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Comprehensive variation discovery in single human genomes
(Nature Publishing Group, 2014-10)
Complete knowledge of the genetic variation in individual human genomes is a crucial foundation for understanding the etiology of disease. Genetic variation is typically characterized by sequencing individual genomes and ...
DNA methylation and imprinting in plants: machinery and mechanisms
(Informa UK (Informa Healthcare), 2017-01)
Imprinting is an epigenetic phenomenon in which genes are expressed selectively from either the maternal or paternal alleles. In plants, imprinted gene expression is found in a tissue called the endosperm. Imprinting is ...
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
(Elsevier B.V., 2013-05)
Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study the regulatory mechanisms that facilitate cellular transitions in a human context. To that end, we performed comprehensive ...
CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development
(Impact Journals, LLC, 2017-11)
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the oxyntic gland within the gastric corpus. Chief cells at the base of the gastric corpus also express Mist1. The relevance ...
Genome-wide dissection of microRNA functions and cotargeting networks using gene-set signatures
(Elsevier, 2010-04)
MicroRNAs are emerging as important regulators of diverse biological processes and pathologies in animals and plants. Though hundreds of human microRNAs are known, only a few have known functions. Here, we predict human ...
The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies
(Public Library of Science, 2015-11)
Aberrant chromatin regulation is a frequent driver of leukemogenesis. Mutations in chromatin regulators often result in more stem-like cells that seed a bulk leukemic population. Inhibitors targeting these proteins represent ...
Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing
(Springer Nature, 2017-03)
The opening and closing of two ring-shaped Mcm2-7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear. The origin-recognition complex (ORC), ...
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
(Nature Publishing Group, 2013-02)
Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically miss low-allelic-fraction mutations that occur in only a subset of the sequenced cells owing ...
Dual Roles for PARP1 during Heat Shock: Transcriptional Activator and Posttranscriptional Inhibitor of Gene Expression
(Elsevier, 2013-01)
In this issue of Molecular Cell, Di Giammartino et al. (2012) identify a new function for PARP1 in the post-transcriptional regulation of mRNAs via ADP-ribosylation of poly(A) polymerase, a mRNA 3′ processing enzyme.
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
(Cold Spring Harbor Laboratory Press, 2014-08)
Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative capacity of differentiated cell lineages by restricting the reservoir of telomeric repeats. ...