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Browsing MIT Open Access Articles by Title

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  • Leman, Steven W.; McCarthy, Kevin Ahmad; Figueroa-Feliciano, Enectali; Cabrera, B.; Pyle, M.; Resch, R.; Sadoulet, B.; Sundqvist, K. M.; Brink, P. L.; do Couto e Silva, Eduardo; Mirabolfathi, N.; Serfass, B.; Tomada, A. (IOP Publishing, 2011-02)
    We present results on quasidi usion studies in large, 3 inch diameter, 1 inch thick [100] high purity germanium crystals, cooled to 50 mK in the vacuum of a dilution refrigerator, and exposed with 59.5 keV gamma-rays ...
  • Araujo, Paulo Antonio Trinidade; Mafra, Daniela Lopes; Sato, K.; Saito, R.; Kong, Jing; Dresselhaus, Mildred (American Physical Society, 2012-07)
    Phonon self-energy corrections have mostly been studied theoretically and experimentally for phonon modes with zone-center (q=0) wave vectors. Here, gate-modulated Raman scattering is used to study phonons of a single layer ...
  • Raghunathan, Rajamani; Greaney, P. Alex; Grossman, Jeffrey C. (American Institute of Physics (AIP), 2011-06)
    Thermostat algorithms in a molecular dynamics simulation maintain an average temperature of a system by regulating the atomic velocities rather than the internal degrees of freedom. Herein, we present a “phonostat” algorithm ...
  • Brenner, Howard (American Physical Society, 2011-12)
    This paper presents a unified theory of phoretic phenomena in single-component fluids. Simple formulas are given for the phoretic velocities of small inert force-free non-Brownian particles migrating through otherwise ...
  • Sinisi, Riccardo; Sun, Jianwei; Fu, Gregory C. (National Academy of Sciences (U.S.), 2010-11)
    Because carbonyl groups are ubiquitous in organic chemistry, the ability to synthesize functionalized carbonyl compounds, particularly enantioselectively, is an important objective. We have developed a straightforward and ...
  • Lee, Sarah Yunmi; Fujiwara, Yuji; Nishiguchi, Atsuko; Kalek, Marcin; Fu, Gregory C. (American Chemical Society (ACS), 2015-03)
    Substantial progress has been described in the development of asymmetric variants of the phosphine-catalyzed intermolecular [3+2] annulation of allenes with alkenes; however, there have not been corresponding advances for ...
  • Sun, Jianwei; Fu, Gregory C. (American Chemical Society, 2010-03)
    A method for catalytic asymmetric γ sulfenylation of carbonyl compounds has been developed. In the presence of an appropriate catalyst, thiols not only add to the γ position of allenoates, overcoming their propensity to ...
  • Courtemanche, Marc Andre; Transue, Wesley; Cummins, Christopher C (American Chemical Society (ACS), 2016-11)
  • Locasale, Jason W.; Grassian, Alexandra R.; Melman, Tamar; Lyssiotis, Costas A.; Mattaini, Katherine Ruth; Bass, Adam J.; Heffron, Gregory J.; Metallo, Christian M.; Muranen, Taru; Sharfi, Hadar; Sasaki, Atsuo T.; Anastasiou, Dimitrios; Mullarky, Edouard; Vokes, Natalie I.; Sasaki, Mika; Beroukhim, Rameen; Stephanopoulos, Gregory; Ligon, Azra H.; Meyerson, Matthew L.; Richardson, Andrea L.; Chin, Lynda; Wagner, Gerhard; Asara, John M.; Brugge, Joan S.; Cantley, Lewis C.; Vander Heiden, Matthew G. (Nature Publishing Group, 2011-07)
    Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2]. Using a metabolomics approach with ...
  • Taniguchi, Cullen M.; Winnay, Jonathon; Kondo, Tatsuya; Bronson, Roderick T.; Guimaraes, Alexander R.; Aleman, Jose O.; Luo, Ji; Stephanopoulos, Gregory; Weissleder, Ralph; Cantley, Lewis C.; Kahn, C. Ronald (American Association for Cancer Research, 2010-06)
    Phosphoinositide 3-kinase (PI3K) plays a critical role in tumorigenesis, and the PI3K p85 regulatory subunit exerts both positive and negative effects on signaling. Expression of Pik3r1, the gene encoding p85, is decreased ...
  • Pong, Terrence; Scherrer-Crosbie, Marielle; Atochin, Dmitriy N.; Bloch, Kenneth D.; Huang, Paul L. (Public Library of Science, 2014-01)
    Objective: Myocardial infarction resulting from ischemia-reperfusion injury can be reduced by cardiac postconditioning, in which blood flow is restored intermittently prior to full reperfusion. Although key molecular ...
  • You, Youngmin; Lee, Sumin; Kim, Tae Hee; Ohkubo, Kei; Chae, Weon-Sik; Fukuzumi, Shunichi; Jhon, Gil-Ja; Nam, Wonwoo; Lippard, Stephen J. (American Chemical Society (ACS), 2011-10)
    A new phosphorescent zinc sensor (ZIrF) was constructed, based on an Ir(III) complex bearing two 2-(2,4-difluorophenyl)pyridine (dfppy) cyclometalating ligands and a neutral 1,10-phenanthroline (phen) ligand. A zinc-specific ...
  • You, Youngmin; Han, Yejee; Lee, Yong-Min; Park, Soo Young; Nam, Wonwoo; Lippard, Stephen J. (American Chemical Society (ACS), 2011-07)
    A phosphorescent sensor based on a multichromophoric iridium(III) complex was synthesized and characterized. The construct exhibits concomitant changes in its phosphorescence intensity ratio and phosphorescence lifetime ...
  • Cummins, Christopher C. (MIT Press, 2014-09)
    The chemistry of the element phosphorus offers a window into the diverse field of inorganic chemistry. Fundamental investigations into some simple molecules containing phosphorus reveal much about the ramifications of this ...
  • Li, Feng; Cho, Richard W.; Buhl, Lauren Kaye; Volfson, Dina; Tran, Adrienne L.; Akbergenova, Yulia; Littleton, J. Troy (Elsevier/Cell Press, 2015-11)
    Synaptic plasticity is a fundamental feature of the nervous system that allows adaptation to changing behavioral environments. Most studies of synaptic plasticity have examined the regulated trafficking of postsynaptic ...
  • Lu, Gang; Zhang, Qing; Huang, Ying; Song, Jiaxi; Lim, Elgene; Liu, Wenbin; Bronson, Roderick T.; Bowden, Michaela; Brock, Jane; Krop, Ian E.; Dillon, Deborah A.; Gygi, Steven P.; Mills, Gordon B.; Richardson, Andrea L.; Signoretti, Sabina; Kaelin, William G.; Tomaino, Ross; Yaffe, Michael B; Ehrenberger, Tobias (Elsevier, 2014-08)
    Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at ...
  • Tao, Jifang; Hu, Keping; Chang, Qiang; Wu, Hao; Sherman, Nicholas E.; Martinowich, Keri; Klose, Robert J.; Schanen, Carolyn; Jaenisch, Rudolf; Wang, Weidong; Sun, Yi Eve (National Academy of Sciences, 2009-02)
    Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although ...
  • Kim, Dennis H.; Matsumoto, Kunihiro; Hisamoto, Naoki; Shivers, Robert P.; Pagano, Daniel Joseph; Kooistra, Tristan G.; Richardson, Claire Elissa; Reddy, Kirthi C.; Whitney, Janelle Kristen; Kamanzi, Odile (Public Library of Science, 2010-04)
    Innate immunity in Caenorhabditis elegans requires a conserved PMK-1 p38 mitogen-activated protein kinase (MAPK) pathway that regulates the basal and pathogen-induced expression of immune effectors. The mechanisms by which ...
  • Nelson, Christopher D.; Kim, Myung Jong; Hsin, Honor; Chen, Yelin; Sheng, Morgan (Society for Neuroscience, 2013-07)
    Activity of glycogen synthase kinase-3β (GSK-3β) is required for long-term depression (LTD) via molecular mechanisms that are incompletely understood. Here, we report that PSD-95, a major scaffold protein of the postsynaptic ...
  • Johnson, Hannah; Lescarbeau, Rebecca S.; Gutierrez, Jesus A.; White, Forest M. (American Chemical Society (ACS), 2013-02)
    Growth factor signaling is deregulated in cancer and often leads to invasion, yet receptor tyrosine kinase signaling pathways driving invasion under different growth factor conditions are not well understood. To identify ...
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