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Accurate Multiobjective Design in a Space of Millions of Transition Metal Complexes with Neural-Network-Driven Efficient Global Optimization
(American Chemical Society (ACS), 2020-03-11)
© 2020 American Chemical Society. The accelerated discovery of materials for real world applications requires the achievement of multiple design objectives. The multidimensional nature of the search necessitates exploration ...
Voltage-gated optics and plasmonics enabled by solid-state proton pumping
(Springer Science and Business Media LLC, 2019-11-06)
Devices with locally-addressable and dynamically tunable optical properties underpin emerging technologies such as high-resolution reflective displays and dynamic holography. The optical properties of metals such as Y and ...
Climate change exacerbates hurricane flood hazards along US Atlantic and Gulf Coasts in spatially varying patterns
(Springer Science and Business Media LLC, 2019-08-22)
One of the most destructive natural hazards, tropical cyclone (TC)–induced coastal flooding, will worsen under climate change. Here we conduct climatology–hydrodynamic modeling to quantify the effects of sea level rise ...
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
(Springer Science and Business Media LLC, 2019-10-21)
The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)-block-pol ...
Gene networks that compensate for crosstalk with crosstalk
(Springer Science and Business Media LLC, 2019-09-06)
Crosstalk is a major challenge to engineering sophisticated synthetic gene networks. A common approach is to insulate signal-transduction pathways by minimizing molecular-level crosstalk between endogenous and synthetic ...
Percolation thresholds for photonic quantum computing
(Springer Science and Business Media LLC, 2019-03-06)
Despite linear-optical fusion (Bell measurement) being probabilistic, photonic cluster states for universal quantum computation can be prepared without feed-forward by fusing small n-photon entangled clusters, if the success ...
Towards integrated tunable all-silicon free-electron light sources
(Springer Science and Business Media LLC, 2019-07-18)
Extracting light from silicon is a longstanding challenge in modern engineering and physics. While silicon has underpinned the past 70 years of electronics advancement, a facile tunable and efficient silicon-based light ...
Nuclei multiplexing with barcoded antibodies for single-nucleus genomics
(Springer Science and Business Media LLC, 2019-07-02)
Single-nucleus RNA-seq (snRNA-seq) enables the interrogation of cellular states in complex tissues that are challenging to dissociate or are frozen, and opens the way to human genetics studies, clinical trials, and precise ...
Catalytic, contra-Thermodynamic Positional Alkene Isomerization
(American Chemical Society (ACS), 2021-12)
The positional isomerization of C═C double bonds is a powerful strategy for the interconversion of alkene regioisomers. However, existing methods provide access to thermodynamically more stable isomers from less stable ...
Methods for estimating supersaturation in antisolvent crystallization systems
(Royal Society of Chemistry (RSC), 2019-08)
The mole fraction and activity coefficient-dependent (MFAD) supersaturation expression is the least-assumptive, practical choice for calculating supersaturation in solvent mixtures. This paper reviews the basic thermodynamic ...