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Deep elastic strain engineering of bandgap through machine learning
(Proceedings of the National Academy of Sciences, 2019-02-15)
Nanoscale specimens of semiconductor materials as diverse as silicon and diamond are now known to be deformable to large elastic strains without inelastic relaxation. These discoveries harbinger a new age of deep elastic ...
Toward electrochemical synthesis of cement—An electrolyzer-based process for decarbonating CaCO₃ while producing useful gas streams
(Proceedings of the National Academy of Sciences, 2019-09-16)
Cement production is currently the largest single industrial emitter of CO₂, accounting for∼8% (2.8 Gtons/y) of global CO₂ emissions.Deep decarbonization of cement manufacturing will require remediation of both the CO₂ ...
A relatively wide-bandgap and air-stable donor polymer for fabrication of efficient semitransparent and tandem organic photovoltaics
(Proceedings of the National Academy of Sciences, 2019-10-16)
Organic photovoltaics (OPVs) have attracted tremendous attention in the field of thin-film solar cells due to their wide range of applications, especially for semitransparent devices. Here, we synthesize a dithiaindaceno ...
Topology on a new facet of bismuth
(Proceedings of the National Academy of Sciences, 2019-06-13)
Bismuth-based materials have been instrumental in the development of topological physics, even though bulk bismuth itself has been long thought to be topologically trivial. A recent study has, however, shown that bismuth ...
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
(National Academy of Sciences, 2019-04)
Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural ...
An ingestible self-orienting system for oral delivery of macromolecules
(American Association for the Advancement of Science (AAAS), 2019-02-07)
Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral ...
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
(Springer Science and Business Media LLC, 2019-08)
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically ...
Choosing Clinical Variables for Risk Stratification Post-Acute Coronary Syndrome
(Springer Science and Business Media LLC, 2019-10-10)
Most risk stratification methods use expert opinion to identify a fixed number of clinical variables that have prognostic significance. In this study our goal was to develop improved metrics that utilize a variable number ...