Bettina; Slane, Patrick O.; Murray, Stephen S.; Mauerhan, Jon C.; Benjamin, Robert A.; Brogan, Crystal L.; Chakrabarty, Deepto; Drake, Jeremy J.; Drew, Janet E.; Grindlay, Jonathan E.; Hong, Jaesub; Lazio, T. Joseph W.; Lee, Julia C.; Steeghs, Danny T. H.; van Kerkwijk, Marten H. (Institute of Physics Publishing, 2011-01)
    We present X-ray, infrared, optical, and radio observations of four previously unidentified Galactic plane X-ray sources: AX J163252-4746, AX J184738-0156, AX J144701-5919, and AX J144547-5931. Detection of each source ...
  • Johnson, Christopher M.; Grossman, Alan D.; Wright, Laurel (Public Library of Science, 2015-10)
    We identified a functional single strand origin of replication (sso) in the integrative and conjugative element ICEBs1 of Bacillus subtilis. Integrative and conjugative elements (ICEs, also known as conjugative transposons) ...
  • Chen, Nancy; Bellott, Daniel W.; Page, David C.; Clark, Andrew G (BioMed Central Ltd, 2012-05)
    Background: The female-specific W chromosomes and male-specific Y chromosomes have proven difficult to assemble with whole-genome shotgun methods, creating a demand for new approaches to identify sequence contigs specific ...
  • Faherty, Jacqueline K.; Burgasser, Adam J.; Bochanski, John J.; Looper, Dagny L.; West, Andrew A.; van der Bliek, Nicole S. (IOP Publishing, 2011-01)
    We report our discovery of NLTT 20346 as an M5+M6 companion system to the tight binary (or triple) L dwarf 2MASS J0850359+105716. This nearby (~31 pc), widely separated (~7700 AU) quadruple system was identified through a ...
Open Access