Search
Now showing items 1-10 of 32060
Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network
(Wiley-VCH Verlag GmbH & Co., 2012-03)
A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large ...
Osteotropic Therapy via Targeted Layer-by-Layer Nanoparticles
(Wiley-VCH Verlag GmbH & Co., 2014-06)
Current treatment options for debilitating bone diseases such as osteosarcoma, osteoporosis, and bone metastatic cancer are suboptimal and have low efficacy. New treatment options for these pathologies require targeted ...
Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity
(American Association for Cancer Research, 2013-02)
Immunostimulatory agonists such as anti-CD137 and interleukin (IL)-2 have elicited potent antitumor immune responses in preclinical studies, but their clinical use is limited by inflammatory toxicities that result upon ...
When Noisy Neighbors Are a Blessing: Analysis of Gene Expression Noise Identifies Coregulated Genes
(Elsevier, 2012-02)
In this issue of Molecular Cell, Stewart-Ornstein et al. (2012) use systematic pair-wise correlation analysis of expression noise in a large number of yeast genes to identify clusters of functionally related genes and ...
Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation
(Elsevier, 2012-11)
Microcephaly is a neurodevelopmental disorder causing significantly reduced cerebral cortex size. Many known microcephaly gene products localize to centrosomes, regulating cell fate and proliferation. Here, we identify and ...
Rational Design of a Biomimetic Cell Penetrating Peptide Library
(American Chemical Society (ACS), 2013-09)
Cell penetrating peptides have demonstrated potential to facilitate the cellular delivery of therapeutic molecules. Here we develop a set of 50 cell penetrating peptide based formulations with potential to deliver small ...
Histone Deacetylase 5 Limits Cocaine Reward through cAMP-Induced Nuclear Import
(Elsevier, 2012-01)
Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient ...
AZFc Deletions and Spermatogenic Failure: A Population-Based Survey of 20,000 Y Chromosomes
(Elsevier, 2012-10)
Deletions involving the Y chromosome’s AZFc region are the most common known genetic cause of severe spermatogenic failure (SSF). Six recurrent interstitial deletions affecting the region have been reported, but their ...
Methanogenic burst in the end-Permian carbon cycle
(National Academy of Sciences (U.S.), 2014-04)
The end-Permian extinction is associated with a mysterious disruption to Earth’s carbon cycle. Here we identify causal mechanisms via three observations. First, we show that geochemical signals indicate superexponential ...
Quantum quenches in the many-body localized phase
(American Physical Society, 2014-11)
Many-body localized (MBL) systems are characterized by the absence of transport and thermalization and, therefore, cannot be described by conventional statistical mechanics. In this paper, using analytic arguments and ...