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Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications
(Elsevier BV, 2019-02)
Characterization data of fluorescent nanoparticles made of cellulose acetate (CA-dots) are shown. The data in this article accompanies the research article “Ultrabright fluorescent cellulose acetate nanoparticles for imaging ...
Regularizations of time-crystal dynamics
(Proceedings of the National Academy of Sciences, 2019-08-14)
We demonstrate that nonconvex Lagrangians, as contemplated in the theory of time crystals, can arise in the effective description of conventional, physically realizable systems. Such embeddings resolve dynamical singularities ...
CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer
(Proceedings of the National Academy of Sciences, 2019-12)
Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer that remains among the most lethal of solid tumor malignancies. Recent genomic sequencing studies have identified many recurrently mutated genes ...
Biohybrid valveless pump-bot powered by engineered skeletal muscle
(Proceedings of the National Academy of Sciences, 2019-01-11)
Pumps are critical life-sustaining components for all animals. At the earliest stages of life, the tubular embryonic heart works as a valveless pump capable of generating unidirectional blood flow. Inspired by this elementary ...
Comprehensive comparison of pore-scale models for multiphase flow in porous media
(Proceedings of the National Academy of Sciences, 2019-06-21)
Multiphase flows in porous media are important in many natural and industrial processes. Pore-scale models for multiphase flows have seen rapid development in recent years and are becoming increasingly useful as predictive ...
Helical nanofiber yarn enabling highly stretchable engineered microtissue
(Proceedings of the National Academy of Sciences, 2019-04-24)
Development of microtissues that possess mechanical properties mimicking those of native stretchable tissues, such as muscle and tendon, is in high demand for tissue engineering and regenerative medicine. However, regardless ...
Predicting neighborhoods’ socioeconomic attributes using restaurant data
(Proceedings of the National Academy of Sciences, 2019-07-15)
Accessing high-resolution, timely socioeconomic data such as data on population, employment, and enterprise activity at the neighborhood level is critical for social scientists and policy makers to design and implement ...
Development of an autonomous and bifunctional quorum-sensing circuit for metabolic flux control in engineered Escherichia coli
(Proceedings of the National Academy of Sciences, 2019-12-03)
Metabolic engineering seeks to reprogram microbial cells to efficiently and sustainably produce value-added compounds. Since chemical production can be at odds with the cell’s natural objectives, strategies have been ...
Using massive online choice experiments to measure changes in well-being
(Proceedings of the National Academy of Sciences, 2019-03-26)
Gross domestic product (GDP) and derived metrics such as productivity have been central to our understanding of economic progress and well-being. In principle, changes in consumer surplus provide a superior, and more direct, ...
OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks
(Springer Science and Business Media LLC, 2019-08-28)
Organoid cultures are proving to be powerful in vitro models that closely mimic the cellular constituents of their native tissue. Organoids are typically expanded and cultured in a 3D environment using either naturally ...