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Histidine catabolism is a major determinant of methotrexate sensitivity
(Springer Science and Business Media LLC, 2018-07)
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by ...
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
(American Association for the Advancement of Science (AAAS), 2018-04-26)
The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease.We performed quantitative proteomic ...
Gene-guided discovery and engineering of branched cyclic peptides in plants
(Proceedings of the National Academy of Sciences, 2018-10-29)
The plant kingdom contains vastly untapped natural product chemistry, which has been traditionally explored through the activity-guided approach. Here, we describe a gene-guided approach to discover and engineer a class ...
Secondary magnetite in ancient zircon precludes analysis of a Hadean geodynamo
(Proceedings of the National Academy of Sciences, 2018-12-31)
Zircon crystals from the Jack Hills, Western Australia, are one of the few surviving mineralogical records of Earth’s first 500 million years and have been proposed to contain a paleomagnetic record of the Hadean geodynamo. ...
Predictions of novel Schistosoma mansoni-human protein interactions consistent with experimental data
(Springer Science and Business Media LLC, 2018-08-30)
Infection by the human blood fluke, Schistosoma mansoni involves a variety of cross-species protein- protein interactions. The pathogen expresses a diverse arsenal of proteins that facilitate the breach of physical and ...
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
(Springer Science and Business Media LLC, 2018-11-28)
Mutations that attenuate homologous recombination (HR)-mediated repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as ‘BRCAness’1. BRCAness tumours ...
Altered exocrine function can drive adipose wasting in early pancreatic cancer
(Springer Science and Business Media LLC, 2018-06)
Changes in cell and organismal metabolism accompany malignancy1,2. Pancreatic ductal adenocarcinoma (PDAC) is associated with peripheral tissue wasting, a metabolic syndrome that lowers quality of life and is proposed to ...