Search
Now showing items 1-10 of 13
High‐fat diet in a mouse insulin‐resistant model induces widespread rewiring of the phosphotyrosine signaling network
(EMBO, 2019-08)
Obesity-associated type 2 diabetes and accompanying diseases have developed into a leading human health risk across industrialized and developing countries. The complex molecular underpinnings of how lipid overload and ...
Multi-cell ECM compaction is predictable via superposition of nonlinear cell dynamics linearized in augmented state space
(Public Library of Science (PLoS), 2019-09-20)
Cells interacting through an extracellular matrix (ECM) exhibit emergent behaviors resulting from collective intercellular interaction. In wound healing and tissue development, characteristic compaction of ECM gel is induced ...
Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices
(Public Library of Science (PLoS), 2019-04-08)
The mechanical properties of the extracellular matrix (ECM)–a complex, 3D, fibrillar scaffold of cells in physiological environments–modulate cell behavior and can drive tissue morphogenesis, regeneration, and disease ...
Combinatorial prediction of marker panels from single‐cell transcriptomic data
(EMBO, 2019-10)
Single-cell transcriptomic studies are identifying novel cell populations with exciting functional roles in various in vivo contexts, but identification of succinct gene marker panels for such populations remains a challenge. ...
A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation
(Public Library of Science (PLoS), 2019-04-22)
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Energetics of optimal undulatory swimming organisms
(Public Library of Science (PLoS), 2019-10-31)
Energy consumption is one of the primary considerations in animal locomotion. In swimming locomotion, a number of questions related to swimming energetics of an organism and how the energetic quantities scale with body ...
DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images
(Public Library of Science (PLoS), 2019-05-13)
Neuronal synapses transmit electrochemical signals between cells through the coordinated action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors. In situ structural characterization ...
Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation
(Public Library of Science (PLoS), 2019-05-02)
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of ...
Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT)
(Public Library of Science (PLoS), 2018-10-26)
Substrate permissiveness has long been regarded as the raw materials for the evolution of new enzymatic functions. In land plants, hydroxycinnamoyltransferase (HCT) is an essential enzyme of the phenylpropanoid metabolism. ...
Multi-modality in gene regulatory networks with slow promoter kinetics
(Public Library of Science (PLoS), 2019-02-19)
Phenotypical variability in the absence of genetic variation often reflects complex energetic landscapes associated with underlying gene regulatory networks (GRNs). In this view, different phenotypes are associated with ...