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Browsing MIT Open Access Articles by Title

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  • Dargazany, Roozbeh; Khalili, Leila; Itskov, Mikhail; Lin, Jiaqi; Chen, Hsieh; Alexander-Katz, Alfredo (American Physical Society, 2016-10)
    Binary polymer-colloid (PC) composites form the majority of biological load-bearing materials. Due to the abundance of the polymer and particles, and their simple aggregation process, PC clusters are used broadly by nature ...
  • Xie, Xin; Bigdeli Karimi, Majid; Liu, Sanwei; Livermore, Carol; Myanganbayar, Battushig (Multidisciplinary Digital Publishing Institute (MDPI), 2018-07)
    Small-scale, out-of-plane actuators can enable tactile interfaces; however, achieving sufficient actuator force and displacement can require larger actuators. In this work, 2-mm<sup>2</sup> out-of-plane microactuators were ...
  • Cetina, Marko; Grier, Andrew Todd; Vuletic, Vladan (American Physical Society, 2012-12)
    We present, and derive analytic expressions for, a fundamental limit to the sympathetic cooling of ions in radio-frequency traps using cold atoms. The limit arises from the work done by the trap electric field during a ...
  • Chen, Gang; Peterson, G. P. “Bud”; Li, Chen; Wang, Moran (Hindawi Pub. Corp., 2010-03)
    As a result of serious concerns about climate change, high oil prices, and peak oil, energy has become one of the most important issues of our time. Renewable energy and energy-saving technologies are potentially crucial ...
  • Invernale, Michael A.; Tang, Benjamin C.; York, Royce L.; Le, Long; Hou, Yupeng; Anderson, Daniel Griffith (John Wiley & Sons, Inc, 2014-03)
    Here, efforts toward the development of a microneedle-based glucose sensor or “smart patch” for intradermal glucose sensing are described. Metallic microneedle array electrodes, conducting polymers, and glucose oxidase ...
  • Schroeder, Avi; Maa, Ruby C.; Lauwers, Gregory Y.; Polat, Baris E.; Blankschtein, Daniel; Langer, Robert; Traverso, Gio; Schoellhammer, Carl Magnus; Anderson, Daniel Griffith (Wiley Blackwell, 2014-09)
    Both patients and physicians prefer the oral route of drug delivery. The gastrointestinal (GI) tract, though, limits the bioavailability of certain therapeutics because of its protease and bacteria-rich environment as well ...
  • Murueva, A. V.; Shishatskaya, E. I.; Kuzmina, A. M.; Volova, T. G.; Sinskey, Anthony J (Springer US, 2013-05)
    Microparticles made from degradable polyhydroxyalkanoates of different chemical compositions a homopolymer of 3-hydroxybutyric acid, copolymers of 3-hydroxybutyric and 4-hydroxybutyric acids (P3HB/4HB), 3-hydroxybutyric ...
  • Li, Cheri Yingjie; Stevens, Kelly R.; Schwartz, Robert E.; Alejandro, Brian S.; Huang, Joanne H.; Bhatia, Sangeeta N. (Mary Ann Liebert, Inc., 2014-04)
    Drug-induced liver injury is a major cause of drug development failures and postmarket withdrawals. In vitro models that incorporate primary hepatocytes have been shown to be more predictive than model systems which rely ...
  • Engelward, B. P.; Ge, Jing; Chow, Danielle N.; Fessler, Jessica L.; Weingeist, David M.; Wood, David K.; Engelward, Bevin P. (Oxford University Press, 2014-12)
    The single cell gel electrophoresis assay, also known as the comet assay, is a versatile method for measuring many classes of DNA damage, including base damage, abasic sites, single strand breaks and double strand breaks. ...
  • Clark, Amanda M.; Wheeler, Sarah E.; Taylor, Donald P.; Pillai, Venkateswaran C.; Young, Carissa L.; Prantil-Baun, Rachelle; Nguyen, Transon; Stolz, Donna B.; Borenstein, Jeffrey T.; Lauffenburger, Douglas A.; Venkataramanan, Raman; Griffith, Linda G.; Wells, Alan (Royal Society of Medicine, 2014-05)
    Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors ...
  • Cavada-Blanco, Francoise; Zubillaga, Ainhoa L.; Bastidas, Ana Carolina (PeerJ Inc., 2016-03)
    Phytoplankton drives primary productivity in marine pelagic systems. This is also true for the oligotrophic waters in coral reefs, where natural and anthropogenic sources of nutrients can alter pelagic trophic webs. In ...
  • Huskins, Emily L.; Schuster, Brian E.; Cordero, Zachary Copoulos; Schuh, Christopher A (Springer US, 2015-07)
    An experimental design for microcompression on individual powder particles is proposed as a means of testing novel materials without the challenges associated with consolidation to produce bulk specimens. This framework ...
  • Verma, Naveen; Shoeb, Ali H.; Bohorquez, Jose L.; Dawson, Joel L.; Guttag, John V.; Chandrakasan, Anantha P. (Institute of Electrical and Electronics Engineers (IEEE), 2010-04)
    This paper presents a low-power SoC that performs EEG acquisition and feature extraction required for continuous detection of seizure onset in epilepsy patients. The SoC corresponds to one EEG channel, and, depending on ...
  • Verma, Naveen; Shoeb, Ali H.; Chandrakasan, Anantha P.; Guttag, John V. (Institute of Electrical and Electronics Engineers, 2009-08)
    Continuous on-scalp EEG monitoring provides a non-invasive means to detect the onset of seizures in epilepsy patients, but cables from the scalp pose a severe strangulation hazard during convulsions. Since the power of ...
  • Sarpeshkar, Rahul; Fay, Leon; Misra, Vinith (Institute of Electrical and Electronics Engineers, 2009-09)
    We introduce an electrocardiogram (EKG) preamplifier with a power consumption of 2.8 muW, 8.1 muV[subscript rms] input-referred noise, and a common-mode rejection ratio of 90 dB. Compared to previously reported work, this ...
  • Denison, Timothy; Panken, Eric; Carlson, Dave; Shoeb, Ali H. (Institute of Electrical and Electronics Engineers, 2009-11)
    Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
  • Shoeb, Ali H.; Carlson, Dave; Panken, Eric; Denison, Timothy (Institute of Electrical and Electronics Engineers, 2009-11)
    Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
  • Melo, Gabriela; Malcolm, Alison E. (Society of Exploration Geophysicists, 2011-05)
    The conditions under which seismic interferometry (SI) leads to the exact Green's function (GF) are rarely met in practice. As a result, we generally recover only estimates of the true GF. This raises the questions: How ...
  • Bousquet, Marina; Nguyen, Diu; Chen, Cynthia; Shields, Lauren; Lodish, Harvey F. (Ferrata Storti Foundation, 2012-06)
    Background: We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that ...
  • Okuyama, K.; Ikawa, T.; Gentner, B.; Hozumi, K.; Harnprasopwat, R.; Lu, J.; Yamashita, R.; Ha, D.; Toyoshima, T.; Chanda, B.; Kawamata, T.; Yokoyama, K.; Wang, S.; Ando, K.; Lodish, H. F.; Tojo, A.; Kawamoto, H.; Kotani, A.; Lodish, Harvey F (National Academy of Sciences (U.S.), 2013-08)
    Lineage specification is thought to be largely regulated at the level of transcription, where lineage-specific transcription factors drive specific cell fates. MicroRNAs (miR), vital to many cell functions, act ...
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