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Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT)
(Public Library of Science (PLoS), 2018-10-26)
Substrate permissiveness has long been regarded as the raw materials for the evolution of new enzymatic functions. In land plants, hydroxycinnamoyltransferase (HCT) is an essential enzyme of the phenylpropanoid metabolism. ...
A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation
(Public Library of Science (PLoS), 2019-04-22)
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation
(Public Library of Science (PLoS), 2019-05-02)
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of ...
Energetics of optimal undulatory swimming organisms
(Public Library of Science (PLoS), 2019-10-31)
Energy consumption is one of the primary considerations in animal locomotion. In swimming locomotion, a number of questions related to swimming energetics of an organism and how the energetic quantities scale with body ...
Brain-wide connectome inferences using functional connectivity MultiVariate Pattern Analyses (fc-MVPA)
(Public Library of Science (PLoS), 2022-11-15)
<jats:p>Current functional Magnetic Resonance Imaging technology is able to resolve billions of individual functional connections characterizing the human connectome. Classical statistical inferential procedures attempting ...
Multi-cell ECM compaction is predictable via superposition of nonlinear cell dynamics linearized in augmented state space
(Public Library of Science (PLoS), 2019-09-20)
Cells interacting through an extracellular matrix (ECM) exhibit emergent behaviors resulting from collective intercellular interaction. In wound healing and tissue development, characteristic compaction of ECM gel is induced ...
Multi-modality in gene regulatory networks with slow promoter kinetics
(Public Library of Science (PLoS), 2019-02-19)
Phenotypical variability in the absence of genetic variation often reflects complex energetic landscapes associated with underlying gene regulatory networks (GRNs). In this view, different phenotypes are associated with ...
DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images
(Public Library of Science (PLoS), 2019-05-13)
Neuronal synapses transmit electrochemical signals between cells through the coordinated action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors. In situ structural characterization ...
Probabilistic program inference in network-based epidemiological simulations
(Public Library of Science (PLoS), 2022-11-07)
<jats:p>Accurate epidemiological models require parameter estimates that account for mobility patterns and social network structure. We demonstrate the effectiveness of probabilistic programming for parameter inference in ...
Mechanisms controlling the trafficking, localization, and abundance of presynaptic Ca2+ channels
(Frontiers Media SA, 2023-01-13)
<jats:p>Voltage-gated Ca<jats:sup>2+</jats:sup> channels (VGCCs) mediate Ca<jats:sup>2+</jats:sup> influx to trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of ...