Now showing items 213-232 of 35800

    • Ab initio study of the low-temperature phases of lithium imide 

      Mueller, Timothy K.; Ceder, Gerbrand (American Physical Society, 2010-11)
      We present a low-temperature structural model for lithium imide (Li[subscript 2]NH) that is consistent with experimental studies. Using the cluster expansion formalism and density-functional theory, we have identified a ...
    • ABC triblock bottlebrush copolymer-based injectable hydrogels: design, synthesis, and application to expanding the therapeutic index of cancer immunochemotherapy 

      Vohidov, Farrukh; Milling, Lauren Elizabeth; Chen, Qixian; Zhang, Wenxu; Bhagchandani, Sachin Haresh; e.a. (Royal Society of Chemistry (RSC), 2020-06)
      Bottlebrush copolymers are a versatile class of macromolecular architectures with broad applications in the fields of drug delivery, self-assembly, and polymer networks. Here, the modular nature of graft-through ring-opening ...
    • Abelian F-theory models with charge-3 and charge-4 matter 

      Raghuram, Nikhil (Springer Berlin Heidelberg, 2018-05)
      This paper analyzes U(1) F-theory models admitting matter with charges q = 3 and 4. First, we systematically derive a q = 3 construction that generalizes the previous q = 3 examples. We argue that U(1) symmetries can be ...
    • Abelian varieties isogenous to a power of an elliptic curve 

      Jordan, Bruce W.; Keeton, Allan G.; Poonen, Bjorn; Rains, Eric M.; Shepherd-Barron, Nicholas; e.a. (Wiley, 2018-03)
      Let be an elliptic curve over a field k. Let [mathematical notation] . There is a functor [mathematical notation] from the category of finitely presented torsion-free left R-modules to the category of abelian varieties ...
    • Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML 

      Lindblad, O; Cordero, E; Puissant, A; Macaulay, L; Kabir, N N; e.a. (Nature Publishing Group, 2016-02)
      Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of FLT3 inhibitor resistance, ...
    • Aberrant AKT activation drives well-differentiated liposarcoma 

      Gutierrez, Alejandro; Snyder, Eric; Marino-Enriquez, Adrian; Zhang, Yi-Xiang; Sioletic, Stefano; e.a. (Proceedings of the National Academy of Sciences (PNAS), 2011-09)
      Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded ...
    • Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency 

      Sasaki, Tomoyuki; Lian, Shanshan; Qi, Jie; Bayliss, Peter E.; Carr, Christopher E.; e.a. (Public Library of Science, 2014-06)
      Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H[superscript +]-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces ...
    • Aberrant Development and Plasticity of Excitatory Visual Cortical Networks in the Absence of cpg15 

      Picard, Nathalie; Leslie, Jennifer H.; Trowbridge, Sara Kishi; Subramanian, Jaichandar; Nedivi, Elly; e.a. (Society for Neuroscience, 2014-03)
      During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the ...
    • Aberrant Glycosylation Promotes Lung Cancer Metastasis through Adhesion to Galectins in the Metastatic Niche 

      Reticker-Flynn, Nathan E.; Bhatia, Sangeeta N. (American Association for Cancer Research, 2014-11)
      Metastasis is the leading cause of cancer-associated deaths. Although dissemination of tumor cells likely occurs early in tumorigenesis, the constituents of the microenvironment play essential rate-limiting roles in ...
    • Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease 

      Sathasivam, Kirupa; Neueder, Andreas; Gipson, Theresa Anne; Landles, Christian; Benjamin, Agnesska C.; e.a. (National Academy of Sciences (U.S.), 2013-01)
      Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
    • Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease 

      Gipson, Theresa Anne; Housman, David E.; Sathasivam, Kirupa; Neueder, Andreas; Landles, Christian; e.a. (National Academy of Sciences (U.S.), 2013-01)
      Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
    • Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase 

      Greenblatt, Wesley H.; Rubenstein, Eric M.; Kreft, Stefan G.; Swanson, Robert; Hochstrasser, Mark (Rockefeller University Press, The, 2012-06)
      Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the ...
    • Aberration corrected emittance exchange 

      Nanni, Emilio Alessandro; Graves, William S. (American Physical Society, 2015-08)
      Full exploitation of emittance exchange (EEX) requires aberration-free performance of a complex imaging system including active radio-frequency (rf) elements which can add temporal distortions. We investigate the performance ...
    • Abiotic Gene Transfer: Rare or Rampant? 

      Kotnik, Tadej; Weaver, James C (Springer US, 2016-04)
      Phylogenetic studies reveal that horizontal gene transfer (HGT) plays a prominent role in evolution and genetic variability of life. Five biotic mechanisms of HGT among prokaryotic organisms have been extensively characterized: ...
    • Abl Kinase Inhibits the Engulfment of Apoptotic [corrected] Cells in Caenorhabditis elegans 

      Hurwitz, Michael Eliezer; Vanderzalm, Pamela J.; Bloom, Laird; Goldman, Julia; Garriga, Gian; e.a. (Public Library of Science, 2009-04)
      The engulfment of apoptotic cells is required for normal metazoan development and tissue remodeling. In Caenorhabditis elegans, two parallel and partially redundant conserved pathways act in cell-corpse engulfment. One ...
    • Abl suppresses cell extrusion and intercalation during epithelium folding 

      Jodoin, Jeanne; Martin, Adam C (American Society for Cell Biology, 2016-07)
      Tissue morphogenesis requires control over cell shape changes and rearrangements. In the Drosophila mesoderm, linked epithelial cells apically constrict, without cell extrusion or intercalation, to fold the epithelium into ...
    • Able to Do the Impossible 

      Spencer II, John Haven (Oxford University Press (OUP), 2016-09)
      According to a widely held principle—the poss-ability principle—an agent, S, is able to Φ only if it is metaphysically possible for S to Φ. I argue against the poss-abilityprinciple by developing a novel class of ...
    • Abnormal structural and functional brain connectivity in gray matter heterotopia 

      Christodoulou, Joanna; Walker, Linsey M.; Del Tufo, Stephanie N.; Katzir, Tami; Gabrieli, John D. E.; e.a. (John Wiley & Sons, Inc, 2012-06)
      Purpose:  Periventricular nodular heterotopia (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain malformations ...
    • Abnormal Synaptic Vesicle Biogenesis in Drosophila Synaptogyrin Mutants 

      Stevens, Robin Jean; Akbergenova, Yulia; Jorquera, Ramon; Littleton, J. Troy (Society for Neuroscience, 2012-12)
      Sustained neuronal communication relies on the coordinated activity of multiple proteins that regulate synaptic vesicle biogenesis and cycling within the presynaptic terminal. Synaptogyrin and synaptophysin are conserved ...
    • Abortion and Selection 

      Gruber, Jonathan; Ananat, Elizabeth Oltmans; Staiger, Douglas; Levine, Phillip B. (MIT Press, 2009-01)
      Abortion legalization in the early 1970s led to dramatic changes in fertility. Some research has suggested that it altered cohort outcomes, but this literature has been limited and controversial. In this paper, we provide ...