Now showing items 16202-16221 of 34027

    • LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins 

      Sosa, Brian A.; Rothballer, Andrea; Kutay, Ulrike; Schwartz, Thomas; Sosa, Brian A. (Elsevier, 2012-05)
      Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC formation relies on direct ...
    • LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining 

      Lawrence, Katherine S.; Tapley, Erin C.; Cruz, Victor E.; Li, Qianyan; Aung, Kayla; e.a. (Rockefeller University Press, 2016-12)
      The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA damage repair and meiotic recombination. Loss of UNC-84 leads ...
    • LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint 

      Sarma, Kavitha; Lee, Jeannie T.; Dimitrova, Nadya; Zamudio, Jesse Ray; Jong, Robyn; e.a. (Elsevier, 2014-05)
      The p53-regulated long noncoding RNA lincRNA-p21 has been proposed to act in trans via several mechanisms ranging from repressing genes in the p53 transcriptional network to regulating mRNA translation and protein stability. ...
    • lincRNAs act in the circuitry controlling pluripotency and differentiation 

      Guttman, Mitchell; Donaghey, Julie; Carey, Bryce W.; Garber, Manuel; Grenier, Jennifer K.; e.a. (Nature Publishing Group, 2011-08)
      Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in mammals, few have been functionally characterized, leading to debate about their biological role. To address this, we performed ...
    • lincRNAs: Genomics, Evolution, and Mechanisms 

      Ulitsky, Igor; Bartel, David (Elsevier, 2013-07)
      Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and other cellular processes. This Review outlines the emerging ...
    • Line complexity asymptotics of polynomial cellular automata 

      Stone, Bertrand; Stone, Bertrand A. (Springer US, 2018-11)
      Cellular automata are discrete dynamical systems that consist of patterns of symbols on a grid, which change according to a locally determined transition rule. In this paper, we will consider cellular automata that arise ...
    • A Line of Sages 

      Khovanova, Tanya (Springer US, 2013-11)
      A new variation of an old hat puzzle, where sages are standing in line one behind the other. This column is a place for those bits of contagious mathematics that travel from person to person in the community, because ...
    • Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging 

      Zhang, Jitao; Fiore, Antonio; Kim, Hanyoup; Scarcelli, Giuliano; Yun, Seok Hyun (Andy) (Nature Publishing Group, 2016-10)
      Brillouin spectroscopy probes the mechanical properties of material by measuring the optical frequency shift induced by photon-phonon scattering interactions. In traditional configurations, Brillouin spectrometers measure ...
    • Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration 

      Trompouki, Eirini; Bowman, Teresa V.; Lawton, Lee N.; Fan, Zi Peng; Wu, Dai-Chen; e.a. (Elsevier B.V., 2011-10)
      BMP and Wnt signaling pathways control essential cellular responses through activation of the transcription factors SMAD (BMP) and TCF (Wnt). Here, we show that regeneration of hematopoietic lineages following acute injury ...
    • Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics 

      Regev, Aviv (Elsevier BV, 2019-03)
      Lineage tracing provides key insights into the fate of individual cells in complex organisms. Although effective genetic labeling approaches are available in model systems, in humans, most approaches require detection of ...
    • Lineage-based identification of cellular states and expression programs 

      Hashimoto, Tatsunori Benjamin; Jaakkola, Tommi S.; Sherwood, Richard; Mazzoni, Esteban O.; Wichterle, Hynek; e.a. (Oxford University Press, 2012-01)
      We present a method, LineageProgram, that uses the developmental lineage relationship of observed gene expression measurements to improve the learning of developmentally relevant cellular states and expression programs. ...
    • Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer 

      Kurklu, B; Whitehead, R H; Ong, E K; Minamoto, T; Mann, J R; e.a. (Nature Publishing Group, 2014-08)
      Runt domain transcription factor 3 (RUNX3) is widely regarded as a tumour-suppressor gene inactivated by DNA hypermethylation of its canonical CpG (cytidine-phosphate-guanidine) island (CGI) promoter in gastric cancer (GC). ...
    • Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia 

      Pierce, Eric T.; Harrell, P. Grace; Walsh, John; Salazar, Andres F.; Tavares, Casie L.; e.a. (Institute of Electrical and Electronics Engineers, 2009-11)
      Quantitative evaluation of respiratory sinus arrhythmia (RSA) may provide important information in clinical practice of anesthesia and postoperative care. In this paper, we apply a point process method to assess dynamic ...
    • Linear Bellman combination for control of character animation 

      da Silva, Marco; Durand, Fredo; Popovic, Jovan (Association for Computing Machinery (ACM), 2009-08)
      Controllers are necessary for physically-based synthesis of character animation. However, creating controllers requires either manual tuning or expensive computer optimization. We introduce linear Bellman combination as a ...
    • Linear Dimensionality Reduction for Margin-Based Classification: High-Dimensional Data and Sensor Networks 

      Varshney, Kush R.; Willsky, Alan S.; Willsky, Alan (Institute of Electrical and Electronics Engineers, 2011-06)
      Low-dimensional statistics of measurements play an important role in detection problems, including those encountered in sensor networks. In this work, we focus on learning low-dimensional linear statistics of high-dimensional ...
    • Linear growth for semigroups which are disjoint unions of finitely many copies of the free monogenic semigroup 

      Abughazalah, Nabilah; Etingof, Pavel I. (Springer Basel, 2015-08)
      We show that every semigroup which is a finite disjoint union of copies of the free monogenic semigroup (natural numbers under addition) has linear growth. This implies that the corresponding semigroup algebra is a PI algebra.
    • Linear information coupling problems 

      Huang, Shao-Lun; Zheng, Lizhong (Institute of Electrical and Electronics Engineers (IEEE), 2012-07)
      Many network information theory problems face the similar difficulty of single letterization. We argue that this is due to the lack of a geometric structure on the space of probability distribution. In this paper, we develop ...
    • Linear magnetoresistance in metals: Guiding center diffusion in a smooth random potential 

      Song, Justin C. W.; Refael, Gil; Lee, Patrick A. (American Physical Society, 2015-11)
      We predict that guiding center (GC) diffusion yields a linear and nonsaturating (transverse) magnetoresistance in 3D metals. Our theory is semiclassical and applies in the regime where the transport time is much greater ...
    • Linear Matrix Inequalities for Physically Consistent Inertial Parameter Identification: A Statistical Perspective on the Mass Distribution 

      Wensing, Patrick M.; Kim, Sangbae; Slotine, Jean-Jacques E (Institute of Electrical and Electronics Engineers (IEEE), 2017-07)
      With the increased application of model-based whole-body control in legged robots, there has been a resurgence of research interest into methods for accurate system identification. An important class of methods focuses on ...
    • Linear Motor Powered Transportation 

      Thornton, Richard D.; Fang, Jiarong; Perreault, Brian M.; Thompson, Marc T. (Institute of Electrical and Electronics Engineers, 2009-10)
      This special issue on linear-motor powered transportation covers both supporting technologies and innovative transport systems in various parts of the World, as this technology moves from the lab to commercial operations. ...