Now showing items 1-2 of 2
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia
(Springer Science and Business Media LLC, 2019-02-25)
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous loss-of-function point mutations of miRNA genes are associated with several human congenital disorders 1–5 , but neomorphic ...
TGF-β signaling in cellular senescence and aging-related pathology
(MDPI AG, 2019-10-10)
Aging is broadly defined as the functional decline that occurs in all body systems. The accumulation of senescent cells is considered a hallmark of aging and thought to contribute to the aging pathologies. Transforming ...