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Gene-guided discovery and engineering of branched cyclic peptides in plants
(Proceedings of the National Academy of Sciences, 2018-10-29)
The plant kingdom contains vastly untapped natural product chemistry, which has been traditionally explored through the activity-guided approach. Here, we describe a gene-guided approach to discover and engineer a class ...
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
(American Association for the Advancement of Science (AAAS), 2018-04-26)
The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease.We performed quantitative proteomic ...
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
(Springer Science and Business Media LLC, 2018-11-28)
Mutations that attenuate homologous recombination (HR)-mediated repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as ‘BRCAness’1. BRCAness tumours ...
Predictions of novel Schistosoma mansoni-human protein interactions consistent with experimental data
(Springer Science and Business Media LLC, 2018-08-30)
Infection by the human blood fluke, Schistosoma mansoni involves a variety of cross-species protein- protein interactions. The pathogen expresses a diverse arsenal of proteins that facilitate the breach of physical and ...
Altered exocrine function can drive adipose wasting in early pancreatic cancer
(Springer Science and Business Media LLC, 2018-06)
Changes in cell and organismal metabolism accompany malignancy1,2. Pancreatic ductal adenocarcinoma (PDAC) is associated with peripheral tissue wasting, a metabolic syndrome that lowers quality of life and is proposed to ...
Histidine catabolism is a major determinant of methotrexate sensitivity
(Springer Science and Business Media LLC, 2018-07)
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by ...
Secondary magnetite in ancient zircon precludes analysis of a Hadean geodynamo
(Proceedings of the National Academy of Sciences, 2018-12-31)
Zircon crystals from the Jack Hills, Western Australia, are one of the few surviving mineralogical records of Earth’s first 500 million years and have been proposed to contain a paleomagnetic record of the Hadean geodynamo. ...