Now showing items 1-4 of 4
Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
(eLife Sciences Publications, Ltd., 2018-11-09)
Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness ...
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
(eLife Sciences Publications, Ltd, 2018-05-10)
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the ...
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites
(Public Library of Science (PLoS), 2019-02-06)
Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp. parasites that cause malaria contain an essential, non-photosynthetic plastid—the apicoplast— which originated from a secondary ...
Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1
(Public Library of Science (PLoS), 2019-06-10)
Bcl-2 family proteins control a decisive apoptotic event: mitochondrial outer membrane permeabilization (MOMP). To discover MOMP-regulating proteins, we expressed a library of intracellular single-chain variable fragments ...