Browsing MIT Open Access Articles by Title
Now showing items 19244-19263 of 55780
-
Gene duplication and the evolution of ribosomal protein gene regulation in yeast
(National Academy of Sciences (U.S.), 2010-03)Coexpression of genes within a functional module can be conserved at great evolutionary distances, whereas the associated regulatory mechanisms can substantially diverge. For example, ribosomal protein (RP) genes are tightly ... -
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
(Elsevier BV, 2017-02)The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based ... -
Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures
(BioMed Central, 2015-12)Background Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes ... -
A gene expression atlas of embryonic neurogenesis in Drosophila reveals complex spatiotemporal regulation of lncRNAs
(The Company of Biologists, 2019-03)Cell type specification during early nervous system development in Drosophila melanogaster requires precise regulation of gene expression in time and space. Resolving the programs driving neurogenesis has been a major ... -
Gene Expression Changes in the Motor Cortex Mediating Motor Skill Learning
(Public Library of Science, 2013-04)The primary motor cortex (M1) supports motor skill learning, yet little is known about the genes that contribute to motor cortical plasticity. Such knowledge could identify candidate molecules whose targeting might enable ... -
Gene Expression Correlates of the Cortical Network Underlying Sentence Processing
(MIT Press - Journals, 2020)<jats:p> A pivotal question in modern neuroscience is which genes regulate brain circuits that underlie cognitive functions. However, the field is still in its infancy. Here we report an integrated investigation of the ... -
Gene Expression Data from the Moon Jelly, Aurelia, Provide Insights into the Evolution of the Combinatorial Code Controlling Animal Sense Organ Development
(Public Library of Science, 2015-07)In Bilateria, Pax6, Six, Eya and Dach families of transcription factors underlie the development and evolution of morphologically and phyletically distinct eyes, including the compound eyes in Drosophila and the camera-type ... -
Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer
(American Association for Cancer Research (AACR), 2021-01)BACKGROUND: Men engaged in high physical activity have lower risks of advanced and fatal prostate cancer. Mechanisms underlying this association are not well understood but may include systemic and tumor-specific effects. ... -
Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer
(American Association for Cancer Research (AACR), 2021-01)BACKGROUND: Men engaged in high physical activity have lower risks of advanced and fatal prostate cancer. Mechanisms underlying this association are not well understood but may include systemic and tumor-specific effects. ... -
Gene Expression Patterns during Light and Dark Infection of Prochlorococcus by Cyanophage
(Public Library of Science, 2016-10)Cyanophage infecting the marine cyanobacteria Prochlorococcus and Synechococcus require light and host photosystem activity for optimal reproduction. Many cyanophages encode multiple photosynthetic electron transport (PET) ... -
Gene expression prediction using low-rank matrix completion
(BioMed Central, 2016-06)Background An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and RNA-Seq. Most data generated using such methods are ... -
A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers
(BioMed Central Ltd, 2012-08)Abstract Background Understanding the fundamental mechanisms of tumorigenesis remains one of the most pressing problems in modern biology. To this end, stem-like cells with tumor-initiating potential have become a central ... -
Gene expression profiles and transcriptional regulatory pathways underlying mouse tissue macrophage identity and diversity
(Nature Publishing Group, 2012-09)We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively ... -
Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer
(Wiley, 2017-07)BACKGROUND: Obese men are at higher risk of advanced prostate cancer and cancer-specific mortality; however, the biology underlying this association remains unclear. This study examined gene expression profiles of prostate ... -
Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries
(Biomed Central Ltd., 2013-11)Background: Pseudo-nitzschia multiseries Hasle (Hasle) (Ps-n) is distinctive among the ecologically important marine diatoms because it produces the neurotoxin domoic acid. Although the biology of Ps-n has been investigated ... -
Gene networks that compensate for crosstalk with crosstalk
(Springer Science and Business Media LLC, 2019-09-06)Crosstalk is a major challenge to engineering sophisticated synthetic gene networks. A common approach is to insulate signal-transduction pathways by minimizing molecular-level crosstalk between endogenous and synthetic ... -
Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence
(Public Library of Science, 2014-12)Reproductive senescence is a hallmark of aging. The molecular mechanisms regulating reproductive senescence and its association with the aging of somatic cells remain poorly understood. From a full genome RNA interference ... -
A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary
(Public Library of Science, 2015-09)The chromosomal program of meiotic prophase, comprising events such as laying down of meiotic cohesins, synapsis between homologs, and homologous recombination, must be preceded and enabled by the regulated induction of ... -
Gene Transfer into the Lung by Nanoparticle Dextran-Spermine/Plasmid DNA Complexes
(Hindawi Publishing Corporation, 2010)A novel cationic polymer, dextran-spermine (D-SPM), has been found to mediate gene expression in a wide variety of cell lines and in vivo through systemic delivery. Here, we extended the observations by determining the ... -
Gene- and genome-based analysis of significant codon patterns in yeast, rat and mice genomes with the CUT Codon UTilization tool
(Elsevier BV, 2016-05)The translation of mRNA in all forms of life uses a three-nucleotide codon and aminoacyl-tRNAs to synthesize a protein. There are 64 possible codons in the genetic code, with codons for the ∼20 amino acids and 3 stop codons ...
