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C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly
Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X-interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 ...
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
(eLife Sciences Publications, Ltd, 2018-05-10)
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the ...