Now showing items 24992-25011 of 32098

    • S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration 

      Bhat, Vadiraja B.; Seneviratnea, Uthpala; Nott, Alexi; Ravindra, Kodihalli C.; Wishnok, John S; e.a. (National Academy of Sciences (U.S.), 2016-03)
      Protein S-nitrosation (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an important regulatory mechanism of protein function in both physiological and pathological pathways. A ...
    • S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration 

      Bhat, Vadiraja B.; Seneviratne, Uthpala Indrajith; Nott, Alexander; Kodihalli, Ravindra; Wishnok, John S; e.a. (National Academy of Sciences (U.S.), 2016-04)
      Protein S-nitrosation (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an important regulatory mechanism of protein function in both physiological and pathological pathways. A ...
    • S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models 

      Oh, Chang-Ki; Sultan, Abdullah; Platzer, Joseph; Dolatabadi, Nima; Soldner, Frank; e.a. (Elsevier, 2017-11)
      Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson's disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. ...
    • S-Store: a streaming NewSQL system for big velocity applications 

      Cetintemel, Ugur; Tufte, Kristin; Wang, Hao; Zdonik, Stanley; Du, Jiang; e.a. (Association for Computing Machinery (ACM), 2014-08)
      First-generation streaming systems did not pay much attention to state management via ACID transactions (e.g., [3, 4]). S-Store is a data management system that combines OLTP transactions with stream processing. To create ...
    • S-Store: streaming meets transaction processing 

      Meehan, John; Pavlo, Andrew; Tufte, Kristin; Zdonik, Stan; Aslantas, Cansu; e.a. (Association for Computing Machinery, 2015-09)
      Stream processing addresses the needs of real-time applications. Transaction processing addresses the coordination and safety of short atomic computations. Heretofore, these two modes of operation existed in separate, ...
    • S[subscript n]-equivariant sheaves and Koszul cohomology 

      Yang, David H. (Springer, 2014-11)
      Purpose: We give a new interpretation of Koszul cohomology, which is equivalent under the Bridgeland-King-Reid equivalence to Voisin's Hilbert scheme interpretation in dimensions 1 and 2 but is different in higher ...
    • Sacred Cars? Cost-Effective Regulation of Stationary and Nonstationary Pollution Sources 

      Fowlie, Meredith; Knittel, Christopher Roland; Wolfram, Catherine (American Economic Association, 2012-02)
      For political and practical reasons, environmental regulations sometimes treat point-source polluters, such as power plants, differently from mobile-source polluters, such as vehicles. This paper measures the extent of ...
    • Sacrificial-Post Templating Method for Block Copolymer Self-Assembly 

      Alexander-Katz, Alfredo; Ross, Caroline A.; Berggren, Karl K.; Tavakkoli Kermani Ghariehali, Amir; Nicaise, Sam; e.a. (Wiley Blackwell, 2013-07)
      A sacrificial-post templating method is presented for directing block copolymer self-assembly to form nanostructures consisting of monolayers and bilayers of microdomains. In this approach, the topographical post template ...
    • Saddle Point in the Minimax Converse for Channel Coding 

      Polyanskiy, Yury (Institute of Electrical and Electronics Engineers, 2013-05)
      A minimax metaconverse has recently been proposed as a simultaneous generalization of a number of classical results and a tool for the nonasymptotic analysis. In this paper, it is shown that the order of optimizing the ...
    • Saddle point localization of molecular wavefunctions 

      Mellau, Georg Ch.; Kyuberis, Alexandra A.; Polyansky, Oleg L.; Zobov, Nikolai; Field, Robert W (Nature Publishing Group, 2016-09)
      The quantum mechanical description of isomerization is based on bound eigenstates of the molecular potential energy surface. For the near-minimum regions there is a textbook-based relationship between the potential and ...
    • Safe and Efficient Tetrazole Synthesis in a Continuous Flow Microreactor 

      Palde, Prakash B.; Jamison, Timothy F. (Wiley Blackwell, 2011-03)
      Safer flow: The synthesis of 5-substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near-equimolar amount of NaN[subscript 3], yet nonetheless displays a broad ...
    • Safe Asset Scarcity and Aggregate Demand 

      Farhi, Emmanuel; Gourinchas, Pierre-Olivier; Caballero, Ricardo J (American Economic Association, 2016-05)
      We explore the consequences of safe asset scarcity on aggregate demand in a stylized IS-LM/Mundell Fleming style environment. Acute safe asset scarcity forces the economy into a "safety trap" recession. In the open economy, ...
    • The Safe Assets Shortage Conundrum 

      Farhi, Emmanuel; Gourinchas, Pierre-Olivier; Caballero, Ricardo J (American Economic Association, 2017-08)
      A safe asset is a simple debt instrument that is expected to preserve its value during adverse systemic events. The supply of safe assets, private and public, has historically been concentrated in a small number of advanced ...
    • Safe Fall: Humanoid robot fall direction change through intelligent stepping and inertia shaping 

      Yun, Seung-kook; Goswami, Ambarish; Sakagami, Yoshiaki (Institute of Electrical and Electronics Engineers (IEEE), 2009-08)
      Although fall is a rare event in the life of a humanoid robot, we must be prepared for it because its consequences are serious. In this paper we present a fall strategy which rapidly modifies the robot's fall direction in ...
    • Safe Local Navigation for Visually Impaired Users with a Time-of-Flight and Haptic Feedback Device 

      Katzschmann, Robert Kevin; Araki, Brandon; Rus, Daniela L (Institute of Electrical and Electronics Engineers (IEEE), 2018-03)
      This paper presents ALVU (Array of Lidars and Vibrotactile Units), a contactless, intuitive, hands-free, and discreet wearable device that allows visually impaired users to detect low- and high-hanging obstacles, as well ...
    • Safe Local Navigation for Visually Impaired Users With a Time-of-Flight and Haptic Feedback Device 

      Katzschmann, Robert Kevin; Rus, Daniela L; Araki, Minoru B (Institute of Electrical and Electronics Engineers (IEEE), 2018-01)
      This paper presents ALVU (Array of Lidars and Vibrotactile Units), a contactless, intuitive, hands-free, and discreet wearable device that allows visually impaired users to detect low- and high-hanging obstacles, as well ...
    • Safe Visual Navigation via Deep Learning and Novelty Detection 

      Richter, Charles Andrew; Roy, Nicholas (Robotics: Science and Systems Foundation, 2017-07)
      Robots that use learned perceptual models in the real world must be able to safely handle cases where they are forced to make decisions in scenarios that are unlike any of their training examples. However, state-of-the-art ...
    • Safely active mobility for urban baby boomers: The role of neighborhood design 

      Lee, Jae Seung; Zegras, Pericles C; Ben-Joseph, Eran (Elsevier, 2013-12)
      Many urban designers and researchers argue that walkable urban environments can encourage older residents’ walking activities that benefit their physical health. However, walking also exposes older adults to safety risks, ...
    • Safety Analysis of a 300-MW(electric) Offshore Floating Nuclear Power Plant in Marine Environment 

      Zhang, Yaoli; Buongiorno, Jacopo; Golay, Michael W; Todreas, Neil E (American Nuclear Society, 2018-03)
      The Offshore Floating Nuclear Plant (OFNP) integrates an advanced light water reactor into a cylindrical, double-hull, floating platform. It offers a series of potential benefits in economics and safety. The 300-MW(electric) ...
    • Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER) 

      Cho, Eun-Ae; Cai, Hong; Au-Yeung, Annie; China, Carlos; Yosufi, Benafsha; e.a. (Elsevier, 2013-05)
      Background The nuclear transcription factor c-Jun is preferentially expressed in basal-cell carcinoma. Dz13 is a deoxyribozyme that targets JUN messenger RNA and has inhibited the growth of a range of tumours in mice. We ...