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Combinatorial prediction of marker panels from single‐cell transcriptomic data
(EMBO, 2019-10)
Single-cell transcriptomic studies are identifying novel cell populations with exciting functional roles in various in vivo contexts, but identification of succinct gene marker panels for such populations remains a challenge. ...
High‐fat diet in a mouse insulin‐resistant model induces widespread rewiring of the phosphotyrosine signaling network
(EMBO, 2019-08)
Obesity-associated type 2 diabetes and accompanying diseases have developed into a leading human health risk across industrialized and developing countries. The complex molecular underpinnings of how lipid overload and ...
Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease
(Springer Science and Business Media LLC, 2024-03-11)
Microbial biochemistry is central to the pathophysiology of inflammatory bowel diseases (IBD). Improved knowledge of microbial metabolites and their immunomodulatory roles is thus necessary for diagnosis and management. ...