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Spatial optimization for radiation therapy of brain tumours
(Public Library of Science (PLoS), 2019-06-28)
Glioblastomas are the most common primary brain tumours. They are known for their highly aggressive growth and invasion, leading to short survival times. Treatments for glioblastomas commonly involve a combination of ...
High‐fat diet in a mouse insulin‐resistant model induces widespread rewiring of the phosphotyrosine signaling network
(EMBO, 2019-08)
Obesity-associated type 2 diabetes and accompanying diseases have developed into a leading human health risk across industrialized and developing countries. The complex molecular underpinnings of how lipid overload and ...
Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
(Public Library of Science (PLoS), 2019-11-07)
The common marmoset (Callithrix jacchus) is increasingly used as an animal model for biomedical research; however, gastrointestinal diseases causing significant morbidity are endemic in many captive marmoset colonies. ...
Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
(Public Library of Science (PLoS), 2019-09-20)
The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the ...
The Univariate Flagging Algorithm (UFA): An interpretable approach for predictive modeling
(Public Library of Science (PLoS), 2019-10-11)
In many data classification problems, a number of methods will give similar accuracy. However, when working with people who are not experts in data science such as doctors, lawyers, and judges among others, finding ...
Combinatorial prediction of marker panels from single‐cell transcriptomic data
(EMBO, 2019-10)
Single-cell transcriptomic studies are identifying novel cell populations with exciting functional roles in various in vivo contexts, but identification of succinct gene marker panels for such populations remains a challenge. ...
Can machine learning improve patient selection for cardiac resynchronization therapy?
(Public Library of Science (PLoS), 2019-10-03)
Rationale Multiple clinical trials support the effectiveness of cardiac resynchronization therapy (CRT); however, optimal patient selection remains challenging due to substantial treatment heterogeneity among patients who ...
Framework for rational donor selection in fecal microbiota transplant clinical trials
(Public Library of Science (PLoS), 2019-10-10)
Early clinical successes are driving enthusiasm for fecal microbiota transplantation (FMT), the transfer of healthy gut bacteria through whole stool, as emerging research is linking the microbiome to many different diseases. ...
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites
(Public Library of Science (PLoS), 2019-02-06)
Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp. parasites that cause malaria contain an essential, non-photosynthetic plastid—the apicoplast— which originated from a secondary ...
Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1
(Public Library of Science (PLoS), 2019-06-10)
Bcl-2 family proteins control a decisive apoptotic event: mitochondrial outer membrane permeabilization (MOMP). To discover MOMP-regulating proteins, we expressed a library of intracellular single-chain variable fragments ...