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OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks
(Springer Science and Business Media LLC, 2019-08-28)
Organoid cultures are proving to be powerful in vitro models that closely mimic the cellular constituents of their native tissue. Organoids are typically expanded and cultured in a 3D environment using either naturally ...
Top-down fabrication of high-uniformity nanodiamonds by self-assembled block copolymer masks
(Springer Science and Business Media LLC, 2019-05-06)
Nanodiamonds hosting colour centres are a promising material platform for various quantum technologies. The fabrication of non-aggregated and uniformly-sized nanodiamonds with systematic integration of single quantum ...
Massively multiplexed nucleic acid detection using Cas13
(Springer Science and Business Media LLC, 2020-04)
The overwhelming majority of globally circulating pathogens go undetected, undermining patient care and hindering outbreak preparedness and response. To enable routine surveillance and comprehensive diagnostic applications, ...
Universal amplification-free molecular diagnostics by billion-fold hierarchical nanofluidic concentration
(Proceedings of the National Academy of Sciences, 2019-07-29)
Rapid and reliable detection of ultralow-abundance nucleic acids and proteins in complex biological media may greatly advance clinical diagnostics and biotechnology development. Currently, nucleic acid tests rely on enzymatic ...
A relatively wide-bandgap and air-stable donor polymer for fabrication of efficient semitransparent and tandem organic photovoltaics
(Proceedings of the National Academy of Sciences, 2019-10-16)
Organic photovoltaics (OPVs) have attracted tremendous attention in the field of thin-film solar cells due to their wide range of applications, especially for semitransparent devices. Here, we synthesize a dithiaindaceno ...
Choosing Clinical Variables for Risk Stratification Post-Acute Coronary Syndrome
(Springer Science and Business Media LLC, 2019-10-10)
Most risk stratification methods use expert opinion to identify a fixed number of clinical variables that have prognostic significance. In this study our goal was to develop improved metrics that utilize a variable number ...