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Browsing MIT Open Access Articles by Title

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  • Boyden, Edward Stuart (Optical Society, 2013)
    Optogenetic tools are genetically-encoded reagents that, when targeted to specific brain cells, enable their activity to be controlled by light. These tools are having broad impact on science, and may serve clinical roles ...
  • Liu, Xu; Ramirez, Steve; Pang, Petti; Puryear, Corey; Govindarajan, Arvind; Deisseroth, Karl; Tonegawa, Susumu (Nature Publishing Group, 2012-03)
    A specific memory is thought to be encoded by a sparse population of neurons. These neurons can be tagged during learning for subsequent identification3 and manipulation. Moreover, their ablation or inactivation results ...
  • Burguiere, Eric; Monteiro, Patricia; Feng, Guoping; Graybiel, Ann M. (American Association for the Advancement of Science (AAAS), 2013-06)
    Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric disorders, including those characterized by the presence of repetitive behaviors. We developed an optogenetic approach to block repetitive, ...
  • Darrow, Keith N.; Slama, Michaël C.C.; Kozin, Elliott D.; Owoc, Maryanna; Hancock, Kenneth; Kempfle, Judith; Edge, Albert; Lacour, Stephanie; Polley, Daniel; Brown, M. Christian; Lee, Daniel J.; Boyden, Edward (Elsevier, 2014-12)
    Optogenetics has become an important research tool and is being considered as the basis for several neural prostheses. However, few studies have applied optogenetics to the auditory brainstem. This study explored whether ...
  • Berglund, K.; Wen, L.; Dunbar, R. L.; Feng, G.; Augustine, G. J. (Society for Neuroscience, 2016-03)
    Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABA A receptors substantially reduced chloride concentration in granule ...
  • Woolf, David; Hui, Pui-Chuen; Iwase, Eiji; Khan, Mughees; Rodriguez, Alejandro W.; Deotare, Parag; Bulu, Irfan; Johnson, Steven G.; Capasso, Federico; Loncar, Marko (Optical Society of America, 2013-03)
    We present here an optomechanical system fabricated with novel stress management techniques that allow us to suspend an ultrathin defect-free silicon photonic-crystal membrane above a Silicon-on-Insulator (SOI) substrate ...
  • Schleier-Smith, Monika Helene; Leroux, Ian Daniel; Zhang, Hao; Van Camp, Mackenzie Anne; Vuletic, Vladan (American Physical Society (APS), 2011-09)
    We demonstrate cavity sideband cooling of a single collective motional mode of an atomic ensemble down to a mean phonon occupation number ⟨n⟩min⁡=2.0[subscript -0.3][superscript +0.9]. Both ⟨n⟩[subscript min]⁡ and the ...
  • Popovic, Milos; Rakich, Peter T. (Society of Photo-Optical Instrumentation Engineers, 2009-02)
    We describe a proposed new class of optonanomechanical integrated photonic devices that can have self-adaptive behavior and self-adaptive optical frequency response, through the use of optical forces to manipulate their ...
  • Albrecht, Simon H.; Winn, Joshua N.; Van Eylen, Vincent (IOP Publishing, 2016-06)
    The rate of tidal circularization is predicted to be faster for relatively cool stars with convective outer layers, compared to hotter stars with radiative outer layers. Observing this effect is challenging because it ...
  • Weinberg, Nevin N.; Essick, Reed Clasey (IOP Publishing, 2015-12)
    We study the orbital evolution of hot Jupiters due to the excitation and damping of tidally driven g-modes within solar-type host stars. Linearly resonant g-modes (the dynamical tide) are driven to such large amplitudes ...
  • Winn, Joshua Nathan; Howard, Andrew W.; Johnson, John Asher; Marcy, Geoffrey W.; Isaacson, Howard; Shporer, Avi; Bakos, Gaspar A.; Hartman, Joel D.; Holman, Matthew J.; Albrecht, Simon H.; Crepp, Justin R.; Morton, Timothy D. (IOP Publishing, 2011-02)
    We present observations of the Rossiter-McLaughlin effect for two exoplanetary systems, revealing the orientations of their orbits relative to the rotation axes of their parent stars. HAT-P-4b is prograde, with a sky-projected ...
  • Knutson, Heather A.; Showman, Adam P.; Cowan, Nicolas B.; Laughlin, Gregory; Burrows, Adam; Deming, Drake; Crepp, Justin R.; Mighell, Kenneth J.; Agol, Eric; Bakos, Gaspar A.; Charbonneau, David; Desert, Jean-Michel; Fischer, Debra A.; Fortney, Jonathan J.; Hartman, Joel D.; Hinkley, Sasha; Howard, Andrew W.; Johnson, John Asher; Kao, Melodie M.; Langton, Jonathan; Marcy, Geoffrey W.; Lewis, Nicole (IOP Publishing, 2013-03)
    We present the first secondary eclipse and phase curve observations for the highly eccentric hot Jupiter HAT-P-2b in the 3.6, 4.5, 5.8, and 8.0 μm bands of the Spitzer Space Telescope. The 3.6 and 4.5 μm data sets span an ...
  • Oza, Anand U.; Harris, Daniel M.; Moláček, Jan; Siefert, Emmanuel; Bush, John W. M. (American Physical Society (APS), 2017-05)
    A decade ago, Couder and Fort [Phys. Rev. Lett. 97, 154101 (2006)]PRLTAO0031-900710.1103/PhysRevLett.97.154101 discovered that a millimetric droplet sustained on the surface of a vibrating fluid bath may self-propel through ...
  • Lee, Jihye; Wu, Chun-Fang (Society for Neuroscience, 2010-09)
    Synapse formation is tightly associated with neuronal excitability. We found striking synaptic overgrowth caused by Drosophila K+-channel mutations of the seizure and slowpoke genes, encoding Erg and Ca2+-activated ...
  • Ulm, F.-J.; Bauchy, Mathieu; Abdolhosseini Qomi, Mohammad Javad; Pellenq, Roland Jm (American Institute of Physics (AIP), 2014-06)
    Despite advances in the characterization and modeling of cement hydrates, the atomic order in Calcium–Silicate–Hydrate (C–S–H), the binding phase of cement, remains an open question. Indeed, in contrast to the former ...
  • Jamieson, Kelsey S.; Hagerman, Samantha R.; Holler, Eggehard; Ljubimova, Julia Y.; Hammond, Paula T.; Hsu, Bryan Boen (Wiley Blackwell, 2014-06)
    Multidrug regimens can sometimes treat recalcitrant diseases when single-drug therapies fail. Recapitulating complex multidrug administration from controlled release films for localized delivery remains challenging because ...
  • Smits, Wiep Klaas; Goranov, Alexi I.; Grossman, Alan D. (Wiley Blackwell (Blackwell Publishing), 2009-12)
    The essential proteins DnaB, DnaD and DnaI of Bacillus subtilis are required for initiation, but not elongation, of DNA replication, and for replication restart at stalled forks. The interactions and functions of these ...
  • Chen, Jing; Micali, Silvio (The Econometric Society, 2013-01)
    Shimoji and Watson (1998) prove that a strategy of an extensive game is rationalizable in the sense of Pearce if and only if it survives the maximal elimination of conditionally dominated strategies. Briefly, this process ...
  • Shapiro, B. Jesse; Polz, Martin F. (Elsevier, 2014-05)
    We propose that microbial diversity must be viewed in light of gene flow and selection, which define units of genetic similarity, and of phenotype and ecological function, respectively. We discuss to what extent ecological ...
  • Croson, Rachel; Donohue, Karen; Katok, Elena; Sterman, John (Wiley Blackwell, 2013-09)
    The bullwhip effect describes the tendency for the variance of orders in supply chains to increase as one moves upstream from consumer demand. We report on a set of laboratory experiments with a serial supply chain that ...
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