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Now showing items 11-20 of 36
Data-driven computational protein design
(Elsevier BV, 2021-08)
Computational protein design can generate proteins not found in nature that adopt desired structures and perform novel functions. Although proteins could, in theory, be designed with ab initio methods, practical success ...
Transcription factors interact with RNA to regulate genes
(Elsevier BV, 2023-07-03)
BaM-seq and TBaM-seq, highly multiplexed and targeted RNA-seq protocols for rapid, low-cost library generation from bacterial samples
(Oxford University Press (OUP), 2023-01-10)
<jats:title>Abstract</jats:title>
<jats:p>The ability to profile transcriptomes and characterize global gene expression changes has been greatly enabled by the development of RNA sequencing technologies ...
Brain-wide connectome inferences using functional connectivity MultiVariate Pattern Analyses (fc-MVPA)
(Public Library of Science (PLoS), 2022-11-15)
<jats:p>Current functional Magnetic Resonance Imaging technology is able to resolve billions of individual functional connections characterizing the human connectome. Classical statistical inferential procedures attempting ...
Pièce de Self-Résistance: a New Paradigm for Natural-Product Herbicide Discovery
(Elsevier BV, 2018-09)
Modern agriculture is faced with the challenge of feeding a rapidly growing population.While crop yields have risen dramatically since the beginning of the twentieth century, increasing demand for foodthreatens to outstrip ...
Multi-cell ECM compaction is predictable via superposition of nonlinear cell dynamics linearized in augmented state space
(Public Library of Science (PLoS), 2019-09-20)
Cells interacting through an extracellular matrix (ECM) exhibit emergent behaviors resulting from collective intercellular interaction. In wound healing and tissue development, characteristic compaction of ECM gel is induced ...
Multi-modality in gene regulatory networks with slow promoter kinetics
(Public Library of Science (PLoS), 2019-02-19)
Phenotypical variability in the absence of genetic variation often reflects complex energetic landscapes associated with underlying gene regulatory networks (GRNs). In this view, different phenotypes are associated with ...
DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images
(Public Library of Science (PLoS), 2019-05-13)
Neuronal synapses transmit electrochemical signals between cells through the coordinated action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors. In situ structural characterization ...
Structural and Functional Analysis of E. coli Cyclopropane Fatty Acid Synthase
(Elsevier BV, 2018-09)
Cell membranes must adapt to different environments. In Gram-negative bacteria, the inner membrane can be remodeled directly by modification of lipids embedded in the bilayer. For example, when Escherichia coli enters ...
Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study
(Elsevier BV, 2018-11)
In a multicellular organism, somatic mutations represent a permanent record of the past chemical and biochemical perturbations experienced by a cell in its local microenvironment. Akin to a perpetual recording device, with ...