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Browsing MIT Open Access Articles by Title

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  • Geiser, Eveline; Gabrieli, John D. E. (Public Library of Science, 2013-01)
    This study investigated a potential auditory illusion in duration perception induced by rhythmic temporal contexts. Listeners with or without musical training performed a duration discrimination task for a silent period ...
  • Guillemin, Victor W; Miranda, Eva; Pissarra Pires, Ana Rita (Elsevier, 2017-04-21)
    Let M2nM2n be a Poisson manifold with Poisson bivector field Π. We say that M is b -Poisson if the map Πn:M→Λ2n(TM)Πn:M→Λ2n(TM) intersects the zero section transversally on a codimension one submanifold Z⊂MZ⊂M. This paper ...
  • Seidel, Paul; Solomon, Jake P. (Springer-Verlag, 2012-05)
    Given a symplectic cohomology class of degree 1, we define the notion of an “equivariant" Lagrangian submanifold (this roughly corresponds to equivariant coherent sheaves under mirror symmetry). The Floer cohomology of ...
  • Hernandez, David Michael; Bertschinger, Edmund W (Oxford University Press, 2015-07)
    We present a new symplectic integrator designed for collisional gravitational N-body problems which makes use of Kepler solvers. The integrator is also reversible and conserves nine integrals of motion of the N-body problem ...
  • Flint, Rebecca; Coleman, Piers (American Physical Society, 2012-11)
    The possible discovery of s[subscript ±] superconducting gaps in the moderately correlated iron-based superconductors has raised the question of how to properly treat s[subscript ±] gaps in strongly correlated superconductors. ...
  • Cannas da Silva, A.; Guillemin, Victor W.; Pissarra Pires, Ana Rita (Oxford University Press, 2010-12)
    An origami manifold is a manifold equipped with a closed 2-form which is symplectic except on a hypersurface, where it is like the pullback of a symplectic form by a folding map and its kernel fibrates with oriented circle ...
  • Etingof, Pavel I. (Independent University of Moscow, 2012-07)
    The goal of this paper is to present some results and (more importantly) state a number of conjectures suggesting that the representation theory of symplectic reflection algebras for wreath products categorifies certain ...
  • Katerberg, Hilga; Delucchi, Kevin L.; Stewart, S. Evelyn; Lochner, Christine; Denys, Damiaan A. J. P.; Stack, Denise E.; Andresen, Joshua Michael; Grant, J. E.; Kim, Suck W.; Williams, Kyle A.; den Boer, Johan A.; van Balkom, Anton J. L. M.; Smit, Johannes H.; van Oppen, Patricia; Polman, Annemiek; Jenike, Michael A.; Stein, Dan J.; Mathews, Carol A.; Cath, Danielle C. (Springer Science + Business Media B.V., 2010-04)
    To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have ...
  • Melom, Jan Elizabeth; Littleton, J. Troy (Elsevier, 2011-01)
    Recent insights into the genetic basis of neurological disease have led to the hypothesis that molecular pathways involved in synaptic growth, development, and stability are perturbed in a variety of mental disorders. ...
  • Stephan, Matthias T.; Stephan, Sirkka B.; Bak, Peter; Chen, Jianzhu; Irvine, Darrell J. (Elsevier, 2012-05)
    Regulating molecular interactions in the T-cell synapse to prevent autoimmunity or, conversely, to boost anti-tumor immunity has long been a goal in immunotherapy. However, delivering therapeutically meaningful doses of ...
  • Volfson, Dina; Littleton, J. Troy; Vasin, Alexander; Zueva, Lidia; Torrez, Carol; Bykhovskaia, Maria (Society for Neuroscience, 2014-08)
    Patterned depolarization of Drosophila motor neurons can rapidly induce the outgrowth of new synaptic boutons at the larval neuromuscular junction (NMJ), providing a model system to investigate mechanisms underlying acute ...
  • Narayanan, Radhakrishnan; Navratilova, Zaneta; Patel, Chirag; Bohmann, Dirk; Ramaswami, Mani; Jasper, Heinrich; Etter, Paul D. (BioMed Central Ltd, 2005-06)
    Background: The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a positive regulator of growth and ...
  • Scholl, Benjamin; Banerjee, Abhishek (Society for Neuroscience, 2014-07)
    A longstanding goal in neuroscience is to identify and understand synaptic mechanisms underlying the formation of neural circuits that perform sensory computations. Maturation of these circuits proceeds through developmental ...
  • Giusti-Rodriguez, Paola; Gao, Jun; Graff, Johannes; Rei, Damien; Soda, Takahiro; Tsai, Li-Huei (Society for Neuroscience, 2011-11)
    Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloid β (Aβ) accumulation, and progressive neurodegeneration. Cdk5 is a proline-directed ...
  • van Zundert, Brigitte; Zhao, Jiang-Ping; Constantine-Paton, Martha (Wiley-Blackwell Pubishers, 2010-05)
    At the onset of a period of intense synaptic refinement initiated by synchronized eye opening (EO), rapid changes in postsynaptic NMDA receptor and AMPA receptor currents (NMDARcs and AMPARcs) occur within the superficial ...
  • Bear, Mark; Zoghbi, Huda Y. (Cold Spring Harbor Laboratory Press, 2012-01)
    The discovery of the genetic causes of syndromic autism spectrum disorders and intellectual disabilities has greatly informed our understanding of the molecular pathways critical for normal synaptic function. The top-down ...
  • Stevens, Robin J.; Littleton, J. Troy (Elsevier, 2011-05)
    Manipulations of the actin-capping protein adducin in Drosophila and mammalian neurons provide new insights into the mechanisms linking structural changes to synaptic plasticity and learning. Adducin regulates synaptic ...
  • Phillips, Marnie A.; Colonnese, Matthew T.; Goldberg, Julie; Lewis, Laura D.; Brown, Emery N.; Constantine-Paton, Martha (Elsevier, 2011-08)
    The mechanisms by which experience guides refinement of converging afferent pathways are poorly understood. We describe a vision-driven refinement of corticocollicular inputs that determines the consolidation of retinal ...
  • Zhu, Jinwei; Zhou, Qingqing; Shang, Yuan; Li, Hao; Peng, Mengjuan; Ke, Xiao; Weng, Zhuangfeng; Zhang, Rongguang; Huang, Xuhui; Li, Shawn S.C.; Lu, Youming; Zhang, Mingjie; Feng, Guoping (Elsevier, 2017-12)
    The PSD-95/SAPAP/Shank complex functions as the major scaffold in orchestrating the formation and plasticity of the post-synaptic densities (PSDs). We previously demonstrated that the exquisitely specific SAPAP/Shank ...
  • Herrmann, David N.; Horvath, Rita; Sowden, Janet E.; Gonzales, Michael; Sanchez-Mejias, Avencia; Whittaker, Roger G.; Almodovar, Jorge L.; Lane, Maria; Bansagi, Boglarka; Pyle, Angela; Boczonadi, Veronika; Lochmüller, Hanns; Griffin, Helen; Chinnery, Patrick F.; Lloyd, Thomas E.; Zuchner, Stephan; Guan, Zhuo; Littleton, J. Troy (Elsevier B.V., 2014-09)
    Synaptotagmin 2 is a synaptic vesicle protein that functions as a calcium sensor for neurotransmission but has not been previously associated with human disease. Via whole-exome sequencing, we identified heterozygous ...
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