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Browsing MIT Open Access Articles by Title

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  • Singh, Victor; Willcox, Karen E (American Institute of Aeronautics and Astronautics, 2018-01)
    Digital Thread offers the opportunity to use information generated across the product lifecycle to design the next generation of products. In this paper, we introduce a mathematical methodology that establishes the data-driven ...
  • Zhang, Haoran; Li, Zhengjun; Stephanopoulos, Gregory; Pereira, Brian J. (BioMed Central Ltd., 2015-09)
    Background cis, cis-Muconic acid is an important chemical that can be biosynthesized from simple substrates in engineered microorganisms. Recently, it has been shown that engineering microbial cocultures is an emerging ...
  • Dhamankar, Himanshu; Tarasova, Yekaterina; Martin, Collin H.; Prather, Kristala L. Jones (Elsevier, 2014-06)
    3-hydroxy-γ-butyrolactone (3HBL) is a versatile chiral synthon, deemed a top value-added chemical from biomass by the DOE. We recently reported the first biosynthetic pathway towards 3HBL and its hydrolyzed form, ...
  • Nigmatulina, Karima; Finkelstein, Stan Neil; Larson, Richard Charles; Teytelman, Anna (Institute for Operations Research and the Management Sciences (INFORMS), 2015-05)
    We present a policy-oriented summary of our six-year "service-systems-focused" research into pandemic influenza. We cover three topics: (1) R[subscript 0], the basic reproductive number for the flu; (2) NPIs, non-pharmaceutical ...
  • Barthelmes, Katja; Reynolds, Anne M.; Peisach, Ezra; Jonker, Hendrik R. A.; DeNunzio, Nicholas J.; Allen, Karen N.; Imperiali, Barbara; Schwalbe, Harald (American Chemical Society, 2010-12)
    Lanthanide-binding tags (LBTs) are valuable tools for investigation of protein structure, function, and dynamics by NMR spectroscopy, X-ray crystallography, and luminescence studies. We have inserted LBTs into three different ...
  • Jeng, Lily; Olsen, Bjorn R.; Spector, Myron (Mary Ann Liebert, 2010-06)
    Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like ...
  • Lippow, Shaun M.; Moon, Tae Seok; Basu, Subhayu; Yoon, Sang-Hwal; Li, Xiazhen; Chapman, Brad A.; Robison, Keith; Lipovšek, Daša; Prather, Kristala L. Jones (Elsevier, 2010-12)
    Engineered biosynthetic pathways have the potential to produce high-value molecules from inexpensive feedstocks, but a key limitation is engineering enzymes with high activity and specificity for new reactions. Here, we ...
  • Zhang, Haoran; Li, Zhengjun; Stephanopoulos, Gregory; Pereira, Brian J. (National Academy of Sciences (U.S.), 2015-07)
    Engineering microbial consortia to express complex biosynthetic pathways efficiently for the production of valuable compounds is a promising approach for metabolic engineering and synthetic biology. Here, we report the ...
  • Dai, Shou-Huang; Maity, Debaprasad; Zhang, Yun-Long; Chen, Jiunn-Wei (American Physical Society, 2016-10)
    By introducing interacting scalar fields, we tried to engineer physically motivated holographic phase diagrams which may be interesting in the context of various known condensed matter systems. We introduce an additional ...
  • Drake, Adam; Chen, Jianzhu; Chen, Qingfeng (Nature Publishing Group, 2012-05)
    Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse. This article reviews recent advances in the ...
  • Manzardo, Marco; Efremov, Dmitry V.; van den Brink, Jeroen; Ortix, Carmine; Venderbos, Jorn W. F. (American Physical Society, 2016-01)
    We consider a system of spinless fermions on the honeycomb lattice with substrate-induced modulated electrostatic potentials tripling the unit cell. The resulting non-Abelian SU(2) gauge fields act cooperatively to realize ...
  • Matsumoto, Yuri; Chen, Ritchie; Anikeeva, Polina Olegovna; Jasanoff, Alan Pradip (Nature Publishing Group, 2015-11)
    Remote measurement and manipulation of biological systems can be achieved using magnetic techniques, but a missing link is the availability of highly magnetic handles on cellular or molecular function. Here we address this ...
  • Griffith, Linda G.; Wells, Alan; Stolz, Donna B. (Wiley Blackwell, 2014-05)
    Interest in “engineering liver” arises from multiple communities: therapeutic replacement; mechanistic models of human processes; and drug safety and efficacy studies. An explosion of micro- and nanofabrication, biomaterials, ...
  • Chen, Allen Y.; Zhong, Chao; Lu, Timothy K. (American Chemical Society (ACS), 2015-01)
    Natural materials, such as bone, integrate living cells composed of organic molecules together with inorganic components. This enables combinations of functionalities, such as mechanical strength and the ability to regenerate ...
  • Dy, Aaron James; Collins, James J. (Elsevier B.V., 2016-04)
    Main Text The physicist Richard Feynman famously wrote, “What I cannot create, I do not understand,” at the top of his final blackboard. This philosophy has inspired many in the emerging field of synthetic biology, which ...
  • Pires, Diana P.; Ando, Hiroki; Lemire, Sebastien; Lu, Timothy K (Elsevier, 2015-09)
    Bacteria are central to human health and disease, but existing tools to edit microbial consortia are limited. For example, broad-spectrum antibiotics are unable to precisely manipulate bacterial communities. Bacteriophages ...
  • Moon, James J.; Huang, Bonnie; Irvine, Darrell J. (Wiley Blackwell, 2012-05)
    The immune system can be a cure or cause of disease, fulfilling a protective role in attacking cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders. Thus, therapies aimed to amplify or ...
  • Irvine, D. J.; Mehta, Naveen; Moynihan, Kelly Dare (American Association for Cancer Research (AACR), 2015-08)
    Recently, a number of promising approaches have been developed using synthetic chemistry, materials science, and bioengineering-based strategies to address challenges in the design of more effective cancer vaccines. At the ...
  • Prather, Kristala L. Jones; Bower, Diana Morgan (Springer Berlin Heidelberg, 2009-02)
    The demand for plasmid DNA (pDNA) is anticipated to increase significantly as DNA vaccines and non-viral gene therapies enter phase 3 clinical trials and are approved for use. This increased demand, along with renewed ...
  • Davis, Mark E.; Langer, Robert S (National Academy of Sciences (U.S.), 2015-11)
    In celebration of the 100th Anniversary of PNAS, this Special Feature summarizes the enormous progress that has been made in the engineering of biology and medicine. In 1915, PNAS published articles, such as “A comparison ...
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