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Browsing MIT Open Access Articles by Title

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  • Trigo Neri Tabuada, Goncalo Jorge (Mathematical Sciences Publishers, 2016-09)
    C. Weibel, and Thomason and Trobaugh, proved (under some assumptions) that algebraic K-theory with coefficients is A1-homotopy invariant. We generalize this result from schemes to the broad setting of dg categories. Along ...
  • Trigo Neri Tabuada, Goncalo Jorge (European Mathematical Publishing House, 2017-12)
    In this note we prove some structural properties of all the A1-homotopy invariants of corner skew Laurent polynomial algebras. As an application, we compute the mod-l algebraic K-theory of Leavitt path algebras using solely ...
  • Trigo Neri Tabuada, Goncalo Jorge (Elsevier, 2015-04)
    Let A be a dg category, F : A →A be a dg functor inducing an equivalence of categories in degree-zero cohomology, and A /F be the associated dg orbit category. For every A¹-homotopy invariant E ( e.g. homotopy K -theory, ...
  • Baker, Tania; Sauer, Robert T.; Abdelhakim, Aliaa H. (National Academy of Sciences (U.S.), 2009-09)
    A hyperstable complex of the tetrameric MuA transposase with recombined DNA must be remodeled to allow subsequent DNA replication. ClpX, a AAA+ enzyme, fulfills this function by unfolding one transpososome subunit. Which ...
  • Calvo, Jennifer A.; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey Wood; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick T.; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013-04)
    Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...
  • Daneshmand, Ali; Mazumder, Aprotim; Allocca, Mariacarmela; Calvo, Jennifer A.; Abolhassani, Nona; Jhun, Iny; Muthupalani, Sureshkumar; Ayata, Cenk; Samson, Leona D.; Ebrahimkhani, Mohammad Reza (National Academy of Sciences (U.S.), 2014-10)
    Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial ...
  • Chow, Ryan D; Guzman, Christopher D; Wang, Guangchuan; Schmidt, Florian; Youngblood, Mark W; Ye, Lupeng; Errami, Youssef; Dong, Matthew B; Martinez, Michael A; Zhang, Sensen; Renauer, Paul; Bilguvar, Kaya; Gunel, Murat; Platt, Randall J; Chen, Sidi; Sharp, Phillip A; Zhang, Feng (Nature Publishing Group, 2017-08)
    A causative understanding of genetic factors that regulate glioblastoma pathogenesis is of central importance. Here we developed an adeno-associated virus-mediated, autochthonous genetic CRISPR screen in glioblastoma. ...
  • Raghuram, Nikhil (Springer Berlin Heidelberg, 2018-05)
    This paper analyzes U(1) F-theory models admitting matter with charges q = 3 and 4. First, we systematically derive a q = 3 construction that generalizes the previous q = 3 examples. We argue that U(1) symmetries can be ...
  • Lindblad, O; Cordero, E; Puissant, A; Macaulay, L; Kabir, N N; Sun, J; Vallon-Christersson, J; Haraldsson, K; Borg, Å; Levander, F; Stegmaier, K; Pietras, K; Rönnstrand, L; Kazi, J U; Ramos, A.; Hemann, Michael (Nature Publishing Group, 2016-02)
    Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of FLT3 inhibitor resistance, ...
  • Gutierrez, Alejandro; Snyder, Eric; Marino-Enriquez, Adrian; Zhang, Yi-Xiang; Sioletic, Stefano; Kozakewich, Elena; Grebliunaite, Ruta; Ou, Wen-bin; Sicinska, Ewa; Raut, Chandrajit P.; Demetri, George D.; Perez-Atayde, Antonio R.; Wagner, Andrew J.; Fletcher, Jonathan A.; Fletcher, Christopher D. M.; Look, A. Thomas (Proceedings of the National Academy of Sciences (PNAS), 2011-09)
    Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded ...
  • Sasaki, Tomoyuki; Lian, Shanshan; Qi, Jie; Bayliss, Peter E.; Carr, Christopher E.; Johnson, Jennifer L.; Guha, Sujay; Kobler, Patrick; Catz, Sergio D.; Gill, Matthew; Jia, Kailiang; Klionsky, Daniel J.; Kishi, Shuji (Public Library of Science, 2014-06)
    Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H[superscript +]-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces ...
  • Picard, Nathalie; Leslie, Jennifer H.; Trowbridge, Sara Kishi; Subramanian, Jaichandar; Nedivi, Elly; Fagiolini, Michela (Society for Neuroscience, 2014-03)
    During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the ...
  • Reticker-Flynn, Nathan E.; Bhatia, Sangeeta N. (American Association for Cancer Research, 2014-11)
    Metastasis is the leading cause of cancer-associated deaths. Although dissemination of tumor cells likely occurs early in tumorigenesis, the constituents of the microenvironment play essential rate-limiting roles in ...
  • Gipson, Theresa Anne; Housman, David E.; Sathasivam, Kirupa; Neueder, Andreas; Landles, Christian; Benjamin, Agnesska C.; Bondulich, Marie K.; Smith, Donna L.; Faull, Richard L. M.; Roos, Raymund A. C.; Howland, David; Detloff, Peter J.; bates, Gillian P. (National Academy of Sciences (U.S.), 2013-01)
    Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
  • Sathasivam, Kirupa; Neueder, Andreas; Gipson, Theresa Anne; Landles, Christian; Benjamin, Agnesska C.; Bondulich, Marie K.; Amith, Donna L.; Faull, Richard L. M.; Roos, Raymund A. C.; Howland, David; Detloff, Peter J.; Housman, David E.; Bates, Gillian P. (National Academy of Sciences (U.S.), 2013-01)
    Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
  • Greenblatt, Wesley H.; Rubenstein, Eric M.; Kreft, Stefan G.; Swanson, Robert; Hochstrasser, Mark (Rockefeller University Press, The, 2012-06)
    Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the ...
  • Nanni, Emilio Alessandro; Graves, William S. (American Physical Society, 2015-08)
    Full exploitation of emittance exchange (EEX) requires aberration-free performance of a complex imaging system including active radio-frequency (rf) elements which can add temporal distortions. We investigate the performance ...
  • Beane, Silas R.; Chang, Emmanuel; Detmold, William; Orginos, Kostas; Savage, Martin J.; Tiburzi, Brian C.; Parreno, Assumpta (American Physical Society, 2015-09)
    Lattice QCD calculations of two-nucleon systems are used to isolate the short-distance two-body electromagnetic contributions to the radiative capture process np → dγ, and the photo-disintegration processes γ[superscript ...
  • Ceresoli, Davide; Marzari, Nicola; Lopez, M. G.; Thonhauser, T. (American Physical Society, 2010-05)
    We extend the recently developed converse NMR approach [Thonhauser et al., J. Chem. Phys. 131, 101101 (2009)] such that it can be used in conjunction with norm-conserving, nonlocal pseudopotentials. This extension permits ...
  • Lee, Yueh-Lin; Morgan, Dane (American Physical Society, 2015-05)
    In this paper, we perform a comparative study based on ab initio modeling for perovskite ABO[subscript 3] (001) surfaces and surface defect energetics in order to understand the influence of polarity and redox active Mn ...
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