Now showing items 1-2 of 2
Histidine catabolism is a major determinant of methotrexate sensitivity
(Springer Science and Business Media LLC, 2018-07)
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by ...
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
(Springer Science and Business Media LLC, 2019-02-13)
Cholesterol is essential for cells to grow and proliferate. Normal mammalian cells meet their need for cholesterol through its uptake or de novo synthesis1, but the extent to which cancer cells rely on each of these pathways ...