Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Malliaropoulos, Nikos; Panagiotis, Tsaklis; Jurdan, Mendiguchia; Vasilis, Korakakis; Debasish, Pyne; Peter, Malliaras; Tsapralis, Kyriakos (Dove Medical Press, 2015-06)
    Background: Hamstring injuries are common in many sports, including track and field. Strains occur in different parts of the hamstring muscle but very little is known about whether common hamstring loading exercises ...
  • Witchley, Jessica N.; Mayer, Mirjam; Wagner, Daniel E.; Owen, Jared Huntsman; Reddien, Peter; Witchley, Jessica N.; Wagner, Daniel E. (Elsevier B.V., 2013-08)
    Regeneration requires both potential and instructions for tissue replacement. In planarians, pluripotent stem cells have the potential to produce all new tissue. The identities of the cells that provide regeneration ...
  • Geyer, Hartmut; Herr, Hugh M. (Institute of Electrical and Electronics Engineers, 2010-06)
    While neuroscientists identify increasingly complex neural circuits that control animal and human gait, biomechanists find that locomotion requires little control if principles of legged mechanics are heeded that shape and ...
  • Chalkiadaki, Angeliki; Igarashi, Masaki; Nasamu, Armiyaw Sebastian; Knezevic, Jovana; Guarente, Leonard Pershing (Public Library of Science, 2014-07)
    SIRT1 is a metabolic sensor and regulator in various mammalian tissues and functions to counteract metabolic and age-related diseases. Here we generated and analyzed mice that express SIRT1 at high levels specifically in ...
  • Youngblood, Allison; France, Kevin; Loyd, R. O. Parke; Brown, Alexander; Mason, James P.; Schneider, P. Christian; Tilley, Matt A.; Berta-Thompson, Zachory K.; Buccino, Andrea; Froning, Cynthia S.; Hawley, Suzanne L.; Linsky, Jeffrey; Mauas, Pablo J. D.; Redfield, Seth; Kowalski, Adam; Miguel, Yamila; Rugheimer, Sarah; Segura, Antígona; Roberge, Aki; Vieytes, Mariela; Newton, Elisabeth R (IOP Publishing, 2017-06)
    Characterizing the UV spectral energy distribution (SED) of an exoplanet host star is critically important for assessing its planet's potential habitability, particularly for M dwarfs, as they are prime targets for current ...
  • Overduin, Simon A.; d'Avella, Andrea; Carmena, Jose M.; Bizzi, Emilio (Frontiers Research Foundation, 2014-03)
    Electrical microstimulation studies provide some of the most direct evidence for the neural representation of muscle synergies. These synergies, i.e., coordinated activations of groups of muscles, have been proposed as ...
  • Cheung, Vincent Chi-Kwan; Turolla, Andrea; Agostini, Michela; Silvoni, Stefano; Bennis, Caoimhe; Kasi, Patrick; Paganoni, Sabrina; Bonato, Paolo; Bizzi, Emilio (National Academy of Sciences (U.S.), 2012-08)
    The experimental findings herein reported are aimed at gaining a perspective on the complex neural events that follow lesions of the motor cortical areas. Cortical damage, whether by trauma or stroke, interferes with the ...
  • Cuthbert, Michael Scott; Ariza, Christopher T. (International Society for Music Information Retrieval, 2010-08)
    Music21 is an object-oriented toolkit for analyzing, searching, and transforming music in symbolic (score- based) forms. The modular approach of the project allows musicians and researchers to write simple scripts rapidly ...
  • Gong, Nan-wei; Laibowitz, Mathew Joel; Paradiso, Joseph A. (New Interfaces for Musical Expression, 2009)
    In this project, we have developed a real-time writing instrument for music control. The controller, MusicGrip, can capture the subtle dynamics of the user’s grip while writing or drawing and map this to musical control ...
  • Perry, Ruth (Cambridge University Press, 2015-10)
    Jane Austen played the piano every morning before the rest of the family got up - both for her own pleasure and probably also as an aid to meditation and mental focus. No one has yet fully explored the significance of music ...
  • von Fintel, Kai; Gillies, Anthony S. (Springer Netherlands, 2010-05)
    It is a recurring matra that epistemic must creates a statement that is weaker than the corresponding flat-footed assertion: It must be raining vs. It’s raining. Contrary to classic discussions of the phenomenon such as ...
  • Sheh, Alexander; Lee, Chung-Wei; Masumura, Kenichi; Rickman, Barry H.; Nohmi, Takehiko; Wogan, Gerald N.; Fox, James G.; Schauer, David B. (National Academy of Sciences (U.S.), 2010-08)
    Helicobacter pylori is a human carcinogen, but the mechanisms evoked in carcinogenesis during this chronic inflammatory disease remain incompletely characterized. We determined whether chronic H. pylori infection induced ...
  • Yang, Yue; Huang, Jinghe; Toth, Ildiko; Lichterfeld, Mathias; Yu, Xu G. (Public Library of Science, 2010-12)
    Escape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that ...
  • Helman, Elena; Lander, Eric S. (Nature Publishing Group, 2013-06)
    Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched ...
  • Mishima, Yuji; Paiva, Bruno; Shi, Jiantao; Park, Jihye; Manier, Salomon; Takagi, Satoshi; Massoud, Mira; Perilla-Glen, Adriana; Aljawai, Yosra; Huynh, Daisy; Roccaro, Aldo M.; Sacco, Antonio; Capelletti, Marzia; Detappe, Alexandre; Alignani, Diego; Anderson, Kenneth C.; Munshi, Nikhil C.; Prosper, Felipe; Lohr, Jens G.; Ha, Gavin; Van Allen, Eliezer M.; Michor, Franziska; San Miguel, Jesus F.; Ghobrial, Irene M.; Freeman, Samuel Spenser Sharpe; Adalsteinsson, Viktor A. (Elsevier, 2017-04)
    The development of sensitive and non-invasive “liquid biopsies” presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic ...
  • Politi, Katerina; Song, Xiaoling; Pirun, Mono; Kim-Kiselak, Caroline; Platt, James T.; Lee, Emily; Hodges, Emily; Rosebrock, Adam P.; Bronson, Roderick T.; Socci, Nicholas D.; Hannon, Gregory J.; Varmus, Harold; McFadden, David Glenn; Bhutkar, Arjun; Chen, Frances K.; Santiago, Philip M.; Jacks, Tyler E (National Academy of Sciences (U.S.), 2016-10)
    Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to assess putative driver mutations identified by large-scale sequencing of human cancer genomes. To accurately interpret experiments that ...
  • Lander, Eric S. (American Association for the Advancement of Science, 2011-07)
    Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority ...
  • Fox, Edward J.; Loeb, Lawrence A.; Chawanthayatham, Supawadee; Valentine III, Charles Clinton; Fedeles, Bogdan I; Levine, Stuart S.; Slocum, Stephen L.; Wogan, Gerald N; Croy, Robert G; Essigmann, John M (National Academy of Sciences (U.S.), 2017-03)
    Aflatoxin B₁ (AFB₁) and/or hepatitis B and C viruses are risk factors for human hepatocellular carcinoma (HCC). Available evidence supports the interpretation that formation of AFB₁-DNA adducts in hepatocytes seeds a ...
  • Hobbie, Sven N.; Kalapala, Sarath K.; Bottger, Erik C.; Shcherbakov, Dmitry (Public Library of Science, 2010-04)
    Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine ...
  • Leshchiner, Ignaty; Alexa, Kristen; Kelsey, Peter; Adzhubey, Ivan; Austin-Tse, Christina A.; Cooney, Jeffrey D.; Anderson, Heidi; King, Matthew J.; Stottmann, Rolf W.; Garnaas, Maija K.; Ha, Seungshin; Drummond, Iain A.; Paw, Barry H.; North, Trista E.; Beier, David R.; Goessling, Wolfram; Sunyaev, Shamil R. (Cold Spring Harbor Laboratory Press, 2012-05)
    Genetic mapping of mutations in model systems has facilitated the identification of genes contributing to fundamental biological processes including human diseases. However, this approach has historically required the prior ...
Open Access