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Browsing MIT Open Access Articles by Title

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  • Mason, Frank M; Xie, Shicong; Vasquez, Claudia G; Tworoger, Michael B; Martin, Adam C (Rockefeller University Press, The, 2016-08)
    During morphogenesis, contraction of the actomyosin cytoskeleton within individual cells drives cell shape changes that fold tissues. Coordination of cytoskeletal contractility is mediated by regulating RhoA GTPase activity. ...
  • Shen, Xiaoqiang; Buchwald, Stephen Leffler (Wiley Blackwell, 2009-12)
    One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). ...
  • Kondoh, Azusa; Jamison, Timothy F. (Royal Society of Chemistry, 2010-01)
    A rhodium-catalyzed dehydrogenative borylation of cyclic alkenes is described. This reaction provides direct access to cyclic 1-alkenylboronic acid pinacol esters, useful intermediates in organic synthesis. Suzuki–Miyaura ...
  • Armbrust, Kurt; Beaver, Matthew G.; Jamison, Timothy F (American Chemical Society (ACS), 2015-06)
    [Rh(CO)₂Cl]₂ is as an effective catalyst for endo-selective cyclizations and cascades of epoxy-(E)-enoate alcohols, thus enabling the synthesis of oxepanes and oxepane-containing polyethers from di- and trisubstituted ...
  • MacEachran, Daniel P.; Sinskey, Anthony J. (BioMed Central Ltd, 2013-11)
    Background: The Gram-positive actinomycete Rhodococcus opacus is widely studied for its innate ability to store large amounts of carbon in the form of triacylglycerol (TAG). Several groups have demonstrated that R. opacus ...
  • Niedelman, Wendy Leah; Gold, Daniel; Rosowski, Emily Elizabeth; Sprokholt, Joris Kasper; Lim, Daniel Cham-Chin; Arenas, Ailan Farid; Melo, Mariane Bandeira; Spooner, Eric; Yaffe, Michael B.; Saeij, Jeroen (Public Library of Science, 2012-06)
    The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the immune response allowing it to establish a chronic infection. Crosses between the types I, II and III ...
  • Jackson, Noel B. (Duke University Press, 2009-06)
    The poetics of Erasmus Darwin's Botanic Garden, its status as an aesthetic as opposed to a purely scientific artifact, and the formal logic of the genre its author popularized have received scant historical attention. ...
  • London, Justin; Polak, Rainer; Jacoby, Kinor (Springer US, 2016-07)
    Studies of musical corpora have given empirical grounding to the various features that characterize particular musical styles and genres. Palmer & Krumhansl (1990) found that in Western classical music the likeliest places ...
  • Fischer, Michael M. J. (Society for Cultural Anthropology, 2010-07)
    This essay investigates three methods for reading topical events, in this case events in Iran in 2009. Timing, as in music, is part of the trick of Iranian (as also other) politics, In Part I, breaking news is read in terms ...
  • Maris, Eric; Womelsdorf, Thilo; Desimone, Robert; Fries, Pascal (Elsevier, 2013-02)
    Groups of neurons tend to synchronize in distinct frequency bands. Within a given frequency band, synchronization is defined as the consistency of phase relations between site pairs, over time. This synchronization has ...
  • Danish, Husain Haiderali; Aronov, Dmitriy; Fee, Michale Sean (Public Library of Science, 2017-06)
    Birdsong is a complex behavior that exhibits hierarchical organization. While the representation of singing behavior and its hierarchical organization has been studied in some detail in avian cortical premotor circuits, ...
  • Lafuente, Esther M.; Krause, Matthias; Carman, Christopher V.; Freeman, Gordon J.; Berezovskaya, Alla; Constantine, Erica; Springer, Timothy A.; Boussiotis, Vassiliki A.; Gertler, Frank; van Puijenbroek, Andre A.F.L. (Elsevier, 2004-10)
    The small GTPase Rap1 induces integrin-mediated adhesion and changes in the actin cytoskeleton. The mechanisms that mediate these effects of Rap1 are poorly understood. We have identified RIAM as a Rap1-GTP-interacting ...
  • Green, Alexander A.; Kim, Jongmin; Ma, Duo; Silver, Pamela A.; Yin, Peng; Collins, James J. (Association for Computing Machinery (ACM), 2016-09)
    Synthetic biology aims to create functional devices, systems, and organisms with novel and useful functions taking advantage of engineering principles applied to biology. Despite great progress ...
  • Gomez, James E; Kaufmann-Malaga, Benjamin B; Wivagg, Carl N; Kim, Peter B; Silvis, Melanie R; Renedo, Nikolai; Ioerger, Thomas R; Ahmad, Rushdy; Livny, Jonathan; Fishbein, Skye; Hung, Deborah T; Carr, Steven A (eLife Sciences Publications, Ltd., 2017-02)
    Antibiotic resistance arising via chromosomal mutations is typically specific to a particular antibiotic or class of antibiotics. We have identified mutations in genes encoding ribosomal components in Mycobacterium smegmatis ...
  • Gangaramani, Paritosh; Thompson, Mary Katherine; Rojas, Maria F.; Gilbert, Wendy (eLife Sciences Publications, Ltd., 2016-04)
    Translation is a core cellular process carried out by a highly conserved macromolecular machine, the ribosome. There has been remarkable evolutionary adaptation of this machine through the addition of eukaryote-specific ...
  • Guttman, Mitchell; Russell, Pamela; Ingolia, Nicholas T.; Weissman, Jonathan S.; Lander, Eric S.; Lander, Eric S. (Elsevier, 2013-06)
    Large noncoding RNAs are emerging as an important component in cellular regulation. Considerable evidence indicates that these transcripts act directly as functional RNAs rather than through an encoded protein product. ...
  • Lou, Chunbo; Stanton, Brynne; Chen, Ying-Ja; Munsky, Brian; Voigt, Christopher A. (Nature Publishing Group, 2012-10)
    Synthetic genetic programs are built from circuits that integrate sensors and implement temporal control of gene expression. Transcriptional circuits are layered by using promoters to carry the signal between circuits. In ...
  • Spector, Steven Jay; Swint, Reuel B. (Institute of Electrical and Electronics Engineers, 2009-11)
    A mode converter that goes from a rib waveguide to a strip waveguide has been demonstrated. The mode converter contains a 3-D taper fabricated using LOCOS. The demonstrated losses are 0.34 dB per coupler.
  • Costinot, Arnaud; Donaldson, David John (American Economic Association, 2012-05)
    When asked to name one proposition in the social sciences that is both true and non-trivial, Paul Samuelson famously replied: 'Ricardo's theory of comparative advantage'. Truth, however, in Samuelson's reply refers to the ...
  • Colding, Tobias; Minicozzi, William (Springer-Verlag, 2013-02)
    In this paper we generalize the monotonicity formulas of “Colding (Acta Math 209:229–263, 2012)” for manifolds with nonnegative Ricci curvature. Monotone quantities play a key role in analysis and geometry; see, e.g., ...
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