Now showing items 1-4 of 4
Whsc1 links pluripotency exit with mesendoderm specification
(Springer Science and Business Media LLC, 2019-06)
How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here, we show that the chromatin-related factor Whsc1 (also known as Nsd2 and MMSET) has a dual role in ...
Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma
(Elsevier Science Ltd., 2018-11-16)
Appropriate post-translational processing of collagen requires prolyl hydroxylation, catalyzed by collagen prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase, and is essential for normal cell function. Here we have ...
Identification of cell cycle-targeting microRNAs through genome-wide screens
(Informa UK Limited, 2017-11-14)
By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting ...
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
(Springer Nature, 2018-01-29)
CRISPR-Cas9 is a versatile RNA-guided genome editing tool. Here we demonstrate that partial replacement of RNA nucleotides with DNA nucleotides in CRISPR RNA (crRNA) enables efficient gene editing in human cells. This ...