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Pièce de Self-Résistance: a New Paradigm for Natural-Product Herbicide Discovery
(Elsevier BV, 2018-09)
Modern agriculture is faced with the challenge of feeding a rapidly growing population.While crop yields have risen dramatically since the beginning of the twentieth century, increasing demand for foodthreatens to outstrip ...
A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation
(Public Library of Science (PLoS), 2019-04-22)
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
(Springer Science+Business Media, 2019-07-30)
Background: Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets for complex diseases, but is complicated by the involvement of thousands of variably expressed genes across ...
Multi-modality in gene regulatory networks with slow promoter kinetics
(Public Library of Science (PLoS), 2019-02-19)
Phenotypical variability in the absence of genetic variation often reflects complex energetic landscapes associated with underlying gene regulatory networks (GRNs). In this view, different phenotypes are associated with ...
Data-driven computational protein design
(Elsevier BV, 2021-08)
Computational protein design can generate proteins not found in nature that adopt desired structures and perform novel functions. Although proteins could, in theory, be designed with ab initio methods, practical success ...
Structural and Functional Analysis of E. coli Cyclopropane Fatty Acid Synthase
(Elsevier BV, 2018-09)
Cell membranes must adapt to different environments. In Gram-negative bacteria, the inner membrane can be remodeled directly by modification of lipids embedded in the bilayer. For example, when Escherichia coli enters ...
Identification of cell cycle-targeting microRNAs through genome-wide screens
(Informa UK Limited, 2017-11-14)
By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting ...
Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation
(Public Library of Science (PLoS), 2019-05-02)
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of ...
DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images
(Public Library of Science (PLoS), 2019-05-13)
Neuronal synapses transmit electrochemical signals between cells through the coordinated action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors. In situ structural characterization ...
Energetics of optimal undulatory swimming organisms
(Public Library of Science (PLoS), 2019-10-31)
Energy consumption is one of the primary considerations in animal locomotion. In swimming locomotion, a number of questions related to swimming energetics of an organism and how the energetic quantities scale with body ...