Now showing items 1-2 of 2
Histidine catabolism is a major determinant of methotrexate sensitivity
(Springer Science and Business Media LLC, 2018-07)
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by ...
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
(National Academy of Sciences, 2019-04)
Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural ...