Now showing items 1-5 of 5
Histidine catabolism is a major determinant of methotrexate sensitivity
(Springer Science and Business Media LLC, 2018-07)
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by ...
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
(American Association for the Advancement of Science (AAAS), 2018-04-26)
The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease.We performed quantitative proteomic ...
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
(National Academy of Sciences, 2019-04)
Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural ...
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
(Springer Science and Business Media LLC, 2019-02-13)
Cholesterol is essential for cells to grow and proliferate. Normal mammalian cells meet their need for cholesterol through its uptake or de novo synthesis1, but the extent to which cancer cells rely on each of these pathways ...
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program
(Proceedings of the National Academy of Sciences, 2019-05-09)
During skeletal muscle regeneration, muscle stem cells (MuSCs) respond to multiple signaling inputs that converge onto mammalian target of rapamycin complex 1 (mTORC1) signaling pathways. mTOR function is essential for ...