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Histidine catabolism is a major determinant of methotrexate sensitivity
(Springer Science and Business Media LLC, 2018-07)
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by ...
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
(American Association for the Advancement of Science (AAAS), 2018-04-26)
The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease.We performed quantitative proteomic ...