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Ultrafast Graphene Light Emitters
(American Chemical Society, 2018-01-22)
Ultrafast electrically driven nanoscale light sources are critical components in nanophotonics. Compound semiconductor-based light sources for the nanophotonic platforms have been extensively investigated over the past ...
Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides
(Wiley, 2018-02)
Exon-skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon-skipping activity requires that these macromolecules reach the nucleus. While cell-penetrating peptides can improve delivery, ...
All-Optical Quantum Sensing of Rotational Brownian Motion of Magnetic Molecules
(American Chemical Society (ACS), 2019-09-24)
Sensing the local environment through the motional response of small molecules lays the foundation of many fundamental technologies. The information on local viscosity, for example, is contained in the random rotational ...
Designing yeast as plant-like hyperaccumulators for heavy metals
(Springer Science and Business Media LLC, 2019-11-08)
Hyperaccumulators typically refer to plants that absorb and tolerate elevated amounts of heavy metals. Due to their unique metal trafficking abilities, hyperaccumulators are promising candidates for bioremediation applications. ...
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
(Springer Science and Business Media LLC, 2019-12)
A heritable polymorphism within regulatory sequences of the LMO1 gene is associated with its elevated expression and increased susceptibility to develop neuroblastoma, but the oncogenic pathways downstream of the LMO1 ...
Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
(Springer Science and Business Media LLC, 2019-07-19)
Diosgenin is a spiroketal steroidal natural product extracted from plants and used as the single most important precursor for the world steroid hormone industry. The sporadic occurrences of diosgenin in distantly related ...
Complex DNA knots detected with a nanopore sensor
(Springer Science and Business Media LLC, 2019-10-02)
Equilibrium knots are common in biological polymers—their prevalence, size distribution, structure, and dynamics have been extensively studied, with implications to fundamental biological processes and DNA sequencing ...
Mortality causes universal changes in microbial community composition
(Springer Science and Business Media LLC, 2019-05-09)
All organisms are sensitive to the abiotic environment, and a deteriorating environment can cause extinction. However, survival in a multispecies community depends upon interactions, and some species may even be favored ...
DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin
(American Chemical Society (ACS), 2019-01-02)
Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex. To understand the underlying molecular mechanism, we ...
Discovery of TaFeSb-based half-Heuslers with high thermoelectric performance
(Springer Science and Business Media LLC, 2019-01-17)
Discovery of thermoelectric materials has long been realized by the Edisonian trial and error approach. However, recent progress in theoretical calculations, including the ability to predict structures of unknown phases ...