Now showing items 18826-18845 of 34551

    • Microneedle‐based intradermal delivery of stabilized dengue virus 

      Turvey, Michelle E.; Uppu, Divakara S.S.M.; Mohamed Sharif, Abdul Rahim; Bidet, Katell; Alonso, Sylvie; e.a. (Wiley, 2019-02)
      Current live-attenuated dengue vaccines require strict cold chain storage. Methods to preserve dengue virus (DENV) viability, which enable vaccines to be transported and administered at ambient temperatures, will be decisive ...
    • Microparticles prepared from biodegradable polyhydroxyalkanoates as matrix for encapsulation of cytostatic drug 

      Murueva, A. V.; Shishatskaya, E. I.; Kuzmina, A. M.; Volova, T. G.; Sinskey, Anthony J (Springer US, 2013-05)
      Microparticles made from degradable polyhydroxyalkanoates of different chemical compositions a homopolymer of 3-hydroxybutyric acid, copolymers of 3-hydroxybutyric and 4-hydroxybutyric acids (P3HB/4HB), 3-hydroxybutyric ...
    • Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues 

      Li, Cheri Yingjie; Stevens, Kelly R.; Schwartz, Robert E.; Alejandro, Brian S.; Huang, Joanne H.; e.a. (Mary Ann Liebert, Inc., 2014-04)
      Drug-induced liver injury is a major cause of drug development failures and postmarket withdrawals. In vitro models that incorporate primary hepatocytes have been shown to be more predictive than model systems which rely ...
    • Micropatterned comet assay enables high throughput and sensitive DNA damage quantification 

      Engelward, B. P.; Ge, Jing; Chow, Danielle N.; Fessler, Jessica L.; Weingeist, David M.; e.a. (Oxford University Press, 2014-12)
      The single cell gel electrophoresis assay, also known as the comet assay, is a versatile method for measuring many classes of DNA damage, including base damage, abasic sites, single strand breaks and double strand breaks. ...
    • Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons 

      Osaki, Tatsuya; Uzel, Sebastien GM; Kamm, Roger Dale (American Association for the Advancement of Science (AAAS), 2018-10)
      Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much research effort. To provide a platform ...
    • A microphysiological system model of therapy for liver micrometastases 

      Clark, Amanda M.; Wheeler, Sarah E.; Taylor, Donald P.; Pillai, Venkateswaran C.; Young, Carissa L.; e.a. (Royal Society of Medicine, 2014-05)
      Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors ...
    • Microphytoplankton variations during coral spawning at Los Roques, Southern Caribbean 

      Cavada-Blanco, Francoise; Zubillaga, Ainhoa L.; Bastidas, Ana Carolina (PeerJ Inc., 2016-03)
      Phytoplankton drives primary productivity in marine pelagic systems. This is also true for the oligotrophic waters in coral reefs, where natural and anthropogenic sources of nutrients can alter pelagic trophic webs. In ...
    • Micropillar compression testing of powders 

      Huskins, Emily L.; Schuster, Brian E.; Cordero, Zachary Copoulos; Schuh, Christopher A (Springer US, 2015-07)
      An experimental design for microcompression on individual powder particles is proposed as a means of testing novel materials without the challenges associated with consolidation to produce bulk specimens. This framework ...
    • A Microporous and Naturally Nanostructured Thermoelectric Metal-Organic Framework with Ultralow Thermal Conductivity 

      Stach, Eric A.; Zakharov, Dmitri; Stavila, Vitalie; Talin, A. Alec; Ge, Yicong; e.a. (Elsevier, 2017-09)
      Microporous metal-organic frameworks (MOFs) offer attributes that make them potentially compelling choices for thermoelectric applications because they combine organic character with long-range order and intrinsically low ...
    • A micropower electrocardiogram amplifier 

      Sarpeshkar, Rahul; Fay, Leon; Misra, Vinith (Institute of Electrical and Electronics Engineers, 2009-09)
      We introduce an electrocardiogram (EKG) preamplifier with a power consumption of 2.8 muW, 8.1 muV[subscript rms] input-referred noise, and a common-mode rejection ratio of 90 dB. Compared to previously reported work, this ...
    • A micropower support vector machine based seizure detection architecture embedded medical devices 

      Denison, Timothy; Panken, Eric; Carlson, Dave; Shoeb, Ali H. (Institute of Electrical and Electronics Engineers, 2009-11)
      Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
    • A micropower support vector machine based seizure detection architecture for embedded medical devices 

      Shoeb, Ali H.; Carlson, Dave; Panken, Eric; Denison, Timothy (Institute of Electrical and Electronics Engineers, 2009-11)
      Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
    • Microquake seismic interferometry with SVD-enhanced Green's function recovery 

      Melo, Gabriela; Malcolm, Alison E. (Society of Exploration Geophysicists, 2011-05)
      The conditions under which seismic interferometry (SI) leads to the exact Green's function (GF) are rarely met in practice. As a result, we generally recover only estimates of the true GF. This raises the questions: How ...
    • MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation 

      Papangeli, Irinna; Kim, Jongmin; Maier, Inna; Park, Saejeong; Lee, Aram; e.a. (Nature Publishing Group, 2016-04)
      G protein-coupled receptor (GPCR) signalling, including that involving apelin (APLN) and its receptor APLNR, is known to be important in vascular development. How this ligand–receptor pair regulates the downstream signalling ...
    • MicroRNA and gene expression changes in unruptured human cerebral aneurysms 

      Bekelis, Kimon; Kerley-Hamilton, Joanna S.; Teegarden, Amy; Tomlinson, Craig R.; Kuintzle, Rachael; e.a. (American Association of Neurological Surgeons, 2016-12)
      OBJECTIVE The molecular mechanisms behind cerebral aneurysm formation and rupture remain poorly understood. In the past decade, microRNAs (miRNAs) have been shown to be key regulators in a host of biological processes. ...
    • MicroRNA Control of TGF-β Signaling 

      Suzuki, Hiroshi (MDPI AG, 2018-06)
      Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small regulatory RNAs that are approximately 22 ...
    • MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes 

      Rissland, Olivia S.; Hong, Sue-Jean; Bartel, David; Rissland, Olivia S. (Elsevier B.V., 2011-09)
      The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the ...
    • MicroRNA Functions in Stress Responses 

      Leung, Anthony; Sharp, Phillip A. (Elsevier B.V., 2010-10)
      MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding ...
    • MicroRNA miR-125b causes leukemia 

      Bousquet, Marina; Harris, Marian H.; Zhou, Beiyan; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2010-12)
      MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of ...
    • A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory 

      Mathew, Rebecca S; Tatarakis, Antonis; Johnson-Venkatesh, Erin M; Murphy, Elisabeth A; Todd, Travis P; e.a. (eLife Sciences Publications, Ltd., 2016-12)
      The SNARE-mediated vesicular transport pathway plays major roles in synaptic remodeling associated with formation of long-term memories, but the mechanisms that regulate this pathway during memory acquisition are not fully ...