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Browsing MIT Open Access Articles by Author "Tsai, Li-Huei"

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Browsing MIT Open Access Articles by Author "Tsai, Li-Huei"

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  • Frank, Christopher Lee; Tsai, Li-Huei (Elsevier, 2009-05)
    Recent studies have demonstrated that boundaries separating a cycling cell from a postmitotic neuron are not as concrete as expected. Novel and unique physiological functions in neurons have been ascribed for proteins ...
  • Pimplikar, Sanjay W.; Nixon, Ralph A.; Robakis, Nikolaos K.; Shen, Jie; Tsai, Li-Huei (Society for Neuroscience, 2010-11)
    Despite the progress of the past two decades, the cause of Alzheimer's disease (AD) and effective treatments against it remain elusive. The hypothesis that amyloid-β (Aβ) peptides are the primary causative agents of AD ...
  • Calderon de Anda, Froylan; Rosario, Ana Lucia; Durak, Omer; Tran, Tracy; Meletis, Konstantinos; Rei, Damien; Soda, Takahiro; Madabhushi, Ram; Ginty, David D; Kolodkin, Alex L; Tsai, Li-Huei; Graff, Johannes (Nature Publishing Group, 2012-06)
    How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. ...
  • Rei, Damien; Mason, Xenos; Seo, Jinsoo; Rudenko, Andrii; Wang, Jun; Siegert, Sandra; Cho, Sukhee; Deisseroth, Karl; Tsai, Li-Huei; Graeff, Johannes; Rueda IV, Richard; Canter, Rebecca Gail; Mungenast, Alison (National Academy of Sciences (U.S.), 2015-06)
    Repeated stress has been suggested to underlie learning and memory deficits via the basolateral amygdala (BLA) and the hippocampus; however, the functional contribution of BLA inputs to the hippocampus and their molecular ...
  • Zukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Huei; Lanier, Lorene M.; Gertler, Frank (Elsevier, 2000-06)
    Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a ...
  • Zhang, Lei; Zhu, J. Julius; Clauser, Karl R.; Carr, Steven A.; Guan, Ji-Song; Su, Susan Chih-Chieh; Gao, Jun; Joseph, Nadine; Xie, Zhigang; Zhou, Ying; Durak, Omer; Tsai, Li-Huei (Public Library of Science, 2011-09)
    Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory ...
  • Buchman, Joshua J.; Tseng, Huan-Chung; Zhou, Ying; Frank, Christopher Lee; Xie, Zhigang; Tsai, Li-Huei (Elsevier B.V., 2010-05)
    Primary autosomal-recessive microcephaly (MCPH) and Majewski osteodysplastic primordial dwarfism type II (MOPDII) are both genetic diseases that result in decreased brain size at birth. MCPH is thought to arise from ...
  • Calderon de Anda, Froylan; Meletis, Konstantinos; Ge, Xuecai; Rei, Damien; Tsai, Li-Huei (Society for Neuroscience, 2010-08)
    The mechanisms underlying the normal development of neuronal morphology remain a fundamental question in neurobiology. Studies in cultured neurons have suggested that the position of the centrosome and the Golgi may predict ...
  • Singh, Karun K.; De Rienzo, Gianluca; Drane, Laurel; Mao, Yingwei; Flood, Zachary; Madison, Jon M.; Ferreira, Manuel; Bergen, Sarah; King, Cillian; Sklar, Pamela; Sive, Hazel; Tsai, Li-Huei; Singh, Karun K. (Elsevier, 2011-11)
    Disrupted in Schizophrenia-1 (DISC1) is a candidate gene for psychiatric disorders and has many roles during brain development. Common DISC1 polymorphisms (variants) are associated with neuropsychiatric phenotypes including ...
  • Gjoneska, Elizabeta; Pfenning, Andreas R.; Mathys, Hansruedi; Quon, Gerald; Kundaje, Anshul; Tsai, Li-Huei; Kellis, Manolis (American Association for the Advancement of Science (AAAS), 2015-02)
    Alzheimer’s disease (AD) is a severe age-related neurodegenerative disorder characterized by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes ...
  • Frank, Christopher Lee; Ge, Xuecai; Xie, Zhigang; Zhou, Ying; Tsai, Li-Huei (2010-08)
    Organogenesis is a highly integrated process with a fundamental requirement for precise cell cycle control. Mechanistically, the cell cycle is composed of transitions and thresholds that are controlled by coordinated ...
  • Murn, Jernej; Zarnack, Kathi; Yang, Yawei J.; Durak, Omer; Murphy, Elisabeth A.; Cheloufi, Sihem; Gonzalez, Dilenny M.; Teplova, Marianna; Curk, Tomaž; Zuber, Johannes; Patel, Dinshaw J.; Ule, Jernej; Luscombe, Nicholas M.; Tsai, Li-Huei; Walsh, Christopher A.; Shi, Yang (Cold Spring Harbor Laboratory Press, 2015-03)
    Cellular morphology is an essential determinant of cellular function in all kingdoms of life, yet little is known about how cell shape is controlled. Here we describe a molecular program that controls the early morphology ...
  • Jones, S. R.; Deisseroth, Karl; Carlen, Marie; Meletis, Konstantinos; Siegle, Joshua Handman; Cardin, Jessica A.; Futai, Kensuke; Vierling-Claassen, Dorea L.; Ruhlmann, C.; Sheng, Morgan Hwa-Tze; Moore, Christopher I.; Tsai, Li-Huei (Nature Publishing Group, 2011-04)
    Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates gamma oscillations, rhythms that emerge during performance of cognitive tasks. Administration of N-methyl-D-aspartate (NMDA) receptor ...
  • Ishizuka, K; Park, Y-U; Park, S K; Sawa, A; Soda, Takahiro; Frank, Christopher Lee; Flood, Zachary; Baccarella, A.; Tsai, Li-Huei (Nature Publishing Group, 2013-04)
    Disrupted-In-Schizophrenia 1 (DISC1), a risk factor for major mental illnesses, has been studied extensively in the context of neurodevelopment. However, the role of DISC1 in neuronal signaling, particularly in conjunction ...
  • Mao, Yingwei; Ge, Xuecai; Frank, Christopher Lee; Madison, Jon M.; Koehler, Angela Nicole; Doud, Mary Kathryn; Tassa, Carlos; Berry, Erin M.; Soda, Takahiro; Singh, Karun K.; Biechele, Travis; Petryshen, Tracey L.; Moon, Randall T.; Haggarty, Stephen J.; Tsai, Li-Huei (Elsevier, 2009-03)
    The Disrupted in Schizophrenia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scottish family with a high incidence of major depression, schizophrenia, and bipolar disorder. ...
  • Singh, Karun K.; Ge, Xuecai; Mao, Yingwei; Drane, Laurel; Meletis, Konstantinos; Samuels, Benjamin A.; Tsai, Li-Huei (Elsevier, 2010-07)
    The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is ...
  • Ericsson, M.; Shen, Abra H.; Canter, Rebecca Gail; Tsai, Li-Huei; Bero, Adam W.; Meng, Jia; Cho, Sukhee (National Academy of Sciences (U.S.), 2014-07)
    Understanding the mechanisms by which long-term memories are formed and stored in the brain represents a central aim of neuroscience. Prevailing theory suggests that long-term memory encoding involves early plasticity ...
  • Rei, Damien; Guan, Ji-Song; Wang, Wen-Yuan; Seo, Jinsoo; Hennig, Krista M.; Nieland, Thomas J. F.; Fass, Daniel M.; Kao, Patricia F.; Kahn, Martin; Su, Susan C.; Samiei, Alireza; Joseph, Nadine; Haggarty, Stephen J.; Delalle, Ivana; Tsai, Li-Huei; Graff, Johannes (Nature Publishing Group, 2012-02)
    Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervous system, including Alzheimer’s disease [superscript 1]. The causes leading to such impairment are only poorly understood ...
  • Kim, Jongpil; Su, Susan C.; Wang, Haoyi; Cheng, Albert W.; Cassady, John P.; Lodato, Michael Anthony; Lengner, Christopher J.; Chung, Chee Yeun; Dawlaty, Meelad M.; Tsai, Li-Huei; Jaenisch, Rudolf (Elsevier, 2011-10)
    Recent advances in somatic cell reprogramming have highlighted the plasticity of the somatic epigenome, particularly through demonstrations of direct lineage reprogramming of one somatic cell type to another by defined ...
  • Zhao, Wen-Ning; Cheng, Chialin; Theriault, Kraig M.; Sheridan, Steven D.; Tsai, Li-Huei; Haggarty, Stephen J. (Sage Publications, 2012-08)
    Wnt/β-catenin signaling has emerged as a central player in pathways implicated in the pathophysiology and treatment of neuropsychiatric disorders. To identify potential novel therapeutics for these disorders, high-throughput ...
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