Now showing items 1-4 of 4
Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
(eLife Sciences Publications, Ltd., 2018-11-09)
Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness ...
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
(Elsevier BV, 2018-12)
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ...
Next-Generation Machine Learning for Biological Networks
(Elsevier BV, 2018-06)
Machine learning, a collection of data-analytical techniques aimed at building predictive models from multi-dimensional datasets, is becoming integral to modern biological research. By enablingone to generate models that ...
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
(eLife Sciences Publications, Ltd, 2018-05-10)
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the ...