Now showing items 7651-7670 of 34872

    • DNA Damage and Its Links to Neurodegeneration 

      Madabhushi, Ram; Pan, Ling; Tsai, Li-Huei (Elsevier/Cell Press, 2014-07)
      The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with ...
    • A DNA damage checkpoint in Caulobacter crescentus inhibits cell division through a direct interaction with FtsW 

      Modell, Joshua W.; Hopkins, Alexander C.; Laub, Michael T. (Cold Spring Harbor Laboratory, 2011-05)
      Following DNA damage, cells typically delay cell cycle progression and inhibit cell division until their chromosomes have been repaired. The bacterial checkpoint systems responsible for these DNA damage responses are ...
    • A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus 

      Modell, Joshua W.; Kambara, Tracy K.; Laub, Michael T.; Perchuk, Barrett (Public Library of Science, 2014-10)
      Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the ...
    • DNA Damage-Mediated Induction of a Chemoresistant Niche 

      Gilbert, Luke Andrew; Hemann, Michael (Elsevier B.V., 2010-10)
      While numerous cell-intrinsic processes are known to play decisive roles in chemotherapeutic response, relatively little is known about the impact of the tumor microenvironment on therapeutic outcome. Here, we use a ...
    • DNA demethylation by DNA repair 

      Gehring, Mary; Reik, Wolf; Henikoff, Steven (Elsevier Science Publishers, 2009-02)
      Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant ...
    • DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin 

      Zhou, Wen; Riddell, Imogen A.; Yilmaz, Omer H.; Lippard, Stephen J. (American Chemical Society (ACS), 2019-01-02)
      Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex. To understand the underlying molecular mechanism, we ...
    • DNA methylation and imprinting in plants: machinery and mechanisms 

      Satyaki, P. R. V.; Gehring, Mary (Informa UK (Informa Healthcare), 2017-01)
      Imprinting is an epigenetic phenomenon in which genes are expressed selectively from either the maternal or paternal alleles. In plants, imprinted gene expression is found in a tissue called the endosperm. Imprinting is ...
    • DNA methylation dynamics of the human preimplantation embryo 

      Smith, Zachary D.; Chan, Michelle Mei Wah; Humm, Kathryn C.; Karnik, Rahul; Mekhoubad, Shila; e.a. (Nature Publishing Group, 2014-07)
      In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distributed across the genome, with local, cell-type-specific regulation directed by DNA binding factors. This comparatively ...
    • DNA Methylation Heterogeneity Patterns in Breast Cancer Cell Lines 

      Sun, Shuying; Bertelsmann, Karina; Yu, Linda; Sun, Shuying; Tian, Sunny (Libertas Academica, Ltd., 2016-09)
      Heterogeneous DNA methylation patterns are linked to tumor growth. In order to study DNA methylation heterogeneity patterns for breast cancer cell lines, we comparatively study four metrics: variance, I² statistic, entropy, ...
    • DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis 

      Shell, Scarlet S.; Baek, Seung-Hun; Shah, Rupal R.; Sassetti, Christopher M.; Dedon, Peter C.; e.a. (Public Library of Science, 2013-07)
      DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely ...
    • DNA nanogel encapsulated by a lipid vesicle 

      Kim, A Ra; Moon, James J.; Irvine, Darrell J.; Sunghwan Jung, Darrell J.; Um, Soong Ho (Institute of Electrical and Electronics Engineers (IEEE), 2010-08)
      DNA has been used as a new generic material due to its selectivity and intrinsic biocompatibility, to construct a variety of nano-architectures such as cubic, tetrahedral, and even complicated origami. Recently, a 3-D ...
    • DNA Nanotechnology: A foundation for Programmable Nanoscale Materials 

      Bathe, Mark; Rothemund, Paul W.K. (Cambridge University Press (Materials Research Society), 2017-12)
      DNA nanotechnology is a materials design paradigm in which synthetic nucleic acids are used to program the structure and dynamics of nanometer-scale devices and materials. Driven by the convergence of decreasing DNA synthesis ...
    • DNA nanotechnology: new adventures for an old warhorse 

      Zakeri, Bijan; Lu, Timothy K (Elsevier, 2015-06)
      As the blueprint of life, the natural exploits of DNA are admirable. However, DNA should not only be viewed within a biological context. It is an elegantly simple yet functionally complex chemical polymer with properties ...
    • DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics 

      Dupradeau, François-Yves; Case, David A.; Chen, Jingyang; Turner, Christopher John; Stubbe, JoAnne (Oxford University Press (OUP), 2007-11)
      Abasic sites are common DNA lesions resulting from spontaneous depurination and excision of damaged nucleobases by DNA repair enzymes. However, the influence of the local sequence context on the structure of the abasic ...
    • DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria 

      Wang, Lianrong; Jiang, Susu; Deng, Zixin; Dedon, Peter C; Chen, Shi (Oxford University Press (OUP), 2018-10)
      Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is replaced by a sulphur atom, share similar physical and chemical properties with phosphodiesters but confer enhanced nuclease tolerance ...
    • DNA phosphorothioation is widespread and quantized in bacterial genomes 

      Wang, Lianrong; Chen, Shi; Vergin, Kevin L.; Giovannoni, Stephen J.; Chan, Simon W.; e.a. (National Academy of Sciences, 2011-02)
      Phosphorothioate (PT) modification of DNA, with sulfur replacing a nonbridging phosphate oxygen, was recently discovered as a product of the dnd genes found in bacteria and archaea. Given our limited understanding of the ...
    • DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts 

      Braithwaite, Elena K.; Kedar, Padmini S.; Stumpo, Deborah J.; Bertocci, Barbara; Freedman, Jonathan H.; e.a. (Public Library of Science, 2010-08)
      Base excision repair (BER) is a DNA repair pathway designed to correct small base lesions in genomic DNA. While DNA polymerase beta (pol β) is known to be the main polymerase in the BER pathway, various studies have ...
    • DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme 

      Kitange, Gaspar J.; Gupta, Shiv K.; Sarkaria, Jann N.; Nagel, Zachary D.; Joughin, Brian Alan; e.a. (American Association for Cancer Research (AACR), 2016-10)
      Cancer cells can resist the effects of DNA-damaging therapeutic agents via utilization of DNA repair pathways, suggesting that DNA repair capacity (DRC) measurements in cancer cells could be used to identify patients most ...
    • DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro 

      Bian, Ke; Lenz, Stefan A P; Tang, Qi; Chen, Fangyi; Qi, Rui; e.a. (Oxford University Press (OUP), 2019-05)
      5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ...
    • DNA repair is indispensable for survival after acute inflammation 

      Calvo, Jennifer A.; Meira, Lisiane B.; Lee, Chun-Yue I.; Moroski-Erkul, Catherine A.; Abolhassani, Nona; e.a. (American Society for Clinical Investigation, 2012-06)
      More than 15% of cancer deaths worldwide are associated with underlying infections or inflammatory conditions, therefore understanding how inflammation contributes to cancer etiology is important for both cancer prevention ...