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Browsing MIT Open Access Articles by Title

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  • Batista, Michael A.; Cox, Karen A.; Ortiz, Christine; Grodzinsky, Alan J.; Han, Lin; Tavakoli Nia, Hadi; Onnerfjord, Patrik; Heinegard, Dick (Elsevier, 2014-06)
    Chondroadherin (CHAD), a class IV small leucine rich proteoglycan/protein (SLRP), was hypothesized to play important roles in regulating chondrocyte signaling and cartilage homeostasis. However, its roles in cartilage ...
  • Sample, Caitlin S.; Xu, Alan K.; Swartz, Sharon M.; Gibson, Lorna (Elsevier, 2015-02)
    Many insect wings change shape dynamically during the wingbeat cycle, and these deformations have the potential to confer energetic and aerodynamic benefits during flight. Due to the lack of musculature within the wing ...
  • Srisungsitthisunti, Pornsak; Tansarawiput, Chookiat; Zhang, Huaichen; Qi, Minghao; Xu, Xianfan; Moon, Euclid Eberle (SPIE, 2010-08)
    We describe a method of detecting nanometer-level gap and tip/tilt alignment between a focusing zone plate mask and a silicon substrate using interferometric-spatial-phase-imaging (ISPI). The zone plate mask is used to ...
  • del Alamo, Jesus A. (Institute of Electrical and Electronics Engineers (IEEE), 2013-09)
    Integrated circuits based on InGaAs Field Effect Transistors are currently in wide use in the RF front-ends of smart phones and other mobile platforms, wireless LANs, high data rate fiber-optic links and many defense and ...
  • Wu, Jonathan; Mari-Buye, Nuria; Fernandez Muinos, Teresa; Borros, Salvador; Favia, Pietro; Semino, Carlos Eduardo (BioMed Central Ltd, 2010-12)
    Background: Isolated hepatocytes removed from their microenvironment soon lose their hepatospecific functions when cultured. Normally hepatocytes are commonly maintained under limited culture medium supply as well as ...
  • Graves, W. S.; Nanni, Emilio Alessandro; Moncton, David E (American Physical Society, 2018-01)
    We present a new method for generation of relativistic electron beams with current modulation on the nanometer scale and below. The current modulation is produced by diffracting relativistic electrons in single crystal Si, ...
  • Lo, Justin H.; von Maltzahn, Geoffrey; Douglass, Jacqueline; Park, Ji-Ho; Sailor, Michael J.; Ruoslahti, Erkki; Bhatia, Sangeeta N. (Royal Society of Chemistry, 2013-06)
    The success of nanoparticle-based cancer therapies ultimately depends on their ability to selectively and efficiently accumulate in regions of disease. Outfitting nanoparticles to actively target tumor-specific markers has ...
  • Zhang, Yuan; Li, Na; Suh, Heikyung; Irvine, Darrell J (Nature Publishing Group, 2018-01)
    Immunostimulatory agents such as agonistic anti-CD137 and interleukin (IL)-2 generate effective anti-tumor immunity but also elicit serious toxicities, hampering their clinical application. Here we show that combination ...
  • McCully, Mark; V. Baptista, Pedro; Mullin, Margaret; Dalby, Matthew J.; Berry, Catherine C.; Osorio De Castro Conde, Joao (Public Library of Science, 2018-02)
    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
  • Chowdary, Praveen D.; Che, Daphne L.; Kaplan, Luke; Chen, Ou; Pu, Kanyi; Cui, Bianxiao; Bawendi, Moungi G. (Elsevier, 2015-12)
    Dynein-dependent transport of organelles from the axon terminals to the cell bodies is essential to the survival and function of neurons. However, quantitative knowledge of dyneins on axonal organelles and their collective ...
  • Morton, Stephen Winford; Lee, Michael J.; Deng, Zhou J.; Dreaden, Erik Christopher; Siouve, Elise; Shopsowitz, Kevin; Shah, Nisarg J.; Yaffe, Michael B.; Hammond, Paula T. (American Association for the Advancement of Science (AAAS), 2014-05)
    Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within a specific period to subsequent exposure to the DNA-damaging ...
  • Lauffer, Sam; Wei, Wei; Matulonis, Ursula; Pepin, David; Birrer, Michael J.; Qi, Ruogu; Wang, Yongheng; Bruno, Peter Michael; Xiao, Haihua; Yu, Yingjie; Li, Ting; Chen, Qixian; Kang, Xiang; Song, Haiqin; Yang, Xi; Huang, Xing; Detappe, Alexandre; Hemann, Michael; Ghoroghchian, Paiman Peter (Nature Publishing Group, 2017-12)
    Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that ...
  • Kulak, Nora; Pridgen, Eric M.; Farokhzad, Omid C.; Langer, Robert; Lippard, Stephen J.; Johnstone, Timothy (American Chemical Society (ACS), 2013-05)
    Nanoparticle (NP) therapeutics have the potential to significantly alter the in vivo biological properties of the pharmaceutically active agents that they carry. Here we describe the development of a polymeric NP, termed ...
  • Bogorad, Roman L.; Yin, Hao; Zeigerer, Anja; Nonaka, Hidenori; Ruda, Vera M.; Zerial, Marino; Koteliansky, Victor; Anderson, Daniel Griffith (Nature Publishing Group, 2014-05)
    Integrins play an important role during development, regulating cell differentiation, proliferation and survival. Here we show that knockdown of integrin subunits slows down the progression of hepatocellular carcinoma ...
  • Goldberg, Michael Solomon; Xing, Deyin; Ren, Yin; Orsulic, Sandra; Bhatia, Sangeeta N.; Sharp, Phillip A. (National Academy of Sciences (U.S.), 2011-01)
    Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP1) with small molecules has been shown to be an effective treatment for ovarian cancer with BRCA mutations. Here, we report the in vivo administration ...
  • Mashelkar, Raghunath Anant; Chimote, Geetanjali; Soni, Shivani; Harfouche, Rania; Basu, Kaushik; Sengupta, Shiladitya (United States National Academy of Sciences, 2009-03)
    The MAPK signal transduction cascade is dysregulated in a majority of human tumors. Here we report that a nanoparticle-mediated targeting of this pathway can optimize cancer chemotherapy. We engineered nanoparticles from ...
  • Dvir, Tal; Bauer, Michael; Schroeder, Avi; Tsui, Jonathan H.; Anderson, Daniel G.; Liao, Ronglih; Kohane, Daniel S.; Langer, Robert (American Chemical Society (ACS), 2011-09)
    We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...
  • Liu, Wenhao; Chauhan, Vikash P.; Lee, Jungmin; Wong, Cliff; Greytak, Andrew B.; Insin, Numpon; Nocera, Daniel G.; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G.; Popovic, Zoran (Wiley Blackwell, 2010-09)
    A nanoparticle toolset was created within the size limits of 10–150 nm for probing size-dependent nanoparticle distribution in solid tumors. By using multiphoton intravital microscopy, the particles were tracked both ...
  • von Maltzahn, Geoffrey; Park, Ji-Ho; Lin, Kevin Yu-Ming; Singh, Neetu; Schwöppe, Christian; Mesters, Rolf; Berdel, Wolfgang E.; Ruoslahti, Erkki; Sailor, Michael J.; Bhatia, Sangeeta N. (Nature Publishing Group, 2011-06)
    Nanomedicines have enormous potential to improve the precision of cancer therapy, yet our ability to efficiently home these materials to regions of disease in vivo remains very limited. Inspired by the ability of communication ...
  • Kwong, Gabriel A.; Wood, David K.; Bhatia, Sangeeta N.; Lin, Kevin Yu-Ming; Warren, Andrew David (American Chemical Society (ACS), 2013-09)
    Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with numerous diseases such ...
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