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Browsing MIT Open Access Articles by Title

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  • Movassaghi, Mohammad; Piersanti, Giovanni; Piizzi, Grazia; Siegel, Dustin Scott (American Chemical Society, 2009-11)
    We report our full account of the enantioselective total synthesis of (−)-acylfulvene (1) and (−)-irofulven (2), which features metathesis reactions for the rapid assembly of the molecular framework of these antitumor ...
  • Kwiatkowski, Adam V.; Rubinson, Douglas A.; Dent, Erik W.; Edward van Veen, J.; Leslie, Jonathan D.; Zhang, Jiangyang; Mebane, Leslie Marie; Philippar, Ulrike; Pinheiro, Elaine M.; Burds, Aurora A.; Bronson, Roderick T.; Mori, Susumu; Gertler, Frank; Fassler, Reinhard (Elsevier, 2007-11)
    Mammalian cortical development involves neuronal migration and neuritogenesis; this latter process forms the structural precursors to axons and dendrites. Elucidating the pathways that regulate the cytoskeleton to drive ...
  • Goh, Keow Lin; Cai, Li; Cepko, Constance L.; Gertler, Frank (Elsevier, 2002-04)
    Development of the multilayered cerebral cortex involves extensive regulated migration of neurons arising from the deeper germinative layers of the mammalian brain [1]. The anatomy and formation of the cortical layers has ...
  • Barzik, Melanie; McClain, Leslie Marie; Gupton, Stephanie L.; Gertler, Frank (American Society for Cell Biology, 2014-07)
    Filopodia are long plasma membrane extensions involved in the formation of adhesive, contractile, and protrusive actin-based structures in spreading and migrating cells. Whether filopodia formed by different molecular ...
  • Mobine, Hector R.; Engelmayr, George C.; Moussazadeh, Nelson; Anwar, Tayyba R.; Freed, Lisa E.; Edelman, Elazer R. (Mary Ann Liebert, Inc., 2009-07)
    Pheochromocytomas are widely believed to induce cardiomyopathy via hypersecretion of catecholamines, including norepinephrine (NE). NE can have direct cardiomyocyte toxicity and/or can stimulate myocardial remodeling ...
  • Suntharalingam, Kogularamanan; Lippard, Stephen J.; Zheng, Yaorong; Johnstone, Timothy (Royal Society of Chemistry, The, 2014-11)
    This report presents a novel strategy that facilitates delivery of multiple, specific payloads of Pt(IV) prodrugs using a well-defined supramolecular system. This delivery system comprises a hexanuclear Pt(II) cage that ...
  • Lee, Hyewon; Shapiro, Sarah Jane; Chapin, Stephen Clifford; Doyle, Patrick S (American Chemical Society (ACS), 2016-02)
    In recent years, microRNAs (miRNAs) have emerged as promising diagnostic markers because of their unique dysregulation patterns under various disease conditions and high stability in biological fluids. However, current ...
  • Barthelmes, Dominic; Gränz, Markus; Barthelmes, Katja; Prisner, Thomas; Schwalbe, Harald; Allen, Karen N.; Imperiali, Barbara (Springer Netherlands, 2015-09)
    We recently engineered encodable lanthanide binding tags (LBTs) into proteins and demonstrated their applicability in Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography and luminescence studies. Here, we ...
  • Yarnall, Timothy M.; Abouraddy, Ayman F.; Di Giuseppe, Giovanni; Saleh, Bahaa E. A.; Teich, Malvin C. (American Physical Society, 2012-06)
    Advancing quantum information processing is predicated on the preparation of ever-larger multiqubit states. Photonic realizations of such states may be achieved by increasing the number of photons populating the state or ...
  • Khan, Sheraz; Lefevre, Julien; Baillet, Sylvain; Michmizos, Konstantinos; Ganesan, Santosh; Kitzbichler, Manfred G.; Zetino, Manuel; Hamalainen, Matti S.; Papadelis, Christos; Kenet, Tal (Frontiers Research Foundation, 2014-05)
    Distributed cortical solutions of magnetoencephalography (MEG) and electroencephalography (EEG) exhibit complex spatial and temporal dynamics. The extraction of patterns of interest and dynamic features from these cortical ...
  • Brady, Timothy Francis; Tenenbaum, Joshua B (Cognitive Science Society, 2010)
    When encoding a scene into memory, people store both theoverall gist of the scene and detailed information about a few specific objects. Moreover, they use the gist to guide their choice of which specific ...
  • Stamoulis, Catherine; Richardson, Andrew G. (Springer Science + Business Media B.V., 2010-02)
    Local field potentials (LFPs) measure aggregate neural activity resulting from the coordinated firing of neurons within a local network. We hypothesized that state parameters associated with the underlying brain dynamics ...
  • DeVine, Jessalyn A.; Weichman, Marissa L.; Laws, Benjamin; Chang, Jing; Babin, Mark C.; Balerdi, Garikoitz; Xie, Changjian; Malbon, Christopher L.; Lineberger, W. Carl; Yarkony, David R.; Gibson, Stephen T.; Ma, Jianyi; Guo, Hua; Neumark, Daniel M.; Field, Robert W (American Association for the Advancement of Science (AAAS), 2017-10)
    inylidene-acetylene isomerization is the prototypical example of a 1,2-hydrogen shift, one of the most important classes of isomerization reactions in organic chemistry. This reaction was investigated with quantum state ...
  • Van Leemput, Koen (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper addresses the problem of creating probabilistic brain atlases from manually labeled training data. Probabilistic atlases are typically constructed by counting the relative frequency of occurrence of labels in ...
  • Pipa, Gordon; Lewis, Laura D.; Nikolić, Danko; Williams, Ziv; Brown, Emery N.; Haslinger, Robert Heinz (MIT Press, 2013-08)
    Although the existence of correlated spiking between neurons in a population is well known, the role such correlations play in encoding stimuli is not. We address this question by constructing pattern-based encoding models ...
  • Holcman, D.; Amitai, Assaf (American Physical Society, 2018-03)
    The time for a DNA sequence to find its homologous counterpart depends on a long random search inside the cell nucleus. Using polymer models, we compute here the mean first encounter time (MFET) between two sites located ...
  • Tucker, Catherine Elizabeth; Miller, Amalia R. (Wiley Blackwell, 2011-05)
    Fast-paced IT advances have made it increasingly possible and useful for firms to collect data on their customers on an unprecedented scale. One downside of this is that firms can experience negative publicity and financial ...
  • Ritvo, Harriet (American Association for the Advancement of Science, 2009-03)
  • Nicholson, Anna L.; Olivetti, Elsa A.; Gregory, Jeremy; Field, Frank R.; Kirchain, Randolph E., Jr. (Institute of Electrical and Electronics Engineers, 2009-07)
    Materials selection decisions exhibit great influence on the environmental performance of firms through their impact on processing technology, product form, and supply chain configuration. Consequently, materials dictate ...
  • Godoy, Luiz Claudio; Anderson, Chase T.; Chowdhury, Rajdeep; Trudel, Laura J.; Wogan, Gerald N. (National Academy of Sciences (U.S.), 2012-11)
    Melanoma patients experience inferior survival after biochemotherapy when their tumors contain numerous cells expressing the inducible isoform of NO synthase (iNOS) and elevated levels of nitrotyrosine, a product derived ...
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