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NUFIP1 is a ribosome receptor for starvation-induced ribophagy 

Wyant, Gregory A.; Abu-Remaileh, Monther; Frenkel, Evgeni M.; Laqtom, Nouf N.; Dharamdasani, Vimisha; e.a. (American Association for the Advancement of Science (AAAS), 2018-04-26)
The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease.We performed quantitative proteomic ...
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Histidine catabolism is a major determinant of methotrexate sensitivity 

Kanarek, Naama; Keys, Heather R.; Cantor, Jason R.; Lewis, Caroline A.; Chan, Sze Ham; e.a. (Springer Science and Business Media LLC, 2018-07)
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by ...

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AuthorAbu-Remaileh, Monther (2)Chan, Sze Ham (2)
Lewis, Caroline A. (2)
Sabatini, David M. (2)Cantor, Jason R. (1)Dharamdasani, Vimisha (1)Freinkman, Elizaveta (1)Frenkel, Evgeni M. (1)Kanarek, Naama (1)Keys, Heather R. (1)... View MoreSubject
Multidisciplinary (2)
... View MoreDate Issued2018 (2)Has File(s)Yes (2)

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