Now showing items 29043-29062 of 32185

    • T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis 

      Cemerski, Saso; Delgado, Pilar; Turner, Martin; Heuser, John; Irvine, Darrell J.; e.a. (Elsevier, 2011-08)
      The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated ...
    • T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity 

      Schmid, Daniela; Park, Chun Gwon; Hartl, Christina A.; Subedi, Nikita; Cartwright, Adam N.; e.a. (Nature Publishing Group, 2017-11)
      Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because attempts to target tumors directly have yielded limited benefit, we ...
    • T(ether): spatially-aware handhelds, gestures and proprioception for multi-user 3D modeling and animation 

      Perlin, Ken; Lakatos, David; Blackshaw, Matthew Andrew; Okot-Olwal, Alex Wilson Alphonse; Barryte, Zachary B.; e.a. (2014-10)
      T(ether) is a spatially-aware display system for multi-user, collaborative manipulation and animation of virtual 3D objects. The handheld display acts as a window into virtual reality, providing users with a perspective ...
    • T(T,2n)[superscript 4]He and [superscript 3]He([superscript 3]He,2p)[superscript 4]He: The Reaction Mechanism from Solar Energies to 10 MeV* 

      Bacher, A.D.; Brune, C.R; Sayre, D.B.; Hale, G.M.; Frenje, J.A.; e.a. (EDP Sciences, 2016-03)
      We have studied the energy dependence of the reaction mechanism of the T(t,2n)[superscript 4] He reaction at stellar energies and of its charge symmetric analog reaction [superscript 3]He([superscript 3]He,2p)[superscript ...
    • T-cell death following immune activation is mediated by mitochondria-localized SARM 

      Panneerselvam, P.; Singh, L. P.; Selvarajan, V.; Chng, W. J.; Ng, S. B.; e.a. (Nature Publishing Group, 2012-11)
      Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile α- and heat armadillo-motif ...
    • T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell 

      Serwold, T.; Hochedlinger, K.; Swindle, J.; Hedgpeth, J.; Weissman, I. L.; e.a. (National Academy of Sciences (U.S.), 2010-11)
      The conversion of mature somatic cells into pluripotent stem cells, both by nuclear transfer and transduction with specific “reprogramming” genes, represents a major advance in regenerative medicine. Pluripotent stem cell ...
    • T-duality constraints on higher derivatives revisited 

      Hohm, Olaf; Zwiebach, Barton (Springer Berlin Heidelberg, 2016-04)
      We ask to what extent are the higher-derivative corrections of string theory constrained by T-duality. The seminal early work by Meissner tests T-duality by reduction to one dimension using a distinguished choice of field ...
    • TABASCO: A single molecule, base-pair resolved gene expression simulator 

      Kosuri, Sriram; Endy, Drew; Kelly, Jason R. (BioMed Central Ltd, 2007-12)
      Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior. Given our current understanding of gene ...
    • Tachyon: Reliable, Memory Speed Storage for Cluster Computing Frameworks 

      Li, Haoyuan; Ghodsi, Ali; Shenker, Scott; Stoica, Ion; Zaharia, Matei A. (Association for Computing Machinery (ACM), 2014-11)
      Tachyon is a distributed file system enabling reliable data sharing at memory speed across cluster computing frameworks. While caching today improves read workloads, writes are either network or disk bound, as replication ...
    • Tackling the cancer stem cells — what challenges do they pose? 

      Pattabiraman, Diwakar R.; Weinberg, Robert A (Nature Publishing Group, 2014-07)
      Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive study. Their properties and mechanisms of formation have become a major focus of current cancer research, in part because of their ...
    • Tactile robotic mapping of unknown surfaces: An application to oil well exploration 

      Mazzini, Francesco; Kettler, Daniel; Dubowsky, Steven; Guerrero, Julio Cesar (Institute of Electrical and Electronics Engineers, 2009-12)
      World oil demand and advanced oil recovery techniques have made it economically attractive to rehabilitate previously abandoned oil wells. This requires relatively fast mapping of the shape and location of the down-hole ...
    • Tagalong: Informal Learning from a Remote Companion with Mobile Perspective Sharing 

      Greenwald, Scott Wilkins; Khan, Mina; Vazquez Machado, Christian David; Maes, Patricia (International Association for Development of the Information Society (IADIS), 2015-10)
      Questions often arise spontaneously in a curious mind, due to an observation about a new or unknown environment. When an expert is right there, prepared to engage in dialog, this curiosity can be harnessed and converted ...
    • Tagging and Targeting of Energy Efficiency Subsidies 

      Allcott, Hunt; Taubinsky, Dmitry; Knittel, Christopher Roland (American Economic Association, 2015-05)
      A corrective tax or subsidy is "well-targeted" if it primarily affects choices that are more distorted by market failures. Energy efficiency subsidies are designed to correct multiple distortions: externalities, credit ...
    • TagMe: an easy-to-use toolkit for turning the personal environment into an extended communications interface 

      Benavides Palos, Xavier; Amores Fernandez, Judith; Maes, Patricia (Association for Computing Machinery, 2014-04)
      In this paper we present an end-user toolkit for easy creation of responsive objects and environments. TagMe consists of a wearable device that recognizes the object or surface the user is touching. The user can make ...
    • Tailbench: a benchmark suite and evaluation methodology for latency-critical applications 

      Kasture, Harshad; Sanchez, Daniel (Institute of Electrical and Electronics Engineers (IEEE), 2016-09)
      Latency-critical applications, common in datacenters, must achieve small and predictable tail (e.g., 95th or 99th percentile) latencies. Their strict performance requirements limit utilization and efficiency in current ...
    • Tailorable stimulated Brillouin scattering in nanoscale silicon waveguides 

      Shin, Heedeuk; Qiu, Wenjun; Jarecki, Robert; Cox, Jonathan A.; Olsson, Roy H.; e.a. (Nature Publishing Group, 2013-06)
      Nanoscale modal confinement is known to radically enhance the effect of intrinsic Kerr and Raman nonlinearities within nanophotonic silicon waveguides. By contrast, stimulated Brillouin-scattering nonlinearities, which ...
    • Tailored Codes for Small Quantum Memories 

      Robertson, Alan; Granade, Christopher; Bartlett, Stephen D.; Flammia, Steven Thomas (American Physical Society, 2017-12)
      We demonstrate that small quantum memories, realized via quantum error correction in multiqubit devices, can benefit substantially by choosing a quantum code that is tailored to the relevant error model of the system. For ...
    • Tailored displays to compensate for visual aberrations 

      Pamplona, Vitor F.; Oliveira, Manuel M.; Aliaga, Daniel G.; Raskar, Ramesh (Association for Computing Machinery, 2012-07)
      We introduce tailored displays that enhance visual acuity by decomposing virtual objects and placing the resulting anisotropic pieces into the subject's focal range. The goal is to free the viewer from needing wearable ...
    • Tailoring and cancelling dispersion of slow or stopped and subwavelength surface-plasmonodielectric-polaritonic light 

      Soljacic, Marin; Karalis, Aristeidis; Joannopoulos, John D. (Society of Photo-Optical Instrumentation Engineers, 2009-02)
      A new physical mechanism enabling simultaneous cancellation of group-velocity and attenuation dispersion to extremely high orders for subwavelength light of any small positive, negative or zero value of the group velocity ...
    • Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions 

      Krueger, Andrew T.; Kroll, Carsten; Sanchez, Edgar; Griffith, Linda G.; Imperiali, Barbara (Wiley Blackwell, 2014-01)
      Described is the development and application of a versatile semisynthetic strategy, based on a combination of sortase-mediated coupling and tetrazine ligation chemistry, which can be exploited for the efficient incorporation ...