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Browsing MIT Open Access Articles by Title

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  • Kronja, Iva; Yuan, Bingbing; Dzeyk, Kristina; Krijgsveld, Jeroen; Orr-Weaver, Terry L.; Eichhorn, Stephen William; Bartel, David; Orr-Weaver, Terry L. (Elsevier, 2014-05)
    The oocyte-to-embryo transition marks the onset of development. The initial phase of this profound change from the differentiated oocyte to the totipotent embryo occurs in the absence of both transcription and mRNA ...
  • Shalgi, Reut; Hurt, Jessica A.; Lindquist, Susan; Burge, Christopher B. (Elsevier, 2014-05)
    During heat shock and other proteotoxic stresses, cells regulate multiple steps in gene expression in order to globally repress protein synthesis and selectively upregulate stress response proteins. Splicing of several ...
  • Martinez, Asuncion; Tyson, Gene W.; DeLong, Edward (Society for Applied Microbiology and Blackwell Publishing Ltd, 2010-01)
    Phosphonates (Pn), compounds with a direct C–P bond instead of the more common C–O–P ester bond, constitute a significant fraction of marine dissolved organic phosphorus and recent evidence suggests that they may be an ...
  • Peng, Jian; Tucker, George Jay; Leighton, Alexander T.; Berger Leighton, Bonnie (Elsevier, 2015-04)
    How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for ...
  • Kathuria, Satish; Martiny, Adam C.; Berube, Paul M. (United States National Academy of Sciences, 2009-05)
    The marine cyanobacterium Prochlorococcus is the most abundant photosynthetic organism in oligotrophic regions of the oceans. The inability to assimilate nitrate is considered an important factor underlying the distribution ...
  • Shalgi, Reut; Hurt, Jessica A.; Krykbaeva, Irina; Taipale, Mikko; Lindquist, Susan; Burge, Christopher B. (Elsevier B.V., 2013-02)
    Global repression of protein synthesis is a hallmark of the cellular stress response and has been attributed primarily to inhibition of translation initiation, although this mechanism may not always explain the full extent ...
  • Mayr, Christine; Bartel, David (Elsevier, 2009-08)
    In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed without alteration of the proto-oncogene. ...
  • Deng, Shuo; Balakrishnan, Hari; Netravali, Ravi Arun; Sivaraman Kaushalram, Anirudh (Association for Computing Machinery (ACM), 2014-11)
    Over the past two or three years, wireless cellular networks have become faster than before, most notably due to the deployment of LTE, HSPA+, and other similar networks. LTE throughputs can reach many megabits per second ...
  • Barbastathis, George; Oh, Se Baek (Optical Society of America, 2009-08)
    Based on a linear systems approach, we derive the Wigner distribution function (WDF) of a 4f imager with a volume holographic three-dimensional pupil; then we obtain the WDF of the volume hologram itself by using the ...
  • Cui, Zhu-fang; Shi, Chao; Sun, Wei-min; Wang, Yong-long; Zong, Hong-shi (Springer-Verlag, 2014-02)
    By employing some modification to the widely used two-flavor Polyakov-loop extended Nambu–Jona–Lasinio (PNJL) model, we discuss the Wigner solution of the quark gap equation at finite temperature and zero quark chemical ...
  • WikiDo 
    Kushman, Nate; Brodsky, Micah Z. (Micah Zev); Branavan, Satchuthanan R.; Katabi, Dina; Barzilay, Regina; Rinard, Martin C. (Association for Computing Machinery, 2010-10)
    The Internet has allowed collaboration on an unprecedented scale. Wikipedia, Luis Von Ahn’s ESP game, and reCAPTCHA have proven that tasks typically performed by expensive in-house or outsourced teams can instead be delegated ...
  • Hill, Benjamin Mako; Shaw, Aaron (Public Library of Science, 2013-06)
    Opt-in surveys are the most widespread method used to study participation in online communities, but produce biased results in the absence of adjustments for non-response. A 2008 survey conducted by the Wikimedia Foundation ...
  • Zhang, Amy Xian; Verou, Michailia; Karger, David R (Association for Computing Machinery (ACM), 2017-02)
    Large-scale discussions between many participants abound on the internet today, on topics ranging from political arguments to group coordination. But as these discussions grow to tens of thousands of posts, they become ...
  • Fleming, Kermin Elliott; Ng, Man Cheuk; Gross, Samuel; Mithal, Arvind (Institute of Electrical and Electronics Engineers, 2011-05)
    The performance of a wireless system depends on the wireless channel as well as the algorithms used in the transceiver pipelines. Because physical phenomena affect transceiver pipelines in difficult to predict ways, detailed ...
  • Emanuel, Kerry Andrew (American Meteorological Society, 2017-03)
    Hurricane track forecasts have improved steadily over the past few decades, yet forecasting hurricane intensity remains challenging. Of special concern are the rare instances of tropical cyclones that intensify rapidly ...
  • Smith, Merritt Roe (MIT Press, 2009-12)
    Book Review of William Barton Rogers and the Idea of MIT. By A. J. Angulo. (Baltimore: Johns Hopkins University Press, 2009. Pp. xviii, 220. $55.00.)
  • Covert, Thomas; Greenstone, Michael; Knittel, Christopher Roland (American Economic Association, 2016-02)
    Scientists believe significant climate change is unavoidable without a drastic reduction in the emissions of greenhouse gases from the combustion of fossil fuels. However, few countries have implemented comprehensive ...
  • Kochan, Thomas Anton (Sage Publications, inc., 2010-02)
    Every 2 years, staff at the Economic Policy Institute publishes a labor market and employment sourcebook. The State of Working America 2008-2009 is an especially important and valuable contribution. It documents how poorly ...
  • Lander, Eric S.; Aiden, Aviva Presser; Rivera, Miguel N.; Rheinbay, Esther; Ku, Manching; Coffman, Erik J.; Truong, Thanh T.; Vargas, Sara O.; Haber, Daniel A.; Bernstein, Bradley E. (Elsevier, 2010-06)
    Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells (ESCs), ...
  • Cunningham, Daniel P.; Asada, Harry (Institute of Electrical and Electronics Engineers, 2009-07)
    A simple, compact, yet powerful robotic winch, called ldquoWinch-Bot,rdquo is presented in this paper. The Winch-Bot is an underactuated robot having only one controllable axis. Although hanging a load with merely one ...
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