Search
Now showing items 1-10 of 21
Can machine learning improve patient selection for cardiac resynchronization therapy?
(Public Library of Science (PLoS), 2019-10-03)
Rationale Multiple clinical trials support the effectiveness of cardiac resynchronization therapy (CRT); however, optimal patient selection remains challenging due to substantial treatment heterogeneity among patients who ...
TGF-β signaling in cellular senescence and aging-related pathology
(MDPI AG, 2019-10-10)
Aging is broadly defined as the functional decline that occurs in all body systems. The accumulation of senescent cells is considered a hallmark of aging and thought to contribute to the aging pathologies. Transforming ...
Using Machine Learning and Natural Language Processing to Review and Classify the Medical Literature on Cancer Susceptibility Genes
(American Society of Clinical Oncology (ASCO), 2019-12)
© 2019 by American Society of Clinical Oncology PURPOSE The medical literature relevant to germline genetics is growing exponentially. Clinicians need tools that help to monitor and prioritize the literature to understand ...
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia
(Springer Science and Business Media LLC, 2019-02-25)
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous loss-of-function point mutations of miRNA genes are associated with several human congenital disorders 1–5 , but neomorphic ...
If the Coast Guard is the Solution, What is the Problem?
(Wiley, 2021-01)
Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
(eLife Sciences Publications, Ltd., 2018-11-09)
Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness ...
Aerodigestive sampling reveals altered microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function
(Public Library of Science (PLoS), 2019-05-20)
Background Children with oropharyngeal dysphagia have impaired airway protection mechanisms and are at higher risk for pneumonia and other pulmonary complications. Aspiration of gastric contents is often implicated as a ...
Comprehensive analysis of chromosomal mobile genetic elements in the gut microbiome reveals phylum-level niche-adaptive gene pools
(Public Library of Science (PLoS), 2019-12-12)
Mobile genetic elements (MGEs) drive extensive horizontal transfer in the gut microbiome. This transfer could benefit human health by conferring new metabolic capabilities to commensal microbes, or it could threaten human ...
Spatial optimization for radiation therapy of brain tumours
(Public Library of Science (PLoS), 2019-06-28)
Glioblastomas are the most common primary brain tumours. They are known for their highly aggressive growth and invasion, leading to short survival times. Treatments for glioblastomas commonly involve a combination of ...
Fracture in drug‐eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery
(Wiley, 2018-09-23)
Objectives: Drug-eluting stent (DES) strut fracture (SF) is associated with higher incidence of In-stent restenosis (ISR)—return of blockage in a diseased artery post stenting—than seen with bare metal stents (BMS). We ...