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Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
(eLife Sciences Publications, Ltd., 2018-11-09)
Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness ...
C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly
(Wiley, 2019-07-28)
Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X-interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 ...
Designing yeast as plant-like hyperaccumulators for heavy metals
(Springer Science and Business Media LLC, 2019-11-08)
Hyperaccumulators typically refer to plants that absorb and tolerate elevated amounts of heavy metals. Due to their unique metal trafficking abilities, hyperaccumulators are promising candidates for bioremediation applications. ...
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
(Springer Science and Business Media LLC, 2019-12)
A heritable polymorphism within regulatory sequences of the LMO1 gene is associated with its elevated expression and increased susceptibility to develop neuroblastoma, but the oncogenic pathways downstream of the LMO1 ...
Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
(Springer Science and Business Media LLC, 2019-07-19)
Diosgenin is a spiroketal steroidal natural product extracted from plants and used as the single most important precursor for the world steroid hormone industry. The sporadic occurrences of diosgenin in distantly related ...
Complex DNA knots detected with a nanopore sensor
(Springer Science and Business Media LLC, 2019-10-02)
Equilibrium knots are common in biological polymers—their prevalence, size distribution, structure, and dynamics have been extensively studied, with implications to fundamental biological processes and DNA sequencing ...
Mortality causes universal changes in microbial community composition
(Springer Science and Business Media LLC, 2019-05-09)
All organisms are sensitive to the abiotic environment, and a deteriorating environment can cause extinction. However, survival in a multispecies community depends upon interactions, and some species may even be favored ...
Discovery of TaFeSb-based half-Heuslers with high thermoelectric performance
(Springer Science and Business Media LLC, 2019-01-17)
Discovery of thermoelectric materials has long been realized by the Edisonian trial and error approach. However, recent progress in theoretical calculations, including the ability to predict structures of unknown phases ...
High‐fat diet in a mouse insulin‐resistant model induces widespread rewiring of the phosphotyrosine signaling network
(EMBO, 2019-08)
Obesity-associated type 2 diabetes and accompanying diseases have developed into a leading human health risk across industrialized and developing countries. The complex molecular underpinnings of how lipid overload and ...
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
(Elsevier BV, 2018-12)
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ...