Now showing items 32193-32212 of 32314

    • Y-family DNA polymerases in Escherichia coli 

      Jarosz, Daniel F.; Beuning, Penny J.; Cohen, Susan E.; Walker, Graham C. (Elsevier, 2007-01)
      The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ...
    • Y[subscript MAP]: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens 

      Abbey, Darren A.; Funt, Jason; Lurie-Weinberger, Mor N.; Thompson, Dawn A.; Regev, Aviv; e.a. (BioMed Central Ltd, 2014-11)
      The design of effective antimicrobial therapies for serious eukaryotic pathogens requires a clear understanding of their highly variable genomes. To facilitate analysis of copy number variations, single nucleotide polymorphisms ...
    • YabA of Bacillus subtilis controls DnaA-mediated replication initiation but not the transcriptional response to replication stress 

      Goranov, Alexi I.; Breier, Adam M.; Merrikh, Houra; Grossman, Alan D. (Blackwell Publishing, 2009-09)
      yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other Gram-positive species. YabA interacts with the β-processivity clamp (DnaN) of DNA polymerase and with ...
    • Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase 

      Puthenveetil, Sujiet; Liu, Daniel S.; White, Katharine Alice; Thompson, Samuel M.; Ting, Alice Y. (American Chemical Society, 2009-10)
      Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three acceptor proteins involved in oxidative metabolism. Our lab has shown that LplA ...
    • A Yeast Model of FUS/TLS-Dependent Cytotoxicity 

      Ju, Shulin; Tardiff, Daniel F.; Han, Haesun; Divya, Kanneganti; Zhong, Quan; e.a. (Public Library of Science, 2011-04)
      FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ...
    • Yeast Reveal a ‘Druggable’ Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons 

      Jui, Nathan T.; Buchwald, Stephen Leffler; Lindquist, Susan; Tardiff, Daniel F.; Khurana, Vikram; e.a. (American Association for the Advancement of Science (AAAS), 2013-10)
      α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these ...
    • Yield Hardening of Electrorheological Fluids in Channel Flow 

      Helal, Ahmed H.; Qian, Bian; McKinley, Gareth H; Hosoi, Anette E (American Physical Society, 2016-06)
      Electrorheological fluids offer potential for developing rapidly actuated hydraulic devices where shear forces or pressure-driven flow are present. In this study, the Bingham yield stress of electrorheological fluids with ...
    • Yield stress in metallic glasses: The jamming-unjamming transition studied through Monte Carlo simulations based on the activation-relaxation technique 

      Rodney, David; Schuh, Christopher A. (American Physical Society, 2009-11)
      A Monte Carlo approach allowing for stress control is employed to study the yield stress of a two-dimensional metallic glass in the limit of low temperatures and long (infinite) time scales. The elementary thermally activated ...
    • Yield-driven iterative robust circuit optimization algorithm 

      Li, Yan; Stojanovic, Vladimir Marko (Institute of Electrical and Electronics Engineers, 2009-08)
      This paper proposes an equation-based multi-scenario iterative robust optimization methodology for analog/mixed-signal circuits. We show that due to local circuit performance monotonicity in random variations constraint ...
    • Yields and production rates of cosmogenic [superscript 9]Li and [superscript 8]He measured with the Double Chooz near and far detectors 

      de Kerret, H.; Abrahão, T.; Almazan, H.; dos Anjos, J. C; Appel, S.; e.a. (Springer Berlin Heidelberg, 2018-11)
      The yields and production rates of the radioisotopes [superscript 9]Li and [superscript 8]He created by cosmic muon spallation on [superscript 12]C, have been measured by the two detectors of the Double Chooz experiment. ...
    • You get what you pay for: Schooling incentives and child labor 

      Edmonds, Eric V.; Shrestha, Maheshwor (Elsevier, 2014-10)
      Can schooling promotion deter child participation in hazardous forms of child labor? We examine two interventions intended to promote schooling and deter child labor for children associated with carpet factories in Kathmandu. ...
    • You just believe that because... 

      White, Roger (Wiley-Blackwell Pubishers, 2010-12)
      1. Introduction I believe that Tom is the proud father of a baby boy. Why do I think his child is a boy? A natural answer might be that I remember that his name is ‘Owen’ which is usually a boy’s name. Here I’ve given ...
    • You Too?! Mixed-Initiative LDA Story Matching to Help Teens in Distress 

      Dinakar, Karthik; Jones, Birago; Lieberman, Henry A.; Picard, Rosalind W.; Rose, Carolyn; e.a. (Association for the Advancement of Artificial Intelligence, 2012-06)
      Adolescent cyber-bullying on social networks is a phenomenon that has received widespread attention. Recent work by sociologists has examined this phenomenon under the larger context of teenage drama and it's manifestations ...
    • Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks 

      Zhuo, Jia-Min; Tseng, Hua-an; Desai, Mitul; Bucklin, Mark E; Mohammed, Ali I; e.a. (eLife Sciences Publications, Ltd., 2016-12)
      Adult neurogenesis supports performance in many hippocampal dependent tasks. Considering the small number of adult-born neurons generated at any given time, it is surprising that this sparse population of cells can ...
    • Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive 

      Lamming, Dudley W.; Ye, Lan; Astle, Clinton M.; Baur, Joseph A.; Sabatini, David M.; e.a. (Wiley Blackwell, 2013-06)
      Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, extends the life span of yeast, worms, flies, and mice. Interventions that promote longevity are often correlated with increased ...
    • The Young Bouquet and Its Boundary 

      Borodin, Alexei; Olshanski, Grigori (Independent University of Moscow, 2013-04)
      The classification results for the extreme characters of two basic “big” groups, the infinite symmetric group S(∞) and the infinite-dimensional unitary group U(∞), are remarkably similar. It does not seem to be possible ...
    • Young Children Treat Robots as Informants 

      Harris, Paul L.; DeSteno, David; Dickens, Leah; Breazeal, Cynthia L.; Kory Westlund, Jacqueline Marie; e.a. (Wiley Blackwell, 2016-04)
      Children ranging from 3 to 5 years were introduced to two anthropomorphic robots that provided them with information about unfamiliar animals. Children treated the robots as interlocutors. They supplied information to the ...
    • Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion 

      Nakashiba, Toshiaki; Cushman, Jesse D.; Pelkey, Kenneth A.; Renaudineau, Sophie; Buhl, Derek L.; e.a. (Elsevier B.V., 2012-03)
      Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from ...
    • YOUNG “DIPPER” STARS IN UPPER SCO AND OPH OBSERVED BY K2 

      Ansdell, M.; Gaidos, E.; Jacobs, T. L.; LaCourse, D. M.; Jek, K. J.; e.a. (IOP Publishing, 2016-01)
      We present ten young ([< over ~]10 Myr) late-K and M dwarf stars observed in K2 Campaign 2 that host protoplanetary disks and exhibit quasi-periodic or aperiodic dimming events. Their optical light curves show ~10–20 dips ...
    • THE YOUNGEST KNOWN X-RAY BINARY: CIRCINUS X-1 AND ITS NATAL SUPERNOVA REMNANT 

      Heinz, Sebastian; Sell, P.; Fender, R. P.; Jonker, P. G.; Brandt, W. N.; e.a. (Institute of Physics/American Astronomical Society, 2013-12)
      Because supernova remnants are short-lived, studies of neutron star X-ray binaries within supernova remnants probe the earliest stages in the life of accreting neutron stars. However, such objects are exceedingly rare: ...