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Browsing MIT Open Access Articles by Title

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  • Kwong, Gabriel A.; Carrodeguas, Emmanuel; Mazumdar, Eric V.; Zekavat, Seyedeh M.; Bhatia, Sangeeta N.; Dudani, Jaideep Sunil (National Academy of Sciences (U.S.), 2015-10)
    Advances in nanomedicine are providing sophisticated functions to precisely control the behavior of nanoscale drugs and diagnostics. Strategies that coopt protease activity as molecular triggers are increasingly important ...
  • Brizzolara, S.; Seixas de Medeiros, Joao (Hindawi Publishing Corporation, 2018-01)
    Efficient design of wave energy converters based on floating body motion heavily depends on the capacity of the designer to accurately predict the device’s dynamics, which ultimately leads to the power extraction. We present ...
  • Taylor, Katherine Anne; Shamshery, Pulkit; Wang, Ruoqian; Winter, Amos G. (American Society of Mechanical Engineers, 2015-08)
    This paper presents a mathematical model investigating the physics behind pressure-compensating (PC) drip irrigation emitters. A network of PC emitters, commonly known as drip irrigation, is an efficient way to deliver ...
  • Gardiner, Bruce S.; Zhang, Lihai; Smith, David W.; Pivonka, Peter; Grodzinsky, Alan J. (BioMed Central Ltd, 2011-09)
    Background In many biological and therapeutic contexts, it is highly desirable to target a chemical specifically to a particular tissue where it exerts its biological effect. In this paper, we present a simple, generic, ...
  • Ford Versypt, Ashlee N.; Pack, Daniel W.; Braatz, Richard D. (Elsevier, 2012-10)
    PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is ...
  • Tam, Joshua; Fukumura, Dai; Jain, Rakesh K. (Elsevier B.V., 2009-01)
    We have developed a physiologically based mathematical model, with parameters derived from published experimental data, to simulate the regulatory effects of the leptin pathway on murine energy homeostasis. Model outcomes ...
  • MacMinn, Christopher W.; Juanes, Ruben (Elsevier, 2009-02)
    We present a sharp-interface mathematical model of CO[subscript 2] migration in saline aquifers, which accounts for gravity override, capillary trapping, natural groundwater flow, and the shape of the plume during the ...
  • Etingof, Pavel I; Gerovitch, Vyacheslav; Khovanova, Tanya (American Mathematical Society (AMS), 2015-09)
    Consider a finite set of lines in 3-space. A joint is a point where three of these lines (not lying in the same plane) intersect. If there are L lines, what is the largest possible number of joints? Well, let’s try our ...
  • Shepp, Lawrence A.; Pinto, Pedro C.; Win, Moe Z. (Institute of Electrical and Electronics Engineers, 2009-03)
    n this paper, we introduce a mathematical framework for the characterization of network interference in wireless systems. We consider a network in which the interferers are scattered according to a spatial Poisson process ...
  • Skinner, Brian J (Royal Society, 2016-09)
    Same-sex sexual behaviour is ubiquitous in the animal kingdom, but its adaptive origins remain a prominent puzzle. Here, I suggest the possibility that same-sex sexual behaviour arises as a consequence of the competition ...
  • Friedlander, Eric M.; Holm, Tara S.; Ewing, John; Goldin, Rebecca; Jaco, William H.; Stevens, T. Christine; Thompson, Abigail; Vogan, David A (American Mathematical Society (AMS), 2012-10)
    In the recent report Engage to Excel,1 President Obama’s Council of Advisors on Science and Technology (PCAST) identifies mathematics as a bottleneck in undergraduate Science, Technology, Engineering, and Mathematics (STEM) ...
  • Bouvrie, Jacob Vincent; Rosasco, Lorenzo Andrea; Poggio, Tomaso A.; Smale, S.; Caponnetto, A. (Springer-Verlag, 2009-06)
    We propose a natural image representation, the neural response, motivated by the neuroscience of the visual cortex. The inner product defined by the neural response leads to a similarity measure between functions which we ...
  • Nolivos, Sophie; Upton, Amy L.; Badrinarayanan, Anjana; Zawadzka, Katarzyna; Wiktor, Jakub; Gill, Amber; Arciszewska, Lidia; Nicolas, Emilien; Sherratt, David; Muller, Julius (Nature Publishing Group, 2016-01)
    The Escherichia coli SMC complex, MukBEF, forms clusters of molecules that interact with the decatenase topisomerase IV and which are normally associated with the chromosome replication origin region (ori). Here we demonstrate ...
  • Spivak, David I.; Giesa, Tristan; Jagadeesan, Ravi; Buehler, Markus J (American Chemical Society (ACS), 2015-08)
    Biological materials, such as proteins, often have a hierarchical structure ranging from basic building blocks at the nanoscale (e.g., amino acids) to assembled structures at the macroscale (e.g., fibers). Current software ...
  • Griffith, Linda G.; Rodrigues, Melanie; Nuschke, Austin; Wells, Alan; Yates, Cecelia C. (Mary Ann Liebert, 2013-09)
    Multipotential stromal cells/mesenchymal stem cells (MSCs) are attractive candidates for regenerative therapy due to the ability of these cells to differentiate and positively influence neighboring cells. However, on ...
  • Naba, Alexandra; Clauser, Karl R.; Hoersch, Sebastian; Lui, Hui; Carr, Steven A.; Hynes, Richard O. (American Society for Biochemistry and Molecular Biology, 2011-12)
    The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing both biophysical and biochemical cues that are important regulators of cell proliferation, survival, differentiation, and migration. ...
  • Lippens, Evi; Lee, Kangwon; Mehta, Manav; Koshy, Sandeep T.; Darnell, Max C.; Desai, Rajiv M.; Madl, Christopher M.; Xu, Maria; Zhao, Xuanhe; Chaudhuri, Ovijit; Verbeke, Catia; Kim, Woo Seob; Alim, Karen; Mammoto, Akiko; Ingber, Donald E.; Duda, Georg N.; Mooney, David J.; Huebsch, Nathaniel David (Nature Publishing Group, 2015-09)
    The effectiveness of stem cell therapies has been hampered by cell death and limited control over fate. These problems can be partially circumvented by using macroporous biomaterials that improve the survival of transplanted ...
  • Drakonakis, Vasileios M.; Velisaris, Chris N.; Seferis, James C.; Doumanidis, Charalambos C.; Wardle, Brian L.; Papanicolaou, George C. (John Wiley & Sons, Inc., 2010-05)
    Polymeric composites have gone through a level of maturity beyond the laboratory stage with the development of the Boeing 787, the structure of which contains more than 50% composites. Nonetheless, a basic understanding ...
  • Grogan, Paul Thomas; Siddiqi, Afreen; de Weck, Olivier L. (American Institute of Aeronautics and Astronautics, 2011-08)
    This paper presents matrix-based methods for determining optimal cargo manifests for space exploration. An exploration system is defined as a sequence of in-space and on-surface transports between multiple nodes coupled ...
  • Hendrickx, Julien; Olshevsky, Alexander (Society for Industrial and Applied Mathematics, 2010-10)
    We show that, for any rational p ∈ [1,∞) [p is an element of the set [1, infinity)] except p = 1, 2, unless P = NP, there is no polynomial time algorithm which approximates the matrix p-norm to arbitrary relative precision. ...
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