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Catalytic, contra-Thermodynamic Positional Alkene Isomerization
(American Chemical Society (ACS), 2021-12)
The positional isomerization of C═C double bonds is a powerful strategy for the interconversion of alkene regioisomers. However, existing methods provide access to thermodynamically more stable isomers from less stable ...
DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin
(American Chemical Society (ACS), 2019-01-02)
Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex. To understand the underlying molecular mechanism, we ...
Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C–N and C–C Bond Formation
(American Chemical Society (ACS), 2019-07-25)
A method for the annulation of amines and carboxylic acids to form pharmaceutically relevant azaheterocycles via organophosphorus PIII/PV redox catalysis is reported. The method employs a phosphetane catalyst together with ...
Enantioselective Allylation Using Allene, a Petroleum Cracking Byproduct
(American Chemical Society (ACS), 2019-01-27)
Allene (C₃H₄) gas is produced and separated on million-metric-ton scale per year during petroleum refining but is rarely employed in organic synthesis. Meanwhile, the addition of an allyl group (C₃H₅) to ketones is among ...